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Human Monoclonal SPI1 Primary Antibody for IP, WB - ABIN967452
Klemsz, McKercher, Celada, Van Beveren, Maki: The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. in Cell 1990
Show all 7 Pubmed References
Human Polyclonal SPI1 Primary Antibody for ELISA, WB - ABIN314238
Harendza, Lovett, Stahl: The hematopoietic transcription factor PU.1 represses gelatinase A transcription in glomerular mesangial cells. in The Journal of biological chemistry 2000
Show all 2 Pubmed References
Human Monoclonal SPI1 Primary Antibody for FACS, ELISA - ABIN3072909
Xu, Wang, Wang, Wu, Zhao, Zhu, Qiu, Xue, Shao, Guo, Li: PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60. in Leukemia research 2010
Human Polyclonal SPI1 Primary Antibody for WB - ABIN4240538
McDevit, Nikolajczyk: Changes in immunoglobulin-nucleoprotein complex structure mapped by chromatin immunoprecipitation. in Molecular immunology 2006
The analysis points to a critical role for Hoxa9 (show HOXA9 Antibodies) and PU.1 in distal regulation of c-myb (show MYB Antibodies) expression in murine myeloid cells during iL-6 (show IL6 Antibodies)-induced cell differentiation.
These studies reveal an important role for PU.1 in the regulation of Igkappa transcription and rearrangement and a requirement for PU.1 and Spi-B (show SPIB Antibodies) in B cell development.
expression of an essential mediator of neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased in Hbb(th3/+) neutrophils in a model of beta-thalassemia
Moreover, the expression of a cell proliferation marker Ki67 (show MKI67 Antibodies) was significantly decreased in tumors from the mice not taking doxycycline, compared with that of tumors from the mice continuously taking doxycycline. The present data strongly suggest that PU.1 functions as a tumor suppressor of myeloma cells in vivo.
the affinities of two sequence-divergent ETS (show ETS1 Antibodies) homologs, PU.1 and Ets-1 (show ETS1 Antibodies), to DNA sites harboring a hemi- and fully methylated CpG dinucleotide, were measured.
this study shows that PU.1 functions as a positive regulator of CD11c (show ITGAX Antibodies) gene expression by directly binding to the Itgax (show ITGAX Antibodies) promoter and through transactivation of the Irf4 (show IRF4 Antibodies) gene
Here we demonstrate that the transcription factors SPI1 (PU.1) and HOXC13 synergistically regulate Zfp521 (show ZNF521 Antibodies) expression, and identify the regions of the Zfp521 (show ZNF521 Antibodies) promoter required for this transcriptional activity. We also show that SPI1 and HOXC13 activate Zfp521 (show ZNF521 Antibodies) in a dose-dependent manner.
findings suggest that Gata1 (show GATA1 Antibodies) & PU.1 transcription factors are only executing and reinforcing lineage choice once made. These results challenge the current prevailing model of early myeloid lineage choice
involved in osteoclast development by transactivating NFATc1 (show NFATC1 Antibodies) expression via direct binding to the NFATc1 (show NFATC1 Antibodies) promoter
GATA1 (show GATA1 Antibodies) and PU.1 bind in vitro and in vivo the proximal promoter region of the RPS19 (show RPS19 Antibodies) gene which is frequently mutated in Diamond-Blackfan Anemia.
PU.1-induced apoptosis in myeloma cells is associated with IRF4 (show IRF4 Antibodies) downregulation and subsequent IRF7 (show IRF7 Antibodies) upregulation.
Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (show CD68 Antibodies) (6 of 7 cases), CD163 (show CD163 Antibodies) (5 of 5 cases), and PU.1 (3 of 4 cases).
findings highlight a unique role of SPI1 fusions in high-risk pediatric T cell acute lymphoblastic leukemia
expression of an essential mediator of neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased in Hbb(th3/+) neutrophils in beta-thalassemia
RUNX1 (show RUNX1 Antibodies) overexpression induced partial DNA demethylation at SPI1 proximal promoter.
This study demonstrated the novel role of PU.1 in the immune response to A. fumigatus through upregulation of Dectin-1 (show CLEC7A Antibodies) expression and its translocation to the nucleus in A. fumigatus-stimulated THP-1 (show GLI2 Antibodies) cells.
PU.1 is an important modulator of VDR (show CYP27B1 Antibodies) signaling in monocytes.
Forced FOG1 (show ZFPM1 Antibodies) protein expression in K562 erythroleukemia cells induced the expression of SLC4A1 (show SLC4A1 Antibodies) protein, but repressed that of transcription factor PU.1.
we demonstrated that miR (show MLXIP Antibodies)-22 promoted monocyte/macrophage differentiation, and MECOM (EVI1 (show MECOM Antibodies)) mRNA is a direct target of miR (show MLXIP Antibodies)-22 and MECOM (EVI1 (show MECOM Antibodies)) functions as a negative regulator in the differentiation.The miR (show MLXIP Antibodies)-22-mediated MECOM (show MECOM Antibodies) degradation increased c-Jun (show JUN Antibodies) but decreased GATA2 (show GATA2 Antibodies) expression, which results in increased interaction between c-Jun (show JUN Antibodies) and PU.1
The vertical and paralleled Pu.1/Spi-b (show SPIB Antibodies) regulatory networks control the development of rostral blood island and ventral wall of dorsal aorta-borne macrophages by regulating Irf8 (show IRF8 Antibodies).
eaf1 (show EAF1 Antibodies) has a role in suppressing foxo3b expression to modulate transcriptional activity of gata1 (show GATA1 Antibodies) and spi1 in primitive hematopoiesis
Our results indicate that Kzp (show ANPEP Antibodies) is a critical transcriptional factor for the expression of gata2 and pu.1 to modulate primitive hematopoiesis.
Runx1 (show RUNX1 Antibodies) is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.
The authors show that tif1gamma (show TRIM33 Antibodies) modulates the erythroid versus myeloid fate outcomes from HSCs by differentially controlling the levels of gata1 (show GATA1 Antibodies) and pu.1.
found a gene group downregulated on spi1 knockdown,containing all 5 previously identified Spi1-dependent genes as well as a large set of novel immune-related genes
In zebrafish, spi1 marks a rostral population of LPM cells committed to a myeloid fate anatomically separated from and developmentally independent of erythroid commitment in the caudal (show CAD Antibodies) LPM.
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
, contrapsin-like protease inhibitor 3
, contrapsin-like protease inhibitor-related protein
, liver regeneration protein lrryan
, serine protease inhibitor 1
, serine protease inhibitor 2.1
, serine protease inhibitor 2a
, serine protease inhibitor A3L
, serpin A3L
, 31 kDa transforming protein
, 31 kDa-transforming protein
, SPI-1 proto-oncogene
, hematopoietic transcription factor PU.1
, spleen focus forming virus (SFFV) proviral integration oncogene spi1
, transcription factor PU.1
, SFFV proviral integration 1 protein
, SFFV proviral integration 1
, spleen focus forming virus proviral integration oncogene spi1
, Spi-1/PU.1 transcription factor
, transcription factor spi1