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anti-Mouse (Murine) CD80 antibody for Functional Studies

Recommended CD80 Antibody (supplied by: Log in to see )

Antigen
CD80 Antibodies
  • B7
  • B7-1
  • B7.1
  • B71
  • BB1
  • CD8
  • Cd28l
  • CD28LG
  • CD28LG1
  • LAB7
  • Leu2
  • Ly-53
  • Ly53
  • MAL
  • MIC17
  • p32
  • TSA1
Reactivity
Dog (Canine), Mouse (Murine)
314
221
50
16
10
9
8
3
2
2
1
Host
Hamster
288
109
98
58
16
14
Clonality
Monoclonal
Conjugate
This CD80 antibody is un-conjugated
67
65
41
26
11
10
8
7
5
5
5
4
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)
365
173
114
105
48
44
24
22
21
18
14
7
7
7
7
5
5
4
3
2
2
2
1
1
1
1
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Catalog No. ABIN567985
$ 198.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008743882 ABIN316878 Func FACS IHC (fro) Rat IgG2a Log in to see RM80 2
0.0008743882 ABIN489934 Func FACS IHC (fro) IP Hamster IgG2 Log in to see 16-10A1 8
0.0008743882 ABIN371006 Func FACS IP Rat IgG2a Log in to see 1G10 6
0.0008743882 ABIN371007 Func FACS IP Rat IgG2a Log in to see 1G10 6
0.0008743882 ABIN282273 Func FACS Armenian Hamster IgG Log in to see 16-10A1
0.0008743882 ABIN2472617 Func IHC (fro) FACS Rat IgG2a Log in to see RM80 4
0.0008743882 ABIN280500 Func FACS IHC (fro) IP Armenian Hamster IgG Log in to see 16-10A1
0.0008743882 ABIN1967873 Func IHC (fro) FACS IP Hamster IgG2 Log in to see 16-10A1
0.0008743882 ABIN217761 Func FACS IHC (fro) Rat IgG2a Log in to see
0.0008743882 ABIN2567919 Func FACS Mouse IgG1 kappa Log in to see 2D10-4
0.0008743882 ABIN2567920 Func FACS Mouse IgG1 kappa Log in to see 2D10-4
0.0008743882 ABIN2567925 Func FACS IF IP IHC Hamster IgG Log in to see 16-10A1
0.0008743882 ABIN2567926 Func FACS IP IHC Hamster IgG Log in to see 16-10A1
0.0008743882 ABIN600886 Func IHC (fro) FACS IHC (p) Rat IgG2a Log in to see
0.0008743882 ABIN3200026 FACS Func IHC (fro) IP Armenian Hamster IgG2 Log in to see 16-10A1
0.0008743882 ABIN3037606 Func FACS IP IHC Hamster IgG2 Log in to see

Top referenced anti-CD80 antibody for Functional Studies

Similar anti-CD80 Antibodies

Application / Reactivity Mouse (Murine)
Blocking Antibody (Inhibition) 2 Antibodies
Blocking Reagent (BR) 6 Antibodies
Depletion (Dep) 2 Antibodies
Dot Blot (DB) 1 Antibodies
ELISA 21 Antibodies
ELISA (Capture) 4 Antibodies
ELISpot (Capture) (ELISPOT (Capture)) 2 Antibodies
Enzyme Immunoassay (EIA) 5 Antibodies
Flow Cytometry (FACS) 170 Antibodies
Functional Studies (Func) 17 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 8 Antibodies
Immunofluorescence (IF) 6 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 25 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 4 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 17 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 6 Antibodies
Immunoprecipitation (IP) 52 Antibodies

General

Antigen CD80 Antibodies
Reactivity Dog (Canine), Mouse (Murine)
(314), (221), (50), (16), (10), (9), (8), (3), (2), (2), (1)
Host Hamster
(288), (109), (98), (58), (16), (14)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD80 antibody is un-conjugated
(67), (65), (41), (26), (11), (10), (8), (7), (5), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)
(365), (173), (114), (105), (48), (44), (24), (22), (21), (18), (14), (7), (7), (7), (7), (5), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1)
Pubmed 9 references available
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Product Details anti-CD80 Antibody

Target Details CD80 Application Details Handling References for anti-CD80 Antibody (ABIN567985) Images
Specificity This Hamster antibody reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
Cross-Reactivity (Details) Species reactivity (tested):Mouse, Canine (Dog).
Purification Protein-A affinity chromatography
Immunogen CD80-transfected CHO cell line
Clone 16-10A1
Isotype IgG2

Target Details CD80

Product Details anti-CD80 Antibody Application Details Handling References for anti-CD80 Antibody (ABIN567985) Images back to top
Antigen
Alternative Name CD80 (CD80 Antibody Abstract)
Background CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 Molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet, there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.Synonyms: Activation B7-1 antigen, B7-1, B7.1, BB1, CD28LG, CD28LG1, CTLA-4 counter-receptor B7.1, LAB7, T-lymphocyte activation antigen CD80
Gene ID 12519
NCBI Accession NP_033985
UniProt Q00609
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-CD80 Antibody Target Details CD80 Handling References for anti-CD80 Antibody (ABIN567985) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-CD80 Antibody Target Details CD80 Application Details References for anti-CD80 Antibody (ABIN567985) Images back to top
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS), pH ~7.4 with 15 mM Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

References for anti-CD80 Antibody (ABIN567985)

Product Details anti-CD80 Antibody Target Details CD80 Application Details Handling Images back to top
Background publications

Ghann, Aras, Fleiter, Daniel: "Syntheses and characterization of lisinopril-coated gold nanoparticles as highly stable targeted CT contrast agents in cardiovascular diseases." in: Langmuir : the ACS journal of surfaces and colloids, Vol. 28, Issue 28, pp. 10398-408, 2012

Gueirard, Ave, Balazuc, Thiberge, Huerre, Milon, Guiso: "Bordetella bronchiseptica persists in the nasal cavities of mice and triggers early delivery of dendritic cells in the lymph nodes draining the lower and upper respiratory tract." in: Infection and immunity, Vol. 71, Issue 7, pp. 4137-43, 2003

Product cited in:

Mukherjee, Ahmed, Malu, Nandi: "Modulation of cell cycle progression by CTLA4-CD80/CD86 interactions on CD4+ T cells depends on strength of the CD3 signal: critical role for IL-2." in: Journal of leukocyte biology, Vol. 80, Issue 1, pp. 66-74, 2006

Odobasic, Kitching, Semple, Timoshanko, Tipping, Holdsworth: "Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis." in: Journal of the American Society of Nephrology : JASN, Vol. 16, Issue 7, pp. 2012-22, 2005

Paust, Lu, McCarty, Cantor: "Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 28, pp. 10398-403, 2004

Reiser, von Gersdorff, Loos, Oh, Asanuma, Giardino, Rastaldi, Calvaresi, Watanabe, Schwarz, Faul, Kretzler, Davidson, Sugimoto, Kalluri, Sharpe, Kreidberg, Mundel: "Induction of B7-1 in podocytes is associated with nephrotic syndrome." in: The Journal of clinical investigation, Vol. 113, Issue 10, pp. 1390-7, 2004

Quah, Ni, ONeill: "In vitro hematopoiesis produces a distinct class of immature dendritic cells from spleen progenitors with limited T cell stimulation capacity." in: International immunology, Vol. 16, Issue 4, pp. 567-77, 2004

Mencacci, Montagnoli, Bacci, Cenci, Pitzurra, Spreca, Kopf, Sharpe, Romani: "CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 6, pp. 3180-90, 2002

Horspool, Perrin, Woodcock, Cox, King, June, Harlan, St Louis, Lee: "Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 6, pp. 2706-14, 1998