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|Application / Reactivity||Human||Chicken||Mouse (Murine)||Rat (Rattus)|
|Cytometry by Time of Flight (CyTOF)||1 Antibodies|
|Simple Western (SimWes)||1 Antibodies|
|Western Blotting (WB)||7 Antibodies||202 Antibodies||108 Antibodies||103 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Immunoprecipitation (IP)||6 Antibodies||3 Antibodies||4 Antibodies||6 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||32 Antibodies||21 Antibodies||22 Antibodies|
|Immunohistochemistry (IHC)||71 Antibodies||80 Antibodies||124 Antibodies||1 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||4 Antibodies||2 Antibodies|
|Antigen||Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Antibodies|
|Reactivity||Chicken, Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TRKB antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-TRKB AntibodyTarget Details TRKB Application Details Handling References for anti-TRKB Antibody (ABIN223287) Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412957|
|Specificity||Trk protein exists as variably glycosylated entities with the major forms having molecular weights of 140 kDa, 110 kDa, and the unglycosylated form of 80 kDa. .|
|Immunogen||Synthetic peptide surrounding amino acid 810 of human TrkB|
Target Details TRKBProduct Details anti-TRKB Antibody Application Details Handling References for anti-TRKB Antibody (ABIN223287) Images back to top
|Alternative Name||TrkB (NTRK2 Antibody Abstract)|
Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular weights of 140-145 kDa, 110 kDa and the unglycosylated form of 80 kDa. trkB contains 33.3 % carbohydrate by weight representing modification on 10 of 12 N-glycosylation sites. The primary ligand for trkB is BDNF which induces the phosphorylation of the protein and subsequent binding of PLC-gamma via SH2 domains. TrkB may function to modulate neuronal responses to the neurotrophins acting throμgh trkB such as BDNF.
Synonyms: NTRK2 , GP145-TrkB , TRKB , Trk-B , tyrosine receptor kinase
|Pathways||RTK Signaling, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-TRKB Antibody Target Details TRKB Handling References for anti-TRKB Antibody (ABIN223287) Images back to top
Western blotting (0.5-4 μg/mL), Immunofluorescence (5-10 μg/mL).
However, the optimal concentrations should be determined individually.
Country of Animal Origin: China
|Restrictions||For Research Use only|
HandlingProduct Details anti-TRKB Antibody Target Details TRKB Application Details References for anti-TRKB Antibody (ABIN223287) Images back to top
|Buffer||100 μg (0.2 mg/mL) immunoaffinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
References for anti-TRKB Antibody (ABIN223287)Product Details anti-TRKB Antibody Target Details TRKB Application Details Handling Images back to top
|Product cited in:||
Shen, Ghai, Sompol, Liu, Cao, Iuvone, Ye: "N-acetyl serotonin derivatives as potent neuroprotectants for retinas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 9, pp. 3540-5, 2012
Jang, Liu, Pradoldej, Tosini, Chang, Iuvone, Ye: "N-acetylserotonin activates TrkB receptor in a circadian rhythm." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 8, pp. 3876-81, 2010
Jang, Liu, Chan, France, Sayeed, Tang, Lin, Xiao, Andero, Chang, Ressler, Ye: "Deoxygedunin, a natural product with potent neurotrophic activity in mice." in: PLoS ONE, Vol. 5, Issue 7, pp. e11528, 2010
Jang, Liu, Yepes, Shepherd, Miller, Liu, Wilson, Xiao, Blanchi, Sun, Ye: "A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 6, pp. 2687-92, 2010
ImagesProduct Details anti-TRKB Antibody Target Details TRKB Application Details Handling References for anti-TRKB Antibody (ABIN223287) back to top