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PR Domain Containing 16 ELISA Kits (PRDM16)
On are 1 PR Domain Containing 16 (PRDM16) ELISA Kits from 1 different suppliers available. Additionally we are shipping PRDM16 Antibodies (69) and PRDM16 Proteins (11) and many more products for this protein. A total of 85 PRDM16 products are currently listed.
5730557K01Rik, C130091E20, csp1, mel1, mKIAA1675, PFM13, PRDM16, wu:fc09g08
list all ELISA KIts Gene Name GeneID UniProt
Human PRDM16 PRDM16 63976 Q9HAZ2
PRDM16 70673 A2A935
Rat PRDM16 PRDM16 100366024  

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Zebrafish PR Domain Containing 16 (PRDM16) interaction partners

  1. Prdm3 (show MECOM ELISA Kits) and prdm16 are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Cow (Bovine) PR Domain Containing 16 (PRDM16) interaction partners

  1. Animals with the homozygote PRDM16 genotype had lower body weight and average daily gain than those with the other genotypes.

  2. The genetic variation within PRDM16 gene in 1031 Chinese indigenous bovine, was analyzed.

Human PR Domain Containing 16 (PRDM16) interaction partners

  1. Flow cytometric analysis and western blot analysis of apoptosisassociated proteins indicated that PRDM16 has an antiapoptotic role in prostatic cancer cells. In addition, the spliced form, sPRDM16/MEL1S, was detected to be overexpressed in PCa (show FLVCR1 ELISA Kits) cell lines. In conclusion, the present study indicated an important oncogenic role in prostate cancer.

  2. A single risk variant, rs2651899 in PRDM16, was significantly associated with efficacy of triptans in migraine patients

  3. High PRDM16 expression is associated with astrocytoma.

  4. Our results suggest that K568 SUMOylation of sPRDM16 plays an important role in the progression of acute myeloid leukemia (show BCL11A ELISA Kits).

  5. Results show that PRDM16 overexpression was highly recurrent in de novo paediatric AML (show RUNX1 ELISA Kits) and is associated with adverse outcome

  6. PRDM16 might contribute to maintain adipose tissue "white fat" gene expression profile and systemic metabolic homeostasis.

  7. EVI1 (show MECOM ELISA Kits) and MEL1 are homolog genes whose transcriptional activations by chromosomal translocations have roles in Japanese pediatric acute myeloid leukemia (show BCL11A ELISA Kits)

  8. Three novel loci were identified in East Asians with cardiac arrhythmias: rs2483280 (PRDM16 locus) and rs335206 (PRDM6 (show PRDM6 ELISA Kits) locus) were associated with QRS (show QARS ELISA Kits) duration; and rs17026156 (SLC8A1 (show SLC8A1 ELISA Kits) locus) correlated with PR interval.

  9. Genetic analyses uncovered the importance of the PRDM16 gene in the regulation of lean body mass.

  10. MED1 (show MED1 ELISA Kits) is required for optimal PRDM16-induced Ucp1 (show UCP1 ELISA Kits) expression

Mouse (Murine) PR Domain Containing 16 (PRDM16) interaction partners

  1. Both gain- and loss-of-function studies showed that an accumulation of the CCAAT/enhancer binding protein-beta (C/EBP-beta (show CEBPB ELISA Kits)) protein, which cooperates with dominant transcriptional co-regulator PR domain containing 16 (PRDM16) to determine brown/beige (show LYST ELISA Kits) adipocyte lineage, is essential for the enhanced adipocyte browning caused by the loss of ZIP13 (show SLC39A13 ELISA Kits)

  2. Prdm16 plays an important role in dynamic cellular redox changes in developing neocortex during neural differentiation.

  3. Together, these data indicate that PRDM16 diminishes responsiveness to type I interferon (show IFNA ELISA Kits) in adipose cells to promote thermogenic and mitochondrial function.

  4. the cellular levels of alpha-ketoglutarate (alphaKG), a key metabolite required for TET-mediated DNA demethylation, were profoundly increased and required for active DNA demethylation of the Prdm16 promoter.

  5. We further show that Cdkn1c (show CDKN1C ELISA Kits) is required for post-transcriptional accumulation of the brown fat determinant PR domain containing 16 (PRDM16) and that CDKN1C (show CDKN1C ELISA Kits) and PRDM16 co-localise to the nucleus of rare label-retaining cell within iBAT (show SLC10A2 ELISA Kits).

  6. PRDM16-induced C2C12 transdifferentiation is associated with alterations in CpG methylation of myogenic factors, and PR domain affects both myogenesis and adipogenesis with modified histone methylation marks on MyoD (show MYOD1 ELISA Kits) and PPARgamma (show PPARG ELISA Kits) promoters

  7. PRDM16 deficiency in BAT (show BAAT ELISA Kits) reduces MED1 (show MBD4 ELISA Kits) binding at PRDM16 target sites and causes a fundamental change in chromatin architecture at key brown fat-selective genes

  8. Prdm16 and Prdm3 (show MECOM ELISA Kits) control postnatal BAT (show BAAT ELISA Kits) identity and function.

  9. Study reveals that Prdm16 expression is regulated through Gcn5 (show KAT2A ELISA Kits)/PCAF (show KAT2B ELISA Kits) during brown adipogenesis.

  10. these studies define the transcriptional pathways involved in HOXB4 (show HOXB4 ELISA Kits) HSC (show FUT1 ELISA Kits) expansion in vivo and identify repression of Prdm16 transcription as a mechanism by which expanding HSCs avoid leukemic transformation.

PRDM16 Antigen Profile

Antigen Summary

The reciprocal translocation t(1\;3)(p36\;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with PRDM16

  • PR domain containing 16 (PRDM16) Elisa Kit
  • PR domain containing 16 (prdm16) Elisa Kit
  • PR domain containing 16 (Prdm16) Elisa Kit
  • 5730557K01Rik Elisa Kit
  • C130091E20 Elisa Kit
  • csp1 Elisa Kit
  • mel1 Elisa Kit
  • mKIAA1675 Elisa Kit
  • PFM13 Elisa Kit
  • PRDM16 Elisa Kit
  • wu:fc09g08 Elisa Kit

Protein level used designations for PRDM16

PR domain containing 16 , fc09g08 , PR domain zinc finger protein 16-like , MDS1/EVI1-like gene 1 , PR domain zinc finger protein 16 , transcription factor MEL1 , PR domain-containing protein 16 , line 27

419388 Gallus gallus
457227 Pan troglodytes
559174 Danio rerio
100060844 Equus caballus
100137803 Bos taurus
100481590 Ailuropoda melanoleuca
100592850 Nomascus leucogenys
63976 Homo sapiens
70673 Mus musculus
100366024 Rattus norvegicus
479582 Canis lupus familiaris
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