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Human STIM1 Protein expressed in Wheat germ - ABIN1321631
Hawkins, Irrinki, Mallilankaraman, Lien, Wang, Bhanumathy, Subbiah, Ritchie, Soboloff, Baba, Kurosaki, Joseph, Gill, Madesh: S-glutathionylation activates STIM1 and alters mitochondrial homeostasis. in The Journal of cell biology 2010
Downregulation of STIM1 levels in oocytes by siRNA completely inhibited the repetitive Ca(2 (show CA2 Proteins)+) signal triggered by the fertilizing sperm.
findings suggest that in oocytes, STIM1 serves as a sensor of Ca(2 (show CA2 Proteins)+) store content that after store depletion moves to the plasma membrane to stimulate store-operated Ca(2 (show CA2 Proteins)+) entry
STIM1 plays role in PAR1 (show F2R Proteins)-mediated Ca2 (show CA2 Proteins)+ influx and Ca2 (show CA2 Proteins)+-dependent NO production in endothelial cells; DNA sequence alignment of porcine and human STIM1
STIM1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
STIM1/TRPC1 (show TRPC1 Proteins)-dependent store-operated Ca2 (show CA2 Proteins)+ entry plays an essential role in generating spatiotemporal Ca2 (show CA2 Proteins)+ signals that mediate guidance responses of nerve growth cones.
STIM1 and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production.
These findings suggest that the surface location of SARAF (show TMEM66 Proteins) is dependent on the expression of STIM1 in the plasma membrane.
sp(2) -Iminosugar alpha-glucosidase (show AGLU Proteins) inhibitor 1 (show PPP1R1A Proteins)-C-octyl-2-oxa-3-oxocastanospermine inhibits breast cancer cell migration via beta1-integrin, Stim1, and FAK (show PTK2 Proteins) signaling pathways.
The STIM1 protein play important roles in TGF-beta (show TGFB1 Proteins)-induced EMT (show ITK Proteins) and these effects are related to both store-operated calcium entry and non-store-operated calcium entry.
STIM1-dependent control of Ca2 (show CA2 Proteins)+ clearance regulates NFAT (show NFATC1 Proteins) activity during T-cell activation
RASSF4 (show RIN2 Proteins) controls store operated calcium entry and endoplasmic reticulum-plasma membrane junctions through ARF6 (show ARF6 Proteins)-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological processes.
conformational changes in STIM1 upon calcium release
STIM1-induced Ca(2 (show CA2 Proteins)+) signaling activates Pyk2 (show PTK2B Proteins) to inhibit the interaction of VE-PTP (show PTPRB Proteins) and VE-cadherin (show CDH5 Proteins) and hence increase endothelial permeability.
Elevated Orai1 and STIM1 expressions upregulate MACC1 (show MACC1 Proteins) expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer.
It represents as a target of cisplatin and blockade of Stim1-mediated Ca(2 (show CA2 Proteins)+) entry may be a useful strategy to improve the efficacy of cisplatin to treat osteosarcoma.
STIM1L and TRPC1 (show TRPC1 Proteins)/4 are working together in myotubes to ensure efficient store refilling and a proper differentiation program.
STIM1 and STIM2 (show Stim2 Proteins) are expressed in bovine aortic endothelial cells and they both interact with IP3R-1 (show ITPR1 Proteins).
Reactive oxygen species (ROS (show ROS1 Proteins)) production, degranulation, and phagocytosis are normal in the absence of STIM2 (show Stim2 Proteins), suggesting STIM1 is the dominant calcium sensor required for classical short-term neutrophil responses
Stromal interaction molecule 1 (STIM1), which regulates the refilling of ER Ca(2 (show CA2 Proteins)+), has been investigated in several systems including the CNS. In addition to a previous study showing that STIM1 regulates dendritic ER Ca(2 (show CA2 Proteins)+) refilling and mGluR1 (show GRM1 Proteins)-mediated synaptic transmission, we provide compelling evidence describing a novel role of STIM1 in spike firing Purkinje neurons.
data indicate that STIM1 overexpression in neurons in the brain perturbs metabotropic glutamate (show GRIN1 Proteins) receptor signaling, leading to impairments in long-term depression and alterations in animal behavior
Ca(2 (show CA2 Proteins)+) entry serves critical cellular functions in virtually every cell type, and appropriate regulation of Ca(2 (show CA2 Proteins)+) in neurons is essential for proper function.
suggests that STIM1 is a multifunctional signaling effector that participates in the control of membrane excitability and Ca(2 (show CA2 Proteins)+) signaling events in beta-cells
vascular smooth muscle STIM1 plays a crucial role in the development of hypertension and associated cardiovascular pathologies.
Data show that the STIM1 Ksp (Eg5 (show KIF11 Proteins))-cre knockout mice produced more urine compared to control.
We conclude that STIM1 has an unexpected function in the heart where it alters communication between the sarcolemma and sarcoplasmic reticulum resulting in greater Ca(2 (show CA2 Proteins)+) flux and a leaky SR compartment.
Stim1 silencing prevented mTOR complex 2 phosphorylation of Akt(S473) via a direct interaction between STIM1 and Rictor. This represses GSK-3beta activity and prevents/reverses cardiac hypertrophy.
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
stromal interaction molecule 1
, stromal interaction molecule 1b