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functions as an essential component in two important signal transduction pathways and establishes a novel role for Ecsit as a cofactor for Smad proteins in the bone morphogenetic protein signaling pathway
mediates virus-triggered type I IFN induction by bridging RIG-I (show DDX58 Proteins) and MDA5 (show IFIH1 Proteins) to the VISA (show MAVS Proteins) complex
Ubiquitination of ECSIT might have a role in the regulation of NF-kappaB (show NFKB1 Proteins) activity in TLR4 (show TLR4 Proteins) signaling.
Authors conclude that ECSIT appears to be a novel Hepatitis B virus X protein-interacting signal molecule (show WNT4 Proteins) and their interaction is mechanistically important in IL-1beta (show IL1B Proteins) induction of NF-kappaB (show NFKB1 Proteins) activation.
Data show that the ECSIT (evolutionarily conserved signaling intermediate in Toll (show TLR4 Proteins) pathways) complex, including MEKK7 (TAK1 (show MAP3K7 Proteins)) and TNF receptor-associated factor 6 (TRAF6 (show TRAF6 Proteins)), plays a role in Toll-like receptor 4 (show TLR4 Proteins) -mediated signals to activate NF-kappa B (show NFKB1 Proteins).
TRIM59 interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway.
Study shows a mitochondrial function for Ecsit in the assembly of mitochondrial complex I, an N-terminal targeting signal directs Ecsit to mitochondria, where it interacts with assembly chaperone NDUFAF1 (show NDUFAF1 Proteins).
Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa- B. Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase (By similarity).
, ECSIT homolog (Drosophila)
, evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial-like
, evolutionarily conserved signaling intermediate in Toll pathway
, evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
, signaling intermediate in Toll pathway-evolutionarily conserved
, ECSIT homolog
, likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved