Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species
We conclude that residues in the M2 segment and flanking regions contribute to the unusual properties of the CHRNA7 receptor
Loop 3 and its docking to the alpha-helix is an important requirement for receptor assembly of the alpha7 nicotinic receptor.
a network of interactions formed by residues Lys (show LYZ ELISA Kits)-46, Asp (show ASIP ELISA Kits)-128, Asp (show ASIP ELISA Kits)-135, Asp (show ASIP ELISA Kits)-266, and possibly others appears to link agonist binding to channel gating
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.
neuronal acetylcholine receptor subunit alpha-7
, neuronal acetylcholine receptor subunit alpha-7-like
, cholinergic receptor, nicotinic, alpha 7
, alpha 7 nicotinic acetylcholine receptor
, cholinergic receptor, nicotinic, alpha polypeptide 7