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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||163 Antibodies||38 Antibodies||27 Antibodies|
|Immunoprecipitation (IP)||15 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||46 Antibodies||10 Antibodies||7 Antibodies|
|Immunohistochemistry (IHC)||72 Antibodies||19 Antibodies||11 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies||12 Antibodies||12 Antibodies|
|Immunofluorescence (IF)||37 Antibodies|
|Antigen||B-Cell CLL/lymphoma 10 (BCL10) Antibodies|
|Epitope||AA 5-19 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This BCL10 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-BCL10 AntibodyTarget Details BCL10 Application Details Handling Images
|Specificity||This antibody recognises B-cell CLL/lymphoma 10 (BCL10).|
|Immunogen||Synthetic Peptide corresponding to Amino acids 5-19 of human BLC10.|
Target Details BCL10Product Details anti-BCL10 Antibody Application Details Handling Images back to top
|Alternative Name||Bcl-10 (BCL10 Antibody Abstract)|
|Background||Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-kB activation. Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy. Bcl10 is expressed in many human and murine tissues and cell lines.Synonyms: B-cell CLL/lymphoma 10, BCL10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, CLAP, Cellular homolog of vCARMEN, Cellular-E10, Mammalian CARD-containing adapter molecule E10, c-E10, cCARMEN, hCLAP, mE10|
|Pathways||TCR Signaling, Fc-epsilon Receptor Signaling Pathway|
Application DetailsProduct Details anti-BCL10 Antibody Target Details BCL10 Handling Images back to top
Immunohistochemistry on Paraffin Sections (10 μg/mL). Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-BCL10 Antibody Target Details BCL10 Application Details Images back to top
|Buffer||PBS with 0.02 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||DO NOT FREEZE!!|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|
ImagesProduct Details anti-BCL10 Antibody Target Details BCL10 Application Details Handling back to top