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Data suggest that amino acid residues alpha4Gly-41, alpha4Lys-64, and alpha4Thr-66 are critical for (alpha4)3(beta2)2 neuronal AChR potentiation by positive allosteric modulator (PAM (show PAM ELISA Kits)) CMPI, but not by PAM (show PAM ELISA Kits) NS9283; amino acid substitution at alpha4His-116, a known determinant of NS9283 binding and of agonist binding at alpha4:alpha4 subunit interface, did not reduce CMPI potentiation.
The form containing three copies of alpha4 and two of beta2 was potentiated at low concentrations of acetylcholine chloride (ACh (show FGFR3 ELISA Kits)) and physostigmine, whereas the form containing two copies of alpha4 and three of beta2 was inhibited.
findings indicate that alterations in expression of the alpha4beta2 subtype of nAChR (show CHRNA4 ELISA Kits) may be involved in the molecular mechanism(s) underlying the cognitive deficit associated with vascular dementia
MAFA controls autonomic nervous system-mediated insulin secretion by activating the transcription of nicotinic (ChrnB2 and ChrnB4) receptor genes, which is impaired in patients with type 2 diabetes.
the identity of subunits neighboring the otherwise equivalent alpha4(+)/(-)beta2 agonist sites modifies their contributions to nAChR (show CHRNA4 ELISA Kits) activation and E-loop residues are an important contributor to this neighbor effect
The results of this study suggested that rs2072660 had a significant effect on the nicotine dependence There was no direct association between depressive phenotype (with neither ZSDS total scores and nor its subscales) and CHRNB2 variants.
findings suggest that CHRNB2 rs4845652 T-allele carriers may be associated with lower levels of nicotine dependence (ND), and that certain allelic combinations of CHRNA4 (show CHRNA4 ELISA Kits) and CHRNB2 might be correlated with higher ND levels.
Following smoking reduction and cessation alpha4beta2* nAChR (show CHRNA4 ELISA Kits) densities were decreased across brain regions.
alpha4beta2-nAChR (show CHRNA4 ELISA Kits) is a sensitive target to mediate oligomeric alpha-synuclein (show SNCA ELISA Kits)-induced modulation of cholinergic signaling.
NMR resolved multiple anesthetic binding sites in the TM domains of the alpha4beta2 nAChR (show CHRNA4 ELISA Kits)
our results show that the beta2V287L ADNFLE mutation increases the ACh (show FGFR3 ELISA Kits) sensitivities of both HS and LS alpha4beta2 nAChRs (but not that of alpha5alpha4beta2 nAChRs).
Varenicline treatment may prevent scopolamine-induced memory disturbance by a molecular mechanism that may involve increased alpha4beta2 nAChR (show CHRNA4 ELISA Kits) availability. Varenicline dose-dependently increased protein expression of both the alpha4 and beta2 subunit in cell cultures and brain tissues, respectively, but had no effect on mRNA expression; lack of change in mRNA expression suggests a still unknown post-transcriptional me...
MAFA controls autonomic nervous system-mediated insulin secretion by activating the transcription of nicotinic (ChrnB2 and ChrnB4) receptor genes, which is impaired in type 2 diabetes.
Chrna7 (show CHRNA7 ELISA Kits)-deficient mice exhibit sustained attention impairments that are reversed by Chrnb2 activation
Phenotype of layer V pyramidal cellss in aged Chrnb2 knockout mice is the result of the interaction of aging with the absence of high-affinity nAChRs over a relatively prolonged period of life span
Lynx2 and Ly6g6e have roles in intracellular trafficking and allosteric potentiation of alpha4beta2 nAChRs, respectively
The study shows that nAChR (show CHRNA4 ELISA Kits) alpha4 beta2 sensitizes a MAPK (show MAPK1 ELISA Kits)-linked toxicity pathway on prolonged exposure to ABETA (show APP ELISA Kits) (1-42).
This experiments establish a firm causal link between Chrnb2 retinal waves, and visual circuit development and demonstrate that spontaneous retinal waves are necessary and instructive for circuit refinement in the developing nervous system
Lynx1 (show LYNX1 ELISA Kits) has a role in shifting alpha4beta2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum
Data suggest that the beta2 subunit of the nAChR (show CHRNA4 ELISA Kits) is involved in the nicotine-induced inhibition of resident macrophages in stomach.
Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.
acetylcholine receptor, nicotinic, beta 2 (neuronal)
, cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
, neuronal acetylcholine receptor subunit beta-2
, neuronal nicotinic acetylcholine receptor beta 2
, N-alpha 1
, beta-2 subunit, nicotinic acetylcholine receptor
, neuronal acetylcholine receptor non-alpha-1 chain
, neuronal acetylcholine receptor, beta 2
, cholinergic receptor nicotinic beta polypeptide 2
, cholinergic receptor, nicotinic, beta subunit 2
, acetylcholine receptor beta 2 neural