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Browse our Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Proteins (POLD1)

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Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Proteins (POLD1)
On www.antibodies-online.com are 3 Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) Proteins from 2 different suppliers available. Additionally we are shipping Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Antibodies (40) and Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Kits (1) and many more products for this protein. A total of 46 Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa products are currently listed.
Synonyms:
125kDa, 5949, CAA61369, CDC2, CG5949, CRCS10, Dmel\\CG5949, Dm Poldelta, dnapol delta, DNA Pol Delta, l(3)72Ac, POLD, POLD3, Poldelta, Pol delta
list all proteins Gene Name GeneID UniProt
POLD1 5424 P28340
POLD1 18971 P52431
Rat POLD1 POLD1 59294 O54747

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Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Proteins (POLD1) by Origin

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More Proteins for Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Interaction Partners

Fruit Fly (Drosophila melanogaster) Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) interaction partners

  1. in Drosophila the alternative TRF1/BRF complex appears responsible for the initiation of all known classes of Pol III transcription

Human Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) interaction partners

  1. Mutations in POLE and POLD1 in south east Asia women with grade 3 endometrioid endometrial carcinomas are associated with improved recurrence free survival.

  2. POLD1 germline mutations can result in a variably expressed and probably underdiagnosed segmental progeroid syndrome.

  3. None of the 1188 patients carried the POLD1 p.(Ser478Asn) variant. POLE germline variant carriers are also associated with a microsatellite instable colorectal cancer

  4. POLD1 plays important role in the regulation of cell cycle progression and DNA damage repair

  5. analysis of phenotype of variants of the essential replicative polymerase-delta carrying missense mutations in its active site

  6. POLE and POLD1 mutations explain a fraction of familial CRC (show CALR Proteins) and polyposis. Sequencing the proofreading domains of POLE and POLD1 should be considered in routine genetic diagnostics.

  7. Germline mutations in the proofreading domains of 2 DNA polymerases (POLE and POLD1) have been associated with a dominantly inherited, highly penetrant syndrome of oligo adenomatous polyposis and early-age-of-diagnosis colorectal and endometrial cancer.

  8. POLE and POLD1 mutations are associated with endometrial cancer.

  9. a single-codon deletion in POLD1 affecting the polymerase active site causes a markedly different phenotype that includes lipodystrophy.

  10. Germline and somatic polymerase epsilon and delta mutations define a new class of hypermutated colorectal and endometrial cancers.

Mouse (Murine) Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) interaction partners

  1. reducing expression of individual PRMT7 (show PRMT7 Proteins) target DNA repair genes showed that only the catalytic subunit of DNA polymerase (show POLB Proteins), POLD1, was able to resensitize PRMT7 (show PRMT7 Proteins) knock-down cells to DNA-damaging agents.

  2. A point mutation (D400A) in the proofreading domain of DNA polymerase delta, encoded by the Pold1 gene, inactivates the 3' --> 5' exonuclease (show EXOSC10 Proteins) of poldelta and causes a mutator and epithelial cancer phenotype in a recessive manner.

  3. Heterozygous mutation at L604 in the polymerase active site of DNA polymerase delta reduces life span, increases genomic instability, and accelerates tumorigenesis in an allele-specific manner, novel findings that have implications for human cancer.

  4. DNA polymerase delta is essential for mammalian early embryogenesis, and the 3'-5' exonuclease (show EXOSC10 Proteins) activity of DNA polymerase delta is dispensable for normal development but necessary to suppress tumorigenesis

Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) Protein Profile

Protein Summary

This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.

Alternative names and synonyms associated with Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1)

  • DNA-polymerase-delta (DNApol-delta)
  • DNA polymerase delta (POLD1)
  • polymerase (DNA-directed), delta 3, accessory subunit (POLD3)
  • polymerase (DNA-directed), delta 3, accessory subunit (pold3)
  • polymerase (DNA directed), delta 1, catalytic subunit (POLD1)
  • polymerase (DNA directed), delta 1, catalytic subunit (pold1)
  • polymerase (DNA directed), delta 1, catalytic subunit 125kDa (POLD1)
  • polymerase (DNA directed), delta 1, catalytic subunit (Pold1)
  • 125kDa protein
  • 5949 protein
  • CAA61369 protein
  • CDC2 protein
  • CG5949 protein
  • CRCS10 protein
  • Dmel\\CG5949 protein
  • Dm Poldelta protein
  • dnapol delta protein
  • DNA Pol Delta protein
  • l(3)72Ac protein
  • POLD protein
  • POLD3 protein
  • Poldelta protein
  • Pol delta protein

Protein level used designations for POLD1

CG5949-PA , DNA polymerase delta , DNA polymerase-delta , DNApol-delta-PA , lethal (3) 72Ac , DNA polymerase delta catalytic subunit , DNA-dependent DNA polymerase , DNA polymerase delta subunit 3 , polymerase (DNA directed), delta 3 , polymerase (DNA-directed), delta 3, accessory subunit , DNA-directed DNA polymerase delta 3 , DNA polymerase subunit delta 3 , polymerase (DNA directed), delta 1, catalytic subunit 125kDa , DNA-directed DNA polymerase delta 1 , DNA polymerase delta catalytic subunit-like , CDC2 homolog , DNA polymerase subunit delta p125 , DNA polymerase delta 1, catalytic domain , DNA polymerase delta, catalytic subunit

GENE ID SPECIES
39746 Drosophila melanogaster
548092 Glycine max
419053 Gallus gallus
451422 Pan troglodytes
476806 Canis lupus familiaris
549310 Xenopus (Silurana) tropicalis
693601 Macaca mulatta
100051966 Equus caballus
456228 Pan troglodytes
610047 Canis lupus familiaris
719262 Macaca mulatta
734063 Xenopus (Silurana) tropicalis
100052455 Equus caballus
100389890 Callithrix jacchus
100456571 Pongo abelii
100525752 Sus scrofa
5424 Homo sapiens
18971 Mus musculus
59294 Rattus norvegicus
281990 Bos taurus
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