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anti-Dog (Canine) CBL antibody for Immunoprecipitation

Recommended CBL Antibody (supplied by: Log in to see )

Antigen
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antibodies
  • 4732447J05Rik
  • C-CBL
  • c-Cbl
  • c-cbl-like
  • cbl
  • Cbl-2
  • CBL2
  • FRA11B
  • NSLL
  • RGD1561386
  • RNF55
Epitope
AA 595-810
47
40
26
23
17
5
5
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
250
136
129
5
4
4
3
1
1
1
Host
Mouse
203
35
17
1
Clonality
Monoclonal
Conjugate
This CBL antibody is un-conjugated
7
7
7
7
6
5
5
5
5
5
5
5
4
2
2
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
170
71
68
55
54
33
17
17
6
5
4
3
3
1
1
1
1
1
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Catalog No. ABIN967970
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00089556724 ABIN967971 IF IP IHC WB Mouse IgG1 AA 595-810 Log in to see 17-c 5

Top referenced anti-CBL antibody for Immunoprecipitation

Similar anti-CBL Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Dog (Canine) Chicken
Western Blotting (WB) 168 Antibodies 79 Antibodies 75 Antibodies 6 Antibodies 3 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies
Intracellular Staining (ICS) 5 Antibodies 3 Antibodies
Immunoprecipitation (IP) 20 Antibodies 5 Antibodies 5 Antibodies 2 Antibodies 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 33 Antibodies 23 Antibodies 23 Antibodies
Immunohistochemistry (IHC) 72 Antibodies 37 Antibodies 37 Antibodies 3 Antibodies

General

Antigen Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antibodies
Epitope AA 595-810
(47), (40), (26), (23), (17), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(250), (136), (129), (5), (4), (4), (3), (1), (1), (1)
Host Mouse
(203), (35), (17), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CBL antibody is un-conjugated
(7), (7), (7), (7), (6), (5), (5), (5), (5), (5), (5), (5), (4), (2), (2)
Application Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(170), (71), (68), (55), (54), (33), (17), (17), (6), (5), (4), (3), (3), (1), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-CBL Antibody

Target Details CBL Application Details Handling References for anti-CBL Antibody (ABIN967970) Images
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human c-Cbl aa. 595-810
Clone 17-c
Isotype IgG1

Target Details CBL

Product Details anti-CBL Antibody Application Details Handling References for anti-CBL Antibody (ABIN967970) Images back to top
Antigen
Alternative Name c-Cbl (CBL Antibody Abstract)
Background Cbl was identified in the genome of a transforming retrovirus from a mouse pre-B cell lymphoma. The product of mammalian c-cbl, p120[cbl], is a widely expressed cytoplasmic protein with several distinctive domains including a RING finger motif and a large proline-rich domain. Although the normal cellular function of c-Cbl has not yet been determined, it associates with many well known signal transduction proteins. In lymphoid cells, c-Cbl is a substrate of TCR-activated protein tyrosine kinases. In addition, stimulation with EGF, PDGF, FGF, or NGF results in tyrosine-phosphorylation of c-Cbl in lymphoid and other cell types. It forms a signaling complex with Grb2 in T cells and is a SH3 and SH2 binding protein which associates with many other cytoplasmic signaling proteins including Btk, Src, fyn, lck, and the beta isoform of PI-3 kinase. Thus, c-Cbl may be an important adaptor protein in growth factor and T-cell receptor signaling pathways. This antibody is routinely tested by western blot analysis.
Molecular Weight 120 kDa
Pathways TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway

Application Details

Product Details anti-CBL Antibody Target Details CBL Handling References for anti-CBL Antibody (ABIN967970) Images back to top
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only

Handling

Product Details anti-CBL Antibody Target Details CBL Application Details References for anti-CBL Antibody (ABIN967970) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.

References for anti-CBL Antibody (ABIN967970)

Product Details anti-CBL Antibody Target Details CBL Application Details Handling Images back to top
Product cited in:

Jiang, Huang, Marusyk, Sorkin: "Grb2 regulates internalization of EGF receptors through clathrin-coated pits." in: Molecular biology of the cell, Vol. 14, Issue 3, pp. 858-70, 2003

Burke, Schooler, Wiley: "Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking." in: Molecular biology of the cell, Vol. 12, Issue 6, pp. 1897-910, 2001

Garcia, Miller: "Single-cell analyses reveal two defects in peptide-specific activation of naive T cells from aged mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 5, pp. 3151-7, 2001

Sanjay, Houghton, Neff, DiDomenico, Bardelay, Antoine, Levy, Gailit, Bowtell, Horne, Baron: "Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility." in: The Journal of cell biology, Vol. 152, Issue 1, pp. 181-95, 2001

Donovan, Wange, Langdon, Samelson: "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor." in: The Journal of biological chemistry, Vol. 269, Issue 37, pp. 22921-4, 1994

Images

Product Details anti-CBL Antibody Target Details CBL Application Details Handling References for anti-CBL Antibody (ABIN967970) back to top
Supplier Images
Western Blotting (WB) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (AA 595-810) (ABIN967970) Western blot analysis of c-Cbl on Jurkat lysate. Lane 1: 1:5000, lane 2: 1:10000, lan...
Immunofluorescence (IF) image for anti-CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (AA 595-810) (ABIN967970) Immunofluorescent staining of Rabbit Lung tissue with anti-c-cbl antibody.