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Browse our PLA2G2A Proteins (PLA2G2A)

Full name:
phospholipase A2, Group IIA (Platelets, Synovial Fluid) Proteins (PLA2G2A)
On www.antibodies-online.com are 19 phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A) Proteins from 10 different suppliers available. Additionally we are shipping PLA2G2A Antibodies (55) and PLA2G2A Kits (30) and many more products for this protein. A total of 107 PLA2G2A products are currently listed.
Synonyms:
EF, Mom1, Pla2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2, sPla2-IIA
list all proteins Gene Name GeneID UniProt
PLA2G2A 5320 P14555
PLA2G2A 29692 P14423
PLA2G2A 18780 P31482

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PLA2G2A Proteins (PLA2G2A) by Origin

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Top referenced PLA2G2A Proteins

  1. Human PLA2G2A Protein expressed in Human Cells - ABIN2004058 : Fijneman, Cormier: The roles of sPLA2-IIA (Pla2g2a) in cancer of the small and large intestine. in Frontiers in bioscience : a journal and virtual library 2008 (PubMed)
    Show all 2 references for ABIN2004058

More Proteins for PLA2G2A Interaction Partners

Human phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A) interaction partners

  1. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (show YWHAZ Proteins), lipoxygenase and cyclooxygenase.

  2. High expression of PLA2G2A was associated with poor therapeutic response and worse survival in patients with rectal cancer receiving neoadjuvant concurrent cheomoradiotherapy (CCRT).

  3. Data show that phospholipase A2 group IIA, V and X have different target/function related activity.

  4. Polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.

  5. Overexpression of sPLA2-IIA does not alter MCP-1 (show CCL2 Proteins) level at baseline, but could enhance the atherogenic effect of oxidized LDL in HASMCs, at least partly due to activation of Akt (show AKT1 Proteins).

  6. These results suggest that the genetic ablation of iPLA2b increased iron uptake in the brain through the activation of IRP2 (show IREB2 Proteins) and upregulation of DMT1 (show DMRT1 Proteins), which may be associated with mitochondrial dysfunction.

  7. IL-22 (show IL22 Proteins) induced at an early stage of L. monocytogenes infection enhances innate immunity against L. monocytogenes in the liver by stimulating hepatocytes to produce PLA2G2A

  8. PLA2G2A was detected in all samples of endometriomas, but not in normal endometrium, and immunohistochemistry showed PLA2G2A-specific staining in epithelial cells of endometrioma paraffin sections.

  9. Results indicate that secreted phospholipase A2 IIA (sPLA (show YWHAZ Proteins)2-IIA) as an enzyme working in concert with (show ALOX12 Proteins) platelet microparticles (MPs) 12-lipoxygenase (12-LO) to promote internalization.

  10. Secretory PLA2 IIa expression can predict the clinical outcome of lung adenocarcinoma patients.

Mouse (Murine) phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A) interaction partners

  1. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (show YWHAZ Proteins), lipoxygenase and cyclooxygenase.

  2. Polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.

  3. Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2beta (iPLA2beta (show PLA2G6 Proteins)) and Group X Secreted Phospholipase A2 (show YWHAZ Proteins) (sPLA2).

  4. Data show that the coordinated action of phospholipase A2 (show YWHAZ Proteins) IIA (sPLA2-IIA) and 12-lipoxygenase (12-LO (show ALOX15 Proteins)) promotes inflammatory arthritis.

  5. Pla2g2a sequence varies between tumor resistant and sensitive mouse strains. Some of these variations in the promoter region affect Pla2g2a expression and nonsense-mediated RNA decay also contributes to reducing Pla2g2a mRNA in tumor-sensitive strains.

  6. hydrolysis of the mitochondrial membrane by sPLA2-IIA yields inflammatory mediators (ie, lysophospholipids, fatty acids, and mtDNA) that promote leukocyte activation

  7. Ionomycin causes susceptibility to phospholipase A2 while temperature-induced increases in membrane fluidity fail: possible involvement of actin fragmentation.

  8. two of these isoforms, sPLA2 IIA and sPLA2 IIF (show PLA2G2F Proteins), localize to the upper stratum granulosum and increase in response to experimental barrier perturbation.

  9. Investigation into the role of phosphatidylserine in modifying the susceptibility of lymphocytes to secretory phospholipase A(2) using cells deficient in the expression of scramblase.

  10. Data show changes in cell morphology and upregulation of ERK1/2, iNOS and sPLA-IIA expression in astrocytes and microglia on exposure to lipopolysaccharides and cytokines.

Guinea Pig phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A) interaction partners

  1. PLA2G2A production is induced by Pseudomonas aeruginosa.

PLA2G2A Protein Profile

Protein Summary

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.

Alternative names and synonyms associated with PLA2G2A

  • phospholipase A2, group IIA (platelets, synovial fluid) (PLA2G2A)
  • phospholipase A2, group IIA (platelets, synovial fluid) (Pla2g2a)
  • EF protein
  • Mom1 protein
  • Pla2 protein
  • PLA2B protein
  • PLA2L protein
  • PLA2S protein
  • PLAS1 protein
  • sPLA2 protein
  • sPla2-IIA protein

Protein level used designations for PLA2G2A

GIIC sPLA2 , NPS-PLA2 , group IIA phospholipase A2 , non-pancreatic secretory phospholipase A2 , phosphatidylcholine 2-acylhydrolase 2A , phospholipase A2, membrane associated , eted enzyme type IIA phospholipase A2 , platelet phospholipase A2 , enhancing factor , modifier of Min1 , non-pancreatic secreted type II phospholipase A2 , secretory group II phospholipase A2 , typeII phospholipase A2

GENE ID SPECIES
5320 Homo sapiens
29692 Rattus norvegicus
18780 Mus musculus
521383 Bos taurus
100135599 Cavia porcellus
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