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Browse our Cytoplasmic Protein NCK1 Proteins (NCK1)

Full name:
NCK Adaptor Protein 1 Proteins (NCK1)
On www.antibodies-online.com are 14 NCK Adaptor Protein 1 (NCK1) Proteins from 5 different suppliers available. Additionally we are shipping Cytoplasmic Protein NCK1 Antibodies (119) and many more products for this protein. A total of 140 Cytoplasmic Protein NCK1 products are currently listed.
Synonyms:
6330586M15Rik, D230010O13Rik, Nck, Nck-1, NCK1, NCKalpha
list all proteins Gene Name GeneID UniProt
NCK1 4690 P16333
Rat NCK1 NCK1 300955  
NCK1 17973 Q99M51

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Cytoplasmic Protein NCK1 Proteins (NCK1) by Origin

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Top referenced Cytoplasmic Protein NCK1 Proteins

  1. Human Cytoplasmic Protein NCK1 Protein expressed in Escherichia coli (E. coli) - ABIN667017 : Chen, She, Davis, Spicer, Kim, Ren, Le Beau, Li: Identification of Nck family genes, chromosomal localization, expression, and signaling specificity. in The Journal of biological chemistry 1998 (PubMed)
    Show all 2 references for ABIN667017

  2. Human Cytoplasmic Protein NCK1 Protein expressed in Mouse - ABIN1774727 : Borroto, Arellano, Dopfer, Prouza, Suchànek, Fuentes, Orfao, Schamel, Alarcón: Nck recruitment to the TCR required for ZAP70 activation during thymic development. in Journal of immunology (Baltimore, Md. : 1950) 2013 (PubMed)

More Proteins for Cytoplasmic Protein NCK1 Interaction Partners

Human NCK Adaptor Protein 1 (NCK1) interaction partners

  1. Results demonstrate that Nck acts as an important hub integrating angiogenic cues with cytoskeletal changes that enable endothelial apical-basal polarization and lumen formation.

  2. the binding of Nck to the TCR requires partial phosphorylation of CD3epsilon (show CD3E Proteins), as it is based on two cooperating interactions.

  3. Nck was the most potent activator of N-WASP-driven actin assembly.

  4. TSAD (show SH2D2A Proteins) binds to and co-localizes with Nck. Expression of TSAD (show SH2D2A Proteins) increases both Nck-Lck (show LCK Proteins) and Nck-SLP-76 (show LCP2 Proteins) interaction in T cells.

  5. these data identify Nck as an important mediator of oxidative stress-induced (show SQSTM1 Proteins) inflammation and a potential therapeutic target for ischemia/reperfusion injury.

  6. Nck1 depletion induces activation of the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway by attenuating PTP1B (show PTPN1 Proteins) protein expression

  7. Tir-Intimin interaction recruits the Nck adaptor to a Tir tyrosine phosphorylated residue where it activates neural Wiskott-Aldrich syndrome protein (N-WASP (show WASL Proteins)).

  8. biochemical reconstitution on supported lipid bilayers of protein clusters containing the adhesion receptor Nephrin (show NPHS1 Proteins) and its cytoplasmic partners, Nck and N-WASP (show WASL Proteins), is reported.

  9. SDF1alpha-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells.

  10. These results identify a new domain of CE that is specific to its function in cytoplasmic capping, and a new role for Nck1 in regulating gene expression through its role as the scaffold for assembly of the cytoplasmic capping complex.

Mouse (Murine) NCK Adaptor Protein 1 (NCK1) interaction partners

  1. Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses.

  2. In mice with Nck1/2 deletions, endothelial cells fail to develop front-rear polarized vessel sprouts.

  3. These results reveal that Nck regulates preosteoblastic/osteoblastic migration and bone mass.

  4. we show that the non-catalytic region of tyrosine kinase adaptor (NCK) proteins 1 and 2 are distributed in the developing spinal cord

  5. Nck proteins not only participate in thymic selection and generation of the peripheral T cell repertoire but also are involved in the differentiation and effector functions of CD4 (show CD4 Proteins)(+) T cells.

  6. these data identify Nck as an important mediator of oxidative stress-induced (show SQSTM1 Proteins) inflammation and a potential therapeutic target for ischemia/reperfusion injury.

  7. Nck may function as an effector of T-cell receptor conformational changes during T cell development.

  8. Mouse embryos lacking endothelial Nck1/2 expression develop extensive angiogenic defects that result in lethality at about embryonic day 10.

  9. Nck1 negatively regulates PERK (show EIF2AK3 Proteins) by interacting with PERK (show EIF2AK3 Proteins) and protecting PERK (show EIF2AK3 Proteins) from being dephosphorylated at its inhibitory site pY(561) and in this way affects pancreatic beta-cell proinsulin (show INS Proteins) biogenesis.

  10. that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3epsilon (show CD3E Proteins) interaction may represent a target for pharmacological modulation of the immune response.

Cytoplasmic Protein NCK1 (NCK1) Protein Profile

Protein Summary

The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.

Alternative names and synonyms associated with Cytoplasmic Protein NCK1 (NCK1)

  • NCK adaptor protein 1 (NCK1)
  • NCK adaptor protein 1 (LOC100347965)
  • NCK adaptor protein 1 (LOC100358703)
  • NCK adaptor protein 1 (Nck1)
  • non-catalytic region of tyrosine kinase adaptor protein 1 (Nck1)
  • 6330586M15Rik protein
  • D230010O13Rik protein
  • Nck protein
  • Nck-1 protein
  • NCK1 protein
  • NCKalpha protein

Protein level used designations for NCK Adaptor Protein 1 Proteins (NCK1)

cytoplasmic protein NCK1 , NCK adaptor protein 1 , cytoplasmic protein NCK1-like , NCK tyrosine kinase , SH2/SH3 adaptor protein NCK-alpha , melanoma NCK protein , non-catalytic region of tyrosine kinase , non-catalytic region of tyrosine kinase adaptor protein 1

GENE ID SPECIES
460720 Pan troglodytes
485677 Canis lupus familiaris
536154 Bos taurus
716807 Macaca mulatta
100016740 Monodelphis domestica
100171550 Pongo abelii
100192438 Sus scrofa
100307045 Ovis aries
100347965 Oryctolagus cuniculus
100358703 Oryctolagus cuniculus
100471786 Ailuropoda melanoleuca
100603655 Nomascus leucogenys
4690 Homo sapiens
300955 Rattus norvegicus
17973 Mus musculus
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