Browse our SNCA (SNCA) ELISA Kits

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Synuclein, alpha ELISA Kits (SNCA)
On are 70 Synuclein, alpha (SNCA) ELISA Kits from 16 different suppliers available. Additionally we are shipping SNCA Antibodies (753) and SNCA Proteins (75) and many more products for this protein. A total of 923 SNCA products are currently listed.
alphaSYN, LOC619283, MGC64356, NACP, PARK1, PARK4, PD1, snca

Top referenced SNCA ELISA Kits

  1. Human SNCA ELISA Kit for Sandwich ELISA - ABIN414578 : Alvarez-Erviti, Seow, Schapira, Gardiner, Sargent, Wood, Cooper: Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. in Neurobiology of disease 2011 (PubMed)
    Show all 4 references for 414578

  2. Mouse (Murine) SNCA ELISA Kit for Sandwich ELISA - ABIN415770 : Fanara, Wong, Husted, Liu, Liu, Kohlstaedt, Riiff, Protasio, Boban, Killion, Killian, Epling, Sinclair, Peterson, Price, Cabin, Nussbaum, Brühmann, Brandt, Christine, Aminoff, Hellerstein: Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration. in The Journal of clinical investigation 2012 (PubMed)
    Show all 3 references for 415770

More ELISA Kits for SNCA Interaction Partners

Xenopus laevis Synuclein, alpha (SNCA) interaction partners

  1. study examined the spatial and temporal expression patterns of three synuclein genes (snca, sncbb, sncg (show SNCG PLURAL_@30212@)) during embryogenesis

Mouse (Murine) Synuclein, alpha (SNCA) interaction partners

  1. Data suggest that endocytosis is the principal mechanism by which proteopathic alpha-synuclein aggregates are internalized in primary hippocampal neurons in culture; aggregates are rapidly trafficked along endosomal/lysosomal pathway, where most of the material remains for days as proposed in neurodegenerative synucleinopathies.

  2. LRRK2 (show LRRK2 ELISA Kits) negatively regulates the clearance of alphaSYN accompanied by down-regulation of the endocytosis pathway; LRRK2 (show LRRK2 ELISA Kits) in microglia may function as the offending molecule responsible for neurodegeneration, in terms of down-regulation of alphaSYN clearance.

  3. sideroflexin 3 (SFXN3 (show SFXN3 ELISA Kits)) was found to be a mitochondrial protein (show COX6B2 ELISA Kits) localized to the inner mitochondrial membrane.

  4. The ability of monomeric alpha-synuclein to enhance ATP synthase efficiency under physiological conditions may be of importance when alpha-synuclein undergoes the misfolding and aggregation

  5. Rab7 (show RAB7A ELISA Kits) accumulated in GCase (show GBA ELISA Kits) deficient cells, supporting the notion that lysosomal recycling is impaired. Since recombinant GCase (show GBA ELISA Kits) can reverse ALR (show GFER ELISA Kits) impairment, we anticipate that strategies to restore GCase (show GBA ELISA Kits) activity in the brains of both sporadic patients with PD and those with GBA1 (show GBA ELISA Kits) mutations will improve autophagy lysosomal pathway, preventing the accumulation of a-synuclein and spread of pathology.

  6. Study showed that apoptosis is an important form of cellular degeneration in lipopolysaccharide (LPS-sensitized hypoxic-ischemic (HI) injury in the immature brain. Loss of PINK1 can protect the immature brain against cell apoptosis induced by LPS-sensitized HI injury. Moreover, alpha-Syn plays a neuroprotective role in LPS-sensitized HI brain damage in PINK1-knockout neonatal mice

  7. Genetic manipulation of sirtuin 2 (show SIRT2 ELISA Kits) levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.

  8. These results indicate that fragmented amyloid-like aggregates of short alpha-syn fibrils are the key pathogenic seeds that trigger prion (show PRNP ELISA Kits)-like conversion.

  9. In summary, we have combined multiple data sets to identify transcripts, which are strong candidates for being phenotypic modifiers, and demonstrated SNCA is a modifier of pathology in motor neuron disease.

  10. In alpha-synuclein knock-out mice there was a decrease in neuronal glucose metabolism in cerebral cortex gray matter.

Human Synuclein, alpha (SNCA) interaction partners

  1. Study suggests histones as prime candidates for one of the nuclear proaggregant factors involved in the formation of transmissible alpha-synuclein aggregates during neuron apoptosis.

  2. Study provides evidence that phosphorylated alpha-synuclein deposition is present in dermal nerve fibers in a subgroup of patients suffering from REM (show REM1 ELISA Kits) sleep behavior disorder, presumably representing prodromal Parkinson's disease.

  3. This review describes the major findings supporting the occurrence of alpha-synuclein pathology propagation in Parkinson's disease and discusses how this phenomenon could induce or contribute to synaptic injury and degeneration. [Review]

  4. This review evaluated major classes of molecular chaperones and their mechanisms relevant for preventing protein aggregation, specific case of alpha-synuclein aggregation. [review]

  5. Data suggest that endocytosis is the principal mechanism by which proteopathic alpha-synuclein aggregates are internalized in primary hippocampal neurons in culture; aggregates are rapidly trafficked along endosomal/lysosomal pathway, where most of the material remains for days as proposed in neurodegenerative synucleinopathies.

  6. Data suggest that endocytosis and lysosomal processing of proteopathic alpha-synuclein aggregates in neurons are consistent with models of neurodegeneration in synucleinopathies. [EDITORIAL]

  7. These results indicate that LRRK2 (show LRRK2 ELISA Kits) and alpha-synuclein participate in the dysregulation of CADPS2 (show CADPS2 ELISA Kits) by altering transcription and support the hypothesis that synaptic dysfunctions, through different mechanisms, might contribute to the neuronal defects of diseases such as Parkinson's disease.

  8. Increasing evidence supports that small alpha-synuclein aggregates or oligomers may be the real culprit, causing deficits in neurotransmission and neurogenesis in the hippocampus and related brain regions, which constitute the major mechanism for the hippocampal dysfunctions and associated neuropsychiatric manifestations in synucleinopathies. [alpha-synuclein]

  9. Most anti-PD1 (show PDCD1 ELISA Kits)-related adrenal insufficiency cases involved an isolated ACTH (show POMC ELISA Kits) deficiency. Eosinophilia may be an early indicator before the onset of symptoms.

  10. Significantly higher transcript expression levels of PD1 (show PDCD1 ELISA Kits) were found in tumor tissue, whilst a general increase in PDL1 (show CD274 ELISA Kits) expression was found in tumor tissues, although this did not reach statistical significance. Our study demonstrates higher levels of expression of PDL1 (show CD274 ELISA Kits) are associated with favorable clinical outcome.

Cow (Bovine) Synuclein, alpha (SNCA) interaction partners

  1. analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 ELISA Kits) [ANXB12]

  2. Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.

SNCA Antigen Profile

Antigen Summary

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Alternative names and synonyms associated with SNCA

  • synuclein, alpha (snca) Elisa Kit
  • alpha-synuclein (LOC619283) Elisa Kit
  • alpha-synuclein (LOC100359228) Elisa Kit
  • synuclein, alpha (Snca) Elisa Kit
  • synuclein, alpha (non A4 component of amyloid precursor) (SNCA) Elisa Kit
  • synuclein, alpha (non A4 component of amyloid precursor) (Snca) Elisa Kit
  • alphaSYN Elisa Kit
  • LOC619283 Elisa Kit
  • MGC64356 Elisa Kit
  • NACP Elisa Kit
  • PARK1 Elisa Kit
  • PARK4 Elisa Kit
  • PD1 Elisa Kit
  • snca Elisa Kit

Protein level used designations for Synuclein, alpha (SNCA) ELISA Kits

synuclein, alpha , alpha-synuclein , alpha SYN , non-A beta component of AD amyloid , non-A4 component of amyloid , non A-beta component of AD amyloid , synuclein alpha-140 , alpha synuclein

380315 Xenopus laevis
619283 Takifugu rubripes
100359228 Oryctolagus cuniculus
20617 Mus musculus
6622 Homo sapiens
29219 Rattus norvegicus
641350 Sus scrofa
282857 Bos taurus
395393 Gallus gallus
100294604 Ovis aries
Selected quality suppliers for SNCA (SNCA) ELISA Kits
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