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TTBK2 (show TTBK2 Proteins) down-regulates GluK2 activity by decreasing the receptor protein abundance in the cell membrane via RAB5 (show RAB5A Proteins)-dependent endocytosis.
In the Han population in Central China, the polymorphisms of SNP rs9390754 in the GRIK2 gene may be associated with epilepsy susceptibility.
Study demonstrates that co-assembly of recombinant kainate receptors (GluK1 (show GRIK1 Proteins) and GluK2) with the Neto1 (show NETO1 Proteins) and Neto2 (show NETO2 Proteins) auxiliary subunits alters their onset and recovery from desensitization in a subunit-dependent manner
This study found in GRIK2 (glutamate (show GRIN1 Proteins) receptor, ionotropic kainate 2) was most significant and also showed significant correlations with gene expression.
This study showed that Gluk2 association with obsessive-compulsive disorder.
Parkin interac (show PARK2 Proteins)ts with the kainate receptor GluK2 subunit and regulates KAR function.
High risk genetic markers of paranoid schizophrenia were GRIK2*ATG and GRIK2*TGG in Tatars.
The present study reveals an additional mechanism for the regulation of GluK2-containing kainate receptors by Src (show SRC Proteins) family kinases, which may be of pathological significance in ischemic stroke.
we found no association between rs1556995 in GRIK2 and clozapine-induced obsessive-compulsive (OC) symptoms, implying that that GRIK2 may not play a role in the development of OC symptoms in schizophrenia patients
14-3-3 (show YWHAQ Proteins) proteins are an important regulator of GluK2a-containing KARs (show KARS Proteins) and may contribute to the slow decay kinetics of native KAR (show HSD17B12 Proteins)-EPSCs.
GluK2-mediated increase in KCC2 (show SLC12A5 Proteins) recycling to the surface membrane translates to a hyperpolarization of the reversal potential for GABA (EGABA).
Loss of parkin (show PARK2 Proteins) function in primary cultured neurons causes GluK2 protein to accumulate in the plasma membrane.
Interictal and ictal discharges are minimized in mice lacking the GluK2 subunit.
This study demonistrated that grik2 gene expression in mouse dorsal raphe nucleus
The results show that NETO2 (show NETO2 Proteins) is a kainate receptor subunit with significant effects on glutamate (show GRIN1 Proteins) signaling mechanisms in brain.
GluR6 kainate receptors are critically involved in inhibiting transmission at both A delta and C fibre monosynaptic pathways. Presynaptic GluR5 (show GRIK1 Proteins) kainate receptors play limited role in inhibiting C fibre-activated pathway.
Using kainate receptor knock-out mice, we show that subunits glutamate (show GRIN1 Proteins) receptor (GluR) 5 (show GRIK1 Proteins) and GluR6 play distinct roles in kainate-induced gamma oscillations and epileptiform burst activity.
The facilitatory effects of kainate on mossy fiber synaptic transmission and plasticity are mediated by GLU (show GCG Proteins)(K6)-containing kainate receptors.
In the present study, we used knock-out mice to explore the contribution of GluR5 (show GRIK1 Proteins) and GluR6 receptors to sensory responses, fear memory, and learning-related synaptic potentiation in the amygdala.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.
glutamate receptor 6
, glutamate receptor, ionotropic kainate 2
, glutamate receptor, ionotropic, kainate 5
, excitatory amino acid receptor 4
, glutamate receptor form A
, glutamate receptor form B
, glutamate receptor form C
, glutamate receptor form D
, glutamate receptor form E
, glutamate receptor ionotropic, kainate 2
, gluR beta-2
, glutamate receptor beta-2
, glutamate receptor, ionotropic, kainate 2