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anti-Human Glutathione Peroxidase 2 Antibodies:
anti-Mouse (Murine) Glutathione Peroxidase 2 Antibodies:
anti-Rat (Rattus) Glutathione Peroxidase 2 Antibodies:
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Human Polyclonal Glutathione Peroxidase 2 Primary Antibody for IHC, ELISA - ABIN250547
Esworthy, Yang, Frankel, Chu: Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice. in The Journal of nutrition 2005
Show all 6 Pubmed References
Human Polyclonal Glutathione Peroxidase 2 Primary Antibody for ELISA, WB - ABIN185424
McGrath-Morrow, Lauer, Yee, Neptune, Podowski, Thimmulappa, OReilly, Biswal: Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia. in American journal of physiology. Lung cellular and molecular physiology 2009
Show all 3 Pubmed References
Results showed that the expression of GPX2 was significantly up-regulated within esophageal squamous cell carcinoma tissues.
Glutathione peroxidase 2 expression is a novel independent prognostic biomarker for gastric carcinoma that may be used to devise personalized therapeutic regimens and precision treatments for this disease
glutathione peroxidase 2 overexpression contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients.
Cardamonin exposure and selenium availability regulate expression of HO-1 (show HMOX1 Antibodies), GPX2 and TrxR1 (show TXNRD1 Antibodies) in human intestinal cells.
GPX2 underexpression is associated with advanced tumor status and implicated unfavorable clinical outcome of UCs, suggesting its role in tumor progression and may serve as a theranostic biomarker of UCs.
high GPx2 expression was associated with early tumor recurrence, particularly in the recently identified aggressive subtype of human colon cancer.
Patients with high GPX2 expression in biopsy specimen had significantly lower prostate-specific antigen recurrence-free survival and overall survival than those with no GPX2 expression.
miR (show MLXIP Antibodies)-185 plays a role in up-regulation of GPX2 and SEPHS2 (show SEPHS2 Antibodies) expression.
A role of GPx2, TrxR2 (show TXNRD2 Antibodies) and TrxR3 (show TXNRD3 Antibodies) in proliferation, apoptosis and, therefore, also during cancer development.
A GPx2-independent decrease in tumor development by selenium (Se) and detrimental effects of the Nrf2 (show GABPA Antibodies)-activator sulforaphane in moderate Se deficiency.
The authors cloned cytosolic glutathione peroxidase (GPx1 (show GPX1 Antibodies)) and phospholipid hydroperoxide glutathione peroxidase (GPx4 (show GPX4 Antibodies)) genes in rainbow trout (Oncorhynchus mykiss). Constitutive mRNA expression and responsiveness to Se availability was analysed.
High glutathione peroxidase 2 expression is associated with radiation induced lung disease.
we propose that ileocolitis in the GPx1 (show GPX1 Antibodies)/2-double-knockout mice is caused by Nox1 (show NOX1 Antibodies), which is induced by TNF (show TNF Antibodies)
GPx2 is up-regulated in dysplastic colonic crypts, where it appears to act inhibit apoptosis and, thus, supports tumor development.
Candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 (show GPX1 Antibodies) and -2, were analyzed.
it is concluded that GPx2, although supporting tumor growth, inhibits inflammation-mediated tumorigenesis, but the protective effect of selenium does not strictly depend on GPx2 expression
study indicates GI-GPx is spatiotemporally expressed in embryonic organs during organogenesis and may also perform a mutual compensatory role with cGPx (show GPX1 Antibodies) in protecting embryos and extraembryonic tissues against reactive oxygen species
Loss of Gpx2 is associated with diet induced severe colitis.
In GPx2 KO mice, an increase in GPx1 (show GPX1 Antibodies) can only partially compensate for GPx2, even under selenium supplementation, indicating that GPx2 is the major antiapoptotic GPx (show PRDX6 Antibodies) in the colon.
Genes encoding the antioxidants GPX2 and GSTO 1-1 (show GSTO1 Antibodies) are common inflammatory genes expressed upon induction of allergic airway inflammation, and independently of allergic susceptibility.
GPX1 (show GPX1 Antibodies)-DKO and GPX2-DKO mice are highly susceptible to bacteria-associated inflammation and cancer.
This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described.
gastrointestinal glutathione peroxidase
, glutathione peroxidase 2
, glutathione peroxidase-related protein 2
, glutathione peroxidase type 2
, glutathione peroxidase-gastrointestinal
, intestinal GPx