|Antigen||Transforming Growth Factor, beta 1 (TGFB1) Antibodies|
|Conjugate||This TGFB1 antibody is un-conjugated Alternatives|
Flow Cytometry (FACS)
|13 references available|
|Supplier||Log in to see|
Product Details anti-TGFB1 AntibodyTarget Details TGFB1 Application Details Handling References for anti-TGFB1 Antibody (ABIN2665500) Images
|Purification||The antibody was purified by antigen-affinity chromatography.|
Target Details TGFB1Product Details anti-TGFB1 Antibody Application Details Handling References for anti-TGFB1 Antibody (ABIN2665500) Images back to top
|Alternative Name||TGF-Beta1 (TGFB1 Antibody Abstract)|
|Background||Transforming growth factor beta 1 (TGF-β1) is a member of the transforming growth factor beta superfamily of cytokines. The TGF-β1 precursor contains 390 amino acids with an N-terminal signal peptide of 29 amino acids required for secretion from a cell, a 249 amino acid pro-region (latency associated peptide or LAP), and a 112 amino acid C-terminal region that becomes the active TGF-β1 upon activation. Both LAP and TGF-β1 exist as homodimers in circulation, but the disulfide linked homodimers of LAP and TGF-β1 remain non-covalently associated, forming the small latent TGF-β complex (SLC, 100 kD). The large latent TGF-β complex (LLC, 235-260 kD) contains a third component, the latent TGF-β binding protein (LTBP), which is linked to LAP by a single disulfide bond. LTBP does not confer latency but is for efficient secretion of the complex to extracellular sites. Free active TGF-β1 can be released (activated) by many factors, including enzymes and low or high pH . TGF-β1 is nearly 100 % conserved across mammalian species. It has diverse biological functions in multiple cellular processes such as regulating proliferation and differentiation of various cell types. TGF-β1 is also an important immunoregulatory cytokine, which is involved in the maintenance of self-tolerance, Th17 differentiation, and T-cell homeostasis.|
|Pathways||TCR Signaling, ACE Inhibitor Pathway, EGFR Signaling Pathway|
Application DetailsProduct Details anti-TGFB1 Antibody Target Details TGFB1 Handling References for anti-TGFB1 Antibody (ABIN2665500) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TGFB1 Antibody Target Details TGFB1 Application Details References for anti-TGFB1 Antibody (ABIN2665500) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-TGFB1 Antibody (ABIN2665500)Product Details anti-TGFB1 Antibody Target Details TGFB1 Application Details Handling Images back to top
Oida, Weiner: "Murine CD4 T cells produce a new form of TGF-β as measured by a newly developed TGF-β bioassay." in: PLoS ONE, Vol. 6, Issue 4, pp. e18365, 2011 (PubMed).
Veldhoen, Uyttenhove, van Snick et al.: "Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset." in: Nature immunology, Vol. 9, Issue 12, pp. 1341-6, 2008 (PubMed).
Takatori, Kanno, Chen et al.: "New complexities in helper T cell fate determination and the implications for autoimmune diseases." in: Modern rheumatology / the Japan Rheumatism Association, Vol. 18, Issue 6, pp. 533-41, 2008 (PubMed).
Manel, Unutmaz, Littman: "The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat." in: Nature immunology, Vol. 9, Issue 6, pp. 641-9, 2008 (PubMed).
Puthawala, Hadjiangelis, Jacoby et al.: "Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis." in: American journal of respiratory and critical care medicine, Vol. 177, Issue 1, pp. 82-90, 2007 (PubMed).
Acosta-Rodriguez, Napolitani, Lanzavecchia et al.: "Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells." in: Nature immunology, Vol. 8, Issue 9, pp. 942-9, 2007 (PubMed).
Mucida, Park, Kim et al.: "Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid." in: Science (New York, N.Y.), Vol. 317, Issue 5835, pp. 256-60, 2007 (PubMed).
Park: "Fine tuning and cross-talking of TGF-beta signal by inhibitory Smads." in: Journal of biochemistry and molecular biology, Vol. 38, Issue 1, pp. 9-16, 2005 (PubMed).
Valcourt, Kowanetz, Niimi et al.: "TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition." in: Molecular biology of the cell, Vol. 16, Issue 4, pp. 1987-2002, 2005 (PubMed).
Zou, Sun: "Overexpression of human transforming growth factor-beta1 using a recombinant CHO cell expression system." in: Protein expression and purification, Vol. 37, Issue 2, pp. 265-72, 2004 (PubMed).
Annes, Munger, Rifkin: "Making sense of latent TGFbeta activation." in: Journal of cell science, Vol. 116, Issue Pt 2, pp. 217-24, 2002 (PubMed).
Dennler, Itoh, Vivien et al.: "Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene." in: The EMBO journal, Vol. 17, Issue 11, pp. 3091-100, 1998 (PubMed).
Dubois, Laprise, Blanchette et al.: "Processing of transforming growth factor beta 1 precursor by human furin convertase." in: The Journal of biological chemistry, Vol. 270, Issue 18, pp. 10618-24, 1995 (PubMed).
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