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The AtLIG1 is an important component of the active DNA demethylation machinery.
LIG1 is required for both single-nucleotide or long-patch base excision repair.
In the study, we show that loss-of-function of the major DNA LIGASE I (AtLIG1) in Arabidopsis thaliana causes maternal effects in the endosperm, which is the seed tissue that nurtures embryo development.
Nuclear or mitochondrial targeting of LIG1 is accomplished through an evolutionarily conserved translation initiation mechanism. [AtLIG1]
DNA ligase 1 functions in both DNA replication and in repair of both ss and dsDNA strand breaks.
Data suggest that DNA ligase I (LigI)-deficient 46BR.1G1 cells represent a model to investigate the biological effects of sub-lethal levels of DNA insults.
The LIG1 CC genotype was associated with susceptibility to non-small cell lung cancer, and the AA genotype demonstrated increased radiosensitivity compared to the AC and CC genotypes.
Ppolymorphisms in LIG1 affect its expression and may therefore change its function.
there is no association between LIGI polymorphisms and cervical cancer risk. However, they may be playing an important role in modulating the risk of cervical adenocarcinoma in North Indian women
DNA ligase I also interacts with replication factor C, the factor that loads the PCNA (show PCNA Proteins) trimeric ring onto DNA.
Data indicate that Ku70 (show XRCC6 Proteins)/Ku80 (show XRCC5 Proteins) facilitates the cooperative binding of multiple XRCC4 (show XRCC4 Proteins)/Ligase IV (XL) and XLF (show NHEJ1 Proteins) molecules to DNA.
Single nucleotide polymorphisms in LIG1 are associated with myelodysplastic syndromes.
phosphorylation of serine 51 on hLigI plays a critical role in regulating the interaction between hLigI and RFC (show RFC1 Proteins), which is required for efficient DNA replication and repair.
Data show that association of study-wide significance (P < 8.2 x 10(-5)) was identified for single-nucleotide polymorphisms (SNP) in TP53 (show TP53 Proteins), LIG1, and BIK (show BIK Proteins).
Kinetic mechanism of human DNA ligase I reveals magnesium-dependent changes in the rate-limiting step that compromise ligation efficiency.
Lig1 (show Lrig1 Proteins) is not absolutely required for cellular DNA replication and repair in Lig1 (show Lrig1 Proteins)-null cell line.
LigI has a highly specific role in CTG repeat maintenance in the maternal germline, involved in mediating CTG expansions and in the avoidance of maternal CTG contractions.
DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.
LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.
DNA ligase 1
, polydeoxyribonucleotide synthase [ATP] 1
, DNA ligase (ATP) 1
, DNA ligase I
, LIG1, ligase I, DNA, ATP-dependent