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anti-Rat (Rattus) BCL10 antibody for Immunofluorescence

Recommended BCL10 Antibody (supplied by: Log in to see )

Antigen
B-Cell CLL/lymphoma 10 (BCL10) Antibodies
  • AI132454
  • BCL-10
  • BCL10
  • c-E10
  • C81403
  • CARMEN
  • cE10
  • CIPER
  • CLAP
  • mE10
  • ME10
Reactivity
Human, Mouse (Murine), Rat (Rattus)
301
65
38
1
1
Host
Rabbit
175
123
4
Clonality
Polyclonal
Conjugate
This BCL10 antibody is un-conjugated
12
9
9
7
6
5
4
4
4
4
4
4
4
4
4
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
241
127
125
111
95
91
75
58
43
11
4
2
1
Supplier
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Catalog No. ABIN2403894
€ 560.48
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.001079923 ABIN303359 IF IHC (p) WB Rabbit N-Term Log in to see Polyclonal
0.001079923 ABIN3197908 IC IF WB Rabbit Log in to see Polyclonal
0.001079923 ABIN2989202 ICC IF IHC WB Rabbit IgG Log in to see Polyclonal
0.001079923 ABIN4283295 ELISA ICC IF WB Rabbit Log in to see Polyclonal

Similar anti-BCL10 Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 12 Antibodies 33 Antibodies
Immunocytochemistry (ICC) 6 Antibodies 22 Antibodies
Immunofluorescence (IF) 5 Antibodies 26 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies 11 Antibodies
Immunohistochemistry (IHC) 11 Antibodies 33 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 7 Antibodies 24 Antibodies
Western Blotting (WB) 28 Antibodies 54 Antibodies
Enzyme Immunoassay (EIA) 2 Antibodies
Flow Cytometry (FACS) 21 Antibodies

General

Antigen B-Cell CLL/lymphoma 10 (BCL10) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(301), (65), (38), (1), (1)
Host Rabbit
(175), (123), (4)
Clonality
Polyclonal
Conjugate This BCL10 antibody is un-conjugated
(12), (9), (9), (7), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
(241), (127), (125), (111), (95), (91), (75), (58), (43), (11), (4), (2), (1)
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Product Details anti-BCL10 Antibody

Target Details BCL10 Application Details Handling Images
Purification Antigen affinity purification
Immunogen Recombinant protein of human BCL10
Isotype IgG

Target Details BCL10

Product Details anti-BCL10 Antibody Application Details Handling Images back to top
Antigen
Alternative Name BCL10 (BCL10 Antibody Abstract)
Background Bcl10/CIPER/CLAP/mE10 is a widely expressed CARD (caspase recruitment domain) containing protein shown to induce apoptosis and activate NF-κB (1-5). The CARD domain mediates self-oligomerization, interactions with other CARD proteins and is necessary for NF-κB activation, although the precise mechanism which Bcl10 regulates these processes is not fully understood. The discovery of Bcl10 came from observations of the chromosomal translocation t(1,14)(p22,q32) from B cell lymphomas of the mucosa-associated lymphoid tissue (MALT) (1,5). This translocation results in deregulated expression of a truncated form of Bcl10 which lacks apoptotic activity and enhances transformation. Studies from Bcl10 deficient mice demonstrate that Bcl10 is essential for the activation of NF-κB by T- and B-cell receptors (6). One third of Bcl10 deficient mice developed lethal exencephaly. Surviving mice were unaffected by various apoptotic stimuli, but were severely immunodeficient and defective in antigen receptor-induced NF-κB activiation. PKC or T-cell receptor signaling results in a downregulation of Bcl10 protein levels, attenuating both NF-κB activation and cellular proliferation and also provides a negative feedback regulation of the NF-κB signaling to T cell signaling (7).
Synonyms: BCL10,CARMEN,CIPER,CLAP,c-E10,mE10 ,
Molecular Weight Observed MW: 26kDa
Research Area Cancer
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway

Application Details

Product Details anti-BCL10 Antibody Target Details BCL10 Handling Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-BCL10 Antibody Target Details BCL10 Application Details Images back to top
Format Liquid
Handling Advice Avoid freeze / thaw cycles.
Storage -20 °C/-80 °C
Storage Comment Store at -20°C (regular) and -80°C (long term).

Images

Product Details anti-BCL10 Antibody Target Details BCL10 Application Details Handling back to top
Supplier Images
Immunofluorescence (IF) image for anti-BCL10 antibody (B-Cell CLL/lymphoma 10) (ABIN2403894) Immunofluorescence analysis of A549 cell using BCL10 antibody. Blue: DAPI for nuclear...
Immunohistochemistry (IHC) image for anti-BCL10 antibody (B-Cell CLL/lymphoma 10) (ABIN2403894) Immunohistochemistry of paraffin-embedded human breast cancer using BCL10 antibody at...
Western Blotting (WB) image for anti-BCL10 antibody (B-Cell CLL/lymphoma 10) (ABIN2403894) Western blot analysis of extracts of various cell lines, using BCL10 antibody.