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PKCepsilon is a key upstream mediator in resistin (show RETN Proteins)-induced inflammation that may interact synergistically with TLR4 (show TLR4 Proteins) to promote NF-kB activation in macrophages.
protein kinase C-epsilon regulation, phospholipase D1 protects retinal pigment epithelium cells from lipopolysaccharide-induced damage
PKCdelta (show PKCd Proteins) and PKCepsilon work as a functional couple with opposite roles on thrombopoiesis, and the modulation of their balance strongly impacts platelet production.
Curcumin inhibited phorbol ester-induced membrane translocation of protein kinase C-epsilon (PKCepsilon) mutants, in which the epsilonC1 domain was replaced with alphaC1, but not the protein kinase C-alpha (PKCalpha (show PKCa Proteins)) mutant in which alphaC1 was replaced with the epsilonC1 domain, suggesting that alphaC1 is a determinant for curcumin's inhibitory effect.
we demonstrate that PKCepsilon cooperates with the loss of the tumor suppressor Pten for the development of prostate cancer in a mouse model. Mechanistic analysis revealed that PKCe overexpression and Pten loss individually and synergistically upregulate the production of the chemokine (show CCL1 Proteins) CXCL13 (show CXCL13 Proteins), which involves the transcriptional activation of the CXCL13 (show CXCL13 Proteins) gene
These results indicate that PKC (show PRRT2 Proteins) promotes synaptogenesis by activating PSD-95 (show DLG4 Proteins) phosphorylation directly through JNK1 (show MAPK8 Proteins) and calcium/calmodulin-dependent kinase II and also by inducing expression of PSD-95 (show DLG4 Proteins) and synaptophysin (show SYP Proteins).
epsilonPKC phosphorylation and its coevolution with ALDH2 (show ALDH2 Proteins) play an important role in the regulation and protection of ALDH2 (show ALDH2 Proteins) enzyme activity.
PKCepsilon down-regulation suppresses sorting and the cancer stem-like phenotype of renal cell carcinoma (show MOK Proteins) 769P side population cells through the regulation of ABCB1 (show ABCB1 Proteins) transporter and the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins), Stat3 (show STAT3 Proteins) and MAPK/ERK (show MAPK1 Proteins) pathways that are dependent on the phosphorylation effects.
PRKCE plays two major roles in cardiac muscle cells: it takes part in regulating cardiac muscle contraction via targeting the sarcomeric proteins, as well as it modulates cardiac cell energy production and metabolism by targeting cardiac mitochondria. (Review)
PKCepsilon is a key factor for driving the formation of bone metastasis by prostate cancer cells and is a potential therapeutic target for advanced stages of the disease.
PKCepsilon is a negative regulator of megakaryopoiesis
study establishes that the pseudosubstrate of PKC-epsilon binds phosphatidylinositol 4-phosphate (PI4P), tethering it to the trans-Golgi network (TGN (show TG Proteins)). This TGN (show TG Proteins)-associated pool of PKC-epsilon is necessary for its concentration at the phagocytic cup and Fc [gamma] receptor (FcgammaR)-dependent membrane fusion
that PKC-epsilon activation mediates 1) dysfunction of complexes I and III of the respiratory chain, 2) oxidant production, 3) morphological damage to the kidney, and 4) decreases in renal functions after ischemia
Sstudy provides evidence that PKCepsilon-ALDH2 (show ALDH2 Proteins) pathway positively regulates adipocyte differentiation by regulation of PPARgamma (show PPARG Proteins) transcriptional activity.
Data suggest that PKCe positively regulates beta-catenin (show CTNNB1 Proteins) expression and stabilization in a glycogen synthase kinase 3beta-independent manner; beta-catenin (show CTNNB1 Proteins) exhibits a perinuclear localization pattern in podocytes; however, beta-catenin (show CTNNB1 Proteins) is predominantly localized to nucleus in podocytes from PKCe knockout mice. (PKCe = protein kinase C epsilon)
Results demonstrate that specific inhibition of PKCepsilon reduces ethanol consumption and prolongs ethanol intoxication, support the development of inhibitors of PKCepsilon catalytic activity as a strategy to reduce ethanol consumption, and they demonstrate that the AS- PKCepsilon mouse is a useful tool to study the role of PKCepsilon in behavior.
inhibition of mu-opioid receptor expression blocks morphine and DAMGO increases in the translocation of NF-kB p65 protein in microglia.a low dose of morphine, exerting its effects via the mu-opioid receptor, increases the DNA-binding activity of NF-kB via PKCepsilon, while a high dose of morphine triggers a nonopiate receptor response mediated by TLR4 and, interestingly, PKC signalling
PKCepsilon signaling in both the nucleus accumbens and central nucleus of the amygdala is a major contributor to binge alcohol drinking and to the genetic propensity to consume excessive amounts of alcohol.
with strain there was significant PKCepsilon translocation to the Z-disc and co-localization with CapZbeta1 or alpha-actinin (show ACTN1 Proteins), which was quantified on confocal images.
Protein kinase C epsilon phosphorylates the alpha4 nAChR (show CHRNA4 Proteins) subunit and regulates recovery from receptor desensitization.
These data identify PKCepsilon as a key regulator of cilia slowing in response to combined smoke and alcohol-induced lung injury.
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS (show NOS3 Proteins) post-translational modification
Differential expression of protein kinase C epsilon and an elevation of [Ca(2 (show CA2 Proteins)+)]i are important for acquisition of luteolytic response to PGF2 alpha
By regulating VEGFR2 (show KDR Proteins) expression and activation, PKC-epsilon expression is critical for activation of Akt (show AKT1 Proteins) and eNOS (show NOS3 Proteins) by VEGF (show VEGFA Proteins) and contributes to VEGF (show VEGFA Proteins)-stimulated Erk (show MAPK1 Proteins) activation, whereas PKC-alpha (show PKCa Proteins) has opposite effects.
Activation of PKC induces the translocation of Nrf2 (show NFE2L2 Proteins) and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
in contrast to protective effects of PKC-epsilon activation in cardiomyocytes, sustained PKC-epsilon activation is detrimental to mitochondrial function and viability in renal proximal tubule cells
Preferential glucose utilization by PKCepsilon hearts is orchestrated by a p-GSK3beta/HIF-1alpha (show HIF1A Proteins)-mediated mechanism.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.
protein kinase C epsilon type
, protein kinase C, epsilon
, protein kinase C epsilon type-like
, pkc epsilon
, protein kinase C, eta