Browse our Phospholipase C gamma 2 Proteins (PLCG2)

Full name:
Phospholipase C gamma 2 Proteins (PLCG2)
On are 4 Phospholipase C gamma 2 (PLCG2) Proteins from 3 different suppliers available. Additionally we are shipping Phospholipase C gamma 2 Antibodies (275) and Phospholipase C gamma 2 Kits (22) and many more products for this protein. A total of 320 Phospholipase C gamma 2 products are currently listed.
APLAID, FCAS3, Plcg-2, PLCgamma2
list all proteins Gene Name GeneID UniProt
PLCG2 234779 Q8CIH5
Rat PLCG2 PLCG2 29337 P24135
PLCG2 5336 P16885

Show all synonyms

Phospholipase C gamma 2 Proteins (PLCG2) by Origin

Select your origin of interest

More Proteins for Phospholipase C gamma 2 Interaction Partners

Mouse (Murine) Phospholipase C gamma 2 (PLCG2) interaction partners

  1. Results show that mice with the mutated Plcg2 gene were less prone to transformation into MALT lymphomas as a result of elevated Treg numbers, and decrease of pro-inflammatory cytokines.

  2. PLCgamma2 in clear cells plays an essential role in luminal expansion of the epididymis during the prepubertal period in mice

  3. platelet activation through GPVI (show GP6 Proteins) and alphaIIbbeta3 utilizes PLCgamma2 because PLCgamma1 (show PLCG1 Proteins) levels are insufficient to support responsiveness, but that PLCgamma1 (show PLCG1 Proteins) can restore responsiveness if expressed at levels normally achieved by PLCgamma2.

  4. amarogentin prevents platelet activation through the inhibition of PLC (show HSPG2 Proteins) gamma2-PKC cascade and MAPK (show MAPK1 Proteins) pathway

  5. PLCgamma2 and protein kinase C are important upstream signals that regulate myelopoiesis through cytokines.

  6. inflammatory osteolysis can be abrogated by treatment with a molecule composed of the tandem SH2 domains of PLCgamma2.

  7. down-regulation of PLCgamma2-beta-catenin (show CTNNB1 Proteins) pathway occurs in mice and humans and leads to myeloid-derived suppressor cells-mediated tumor expansion.

  8. a novel role of the PLCgamma2-IP(3)-Ca(2 (show CA2 Proteins)+) cascade in the LPS (show TLR4 Proteins)-induced innate immune response pathway where release of intracellular Ca(2 (show CA2 Proteins)+) mediates TLR4 (show TLR4 Proteins) trafficking and subsequent activation of IRF3 (show IRF3 Proteins).

  9. VapB (show VAPB Proteins) positively regulates RANKL (show TNFSF11 Proteins)-mediated osteoclastogenesis via PLCgamma2-Ca(2 (show CA2 Proteins)+)-NFAT (show NFATC1 Proteins) signaling

  10. PLCgamma2 deficiency impairs Dectin-2 (show CLEC6A Proteins)-induced NF-kappaB (show NFKB1 Proteins) and MAPK (show MAPK1 Proteins) activation in response to fungal infection

Human Phospholipase C gamma 2 (PLCG2) interaction partners

  1. R665W and L845F be referred to as allomorphic rather than hypermorphic mutations of PLCG2 Rerouting of the transmembrane signals emanating from BCR (show BCR Proteins) and converging on PLCgamma2 through Rac (show AKT1 Proteins) in ibrutinib-resistant CLL cells may provide novel drug treatment strategies to overcome ibrutinib resistance mediated by PLCG2 mutations or to prevent its development in ibrutinib-treated CLL patients.

  2. Data show that phospholipase Cgamma2 (PLCgamma2) is strongly expressed in B cell non-Hodgkin lymphoma and especially in a large subset of Diffuse large B-cell lymphoma (DLBCL).

  3. Characterization of the effect of missense point-mutation at R665W in PLCG2 on signaling mechanisms of ibrutinib resistance in chronic lymphocytic leukemia cells.

  4. amarogentin prevents platelet activation through the inhibition of PLC (show HSPG2 Proteins) gamma2-PKC (show PRRT2 Proteins) cascade and MAPK (show MAPK1 Proteins) pathway

  5. PLCG2 missense mutation is a risk factor in the development of steroid sensitive nephrotic syndrome in childhood.

  6. The autoinhibitory C-terminal SH2 domain of phospholipase C (show PLC Proteins)-gamma2 stabilizes B cell receptor signalosome assembly.

  7. The relationship between upstream tyrosine kinase (show TXK Proteins) SYK (show SYK Proteins) and its target, PLCgamma2, is maximally predictive and sufficient to distinguish chronic lymphocytic leukemia from healthy controls.

  8. Single-nucleotide polymorphisms in PLCG2 gene is associated with breast cancer risk after menopausal hormone replacement therapy.

  9. identified three distinct mutations in PLCgamma2 in two patients resistant to ibrutinib

  10. early Ca(2 (show CA2 Proteins)+) fluxing provides feed-forward signal amplification by promoting anchoring of the PLCgamma2 C2 domain to phospho-SLP65 (show BLNK Proteins).

Phospholipase C gamma 2 (PLCG2) Protein Profile

Protein Summary

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane.

Alternative names and synonyms associated with Phospholipase C gamma 2 (PLCG2)

  • phospholipase C, gamma 2 (Plcg2)
  • phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2)
  • phospholipase C, gamma 2 (phosphatidylinositol-specific) (Plcg2)
  • APLAID protein
  • FCAS3 protein
  • Plcg-2 protein
  • PLCgamma2 protein

Protein level used designations for PLCG2

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 , 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 , PLC-gamma-2 , phosphoinositide phospholipase C-gamma-2 , phospholipase C-gamma-2 , PLC-IV , phosphoinositide phospholipase C , phospholipase C-IV , phosphatidylinositol-specific phospholipase C

234779 Mus musculus
29337 Rattus norvegicus
5336 Homo sapiens
489692 Canis lupus familiaris
100518663 Sus scrofa
281988 Bos taurus
415805 Gallus gallus
100726796 Cavia porcellus
Selected quality suppliers for Phospholipase C gamma 2 Proteins (PLCG2)
Did you look for something else?