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anti-Mammalian TGFB1 antibody for Flow Cytometry

Recommended TGFB1 Antibody (supplied by: Log in to see )

Antigen
Transforming Growth Factor, beta 1 (TGFB1) Antibodies
  • ai39657
  • betaig-h3
  • bigh3
  • cdb1
  • cdg2
  • cdgg1
  • CED
  • ced
  • csd
  • csd1
  • csd2
  • csd3
  • DPD1
  • dpd1
  • ebmd
  • LAP
  • lap
  • lcd1
  • MGC146225
  • tgf
  • TGF-beta
  • tgf-beta
  • TGF-BETA-1
  • TGF-beta1
  • TGF-beta5
  • TGFB
  • Tgfb
  • tgfb
  • Tgfb-1
  • tgfb1
  • TGFB1
  • TGFB4
  • tgfb5
  • TGFbeta
  • tgfbeta
  • TGFbeta1
  • TGFBI
  • wu:fb13a07
  • xx:ai39657
Reactivity
Mammalian
255
75
63
24
13
13
11
10
7
6
4
3
3
3
2
1
1
Host
Mouse
230
101
4
3
3
2
1
Clonality
Monoclonal
Conjugate
This TGFB1 antibody is un-conjugated
32
23
11
9
8
3
3
3
3
3
3
3
3
3
3
1
1
1
Application
Flow Cytometry (FACS)
201
190
98
40
38
33
31
26
18
12
11
4
3
2
2
2
2
2
1
1
Supplier
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Catalog No. ABIN2665500
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Top referenced anti-TGFB1 antibody for Flow Cytometry

Similar anti-TGFB1 Antibodies

Application / Reactivity Mammalian
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Flow Cytometry (FACS) 1 Antibodies
Immunofluorescence (IF) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 2 Antibodies
Western Blotting (WB) 2 Antibodies

General

Antigen Transforming Growth Factor, beta 1 (TGFB1) Antibodies
Reactivity Mammalian
(255), (75), (63), (24), (13), (13), (11), (10), (7), (6), (4), (3), (3), (3), (2), (1), (1)
Host Mouse
(230), (101), (4), (3), (3), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TGFB1 antibody is un-conjugated
(32), (23), (11), (9), (8), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application Flow Cytometry (FACS)
(201), (190), (98), (40), (38), (33), (31), (26), (18), (12), (11), (4), (3), (2), (2), (2), (2), (2), (1), (1)
Pubmed 13 references available
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Product Details anti-TGFB1 Antibody

Target Details TGFB1 Application Details Handling References for anti-TGFB1 Antibody (ABIN2665500) Images
Purification The antibody was purified by antigen-affinity chromatography.
Clone 21C11
Isotype IgG2a

Target Details TGFB1

Product Details anti-TGFB1 Antibody Application Details Handling References for anti-TGFB1 Antibody (ABIN2665500) Images back to top
Antigen
Alternative Name TGF-Beta1 (TGFB1 Antibody Abstract)
Background Transforming growth factor beta 1 (TGF-β1) is a member of the transforming growth factor beta superfamily of cytokines. The TGF-β1 precursor contains 390 amino acids with an N-terminal signal peptide of 29 amino acids required for secretion from a cell, a 249 amino acid pro-region (latency associated peptide or LAP), and a 112 amino acid C-terminal region that becomes the active TGF-β1 upon activation. Both LAP and TGF-β1 exist as homodimers in circulation, but the disulfide linked homodimers of LAP and TGF-β1 remain non-covalently associated, forming the small latent TGF-β complex (SLC, 100 kD). The large latent TGF-β complex (LLC, 235-260 kD) contains a third component, the latent TGF-β binding protein (LTBP), which is linked to LAP by a single disulfide bond. LTBP does not confer latency but is for efficient secretion of the complex to extracellular sites. Free active TGF-β1 can be released (activated) by many factors, including enzymes and low or high pH . TGF-β1 is nearly 100 % conserved across mammalian species. It has diverse biological functions in multiple cellular processes such as regulating proliferation and differentiation of various cell types. TGF-β1 is also an important immunoregulatory cytokine, which is involved in the maintenance of self-tolerance, Th17 differentiation, and T-cell homeostasis.
Pathways TCR Signaling, ACE Inhibitor Pathway, EGFR Signaling Pathway

Application Details

Product Details anti-TGFB1 Antibody Target Details TGFB1 Handling References for anti-TGFB1 Antibody (ABIN2665500) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TGFB1 Antibody Target Details TGFB1 Application Details References for anti-TGFB1 Antibody (ABIN2665500) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-TGFB1 Antibody (ABIN2665500)

Product Details anti-TGFB1 Antibody Target Details TGFB1 Application Details Handling Images back to top
Background publications

Oida, Weiner: "Murine CD4 T cells produce a new form of TGF-β as measured by a newly developed TGF-β bioassay." in: PLoS ONE, Vol. 6, Issue 4, pp. e18365, 2011

Takatori, Kanno, Chen, OShea: "New complexities in helper T cell fate determination and the implications for autoimmune diseases." in: Modern rheumatology / the Japan Rheumatism Association, Vol. 18, Issue 6, pp. 533-41, 2008

Manel, Unutmaz, Littman: "The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat." in: Nature immunology, Vol. 9, Issue 6, pp. 641-9, 2008

Veldhoen, Uyttenhove, van Snick, Helmby, Westendorf, Buer, Martin, Wilhelm, Stockinger: "Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset." in: Nature immunology, Vol. 9, Issue 12, pp. 1341-6, 2008

Acosta-Rodriguez, Napolitani, Lanzavecchia, Sallusto: "Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells." in: Nature immunology, Vol. 8, Issue 9, pp. 942-9, 2007

Mucida, Park, Kim, Turovskaya, Scott, Kronenberg, Cheroutre: "Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid." in: Science (New York, N.Y.), Vol. 317, Issue 5835, pp. 256-60, 2007

Puthawala, Hadjiangelis, Jacoby, Bayongan, Zhao, Yang, Devitt, Horan, Weinreb, Lukashev, Violette, Grant, Colarossi, Formenti, Munger: "Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis." in: American journal of respiratory and critical care medicine, Vol. 177, Issue 1, pp. 82-90, 2007

Park: "Fine tuning and cross-talking of TGF-beta signal by inhibitory Smads." in: Journal of biochemistry and molecular biology, Vol. 38, Issue 1, pp. 9-16, 2005

Valcourt, Kowanetz, Niimi, Heldin, Moustakas: "TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition." in: Molecular biology of the cell, Vol. 16, Issue 4, pp. 1987-2002, 2005

Zou, Sun: "Overexpression of human transforming growth factor-beta1 using a recombinant CHO cell expression system." in: Protein expression and purification, Vol. 37, Issue 2, pp. 265-72, 2004

Annes, Munger, Rifkin: "Making sense of latent TGFbeta activation." in: Journal of cell science, Vol. 116, Issue Pt 2, pp. 217-24, 2002

Dennler, Itoh, Vivien, ten Dijke, Huet, Gauthier: "Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene." in: The EMBO journal, Vol. 17, Issue 11, pp. 3091-100, 1998

Dubois, Laprise, Blanchette, Gentry, Leduc: "Processing of transforming growth factor beta 1 precursor by human furin convertase." in: The Journal of biological chemistry, Vol. 270, Issue 18, pp. 10618-24, 1995

Images

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Supplier Images
ELISA image for anti-TGFB1 antibody (Transforming Growth Factor, beta 1) (ABIN2665500) anti-Transforming Growth Factor, beta 1 (TGFB1) antibody