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Human Polyclonal IKBKE Primary Antibody for ELISA, WB - ABIN4224388
Rajsbaum, Versteeg, Schmid, Maestre, Belicha-Villanueva, Martínez-Romero, Patel, Morrison, Pisanelli, Miorin, Laurent-Rolle, Moulton, Stein, Fernandez-Sesma, tenOever, García-Sastre: Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response. in Immunity 2014
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Human Monoclonal IKBKE Primary Antibody for ELISA, WB - ABIN969213
Boehm, Zhao, Yao, Kim, Firestein, Dunn, Sjostrom, Garraway, Weremowicz, Richardson, Greulich, Stewart, Mulvey, Shen, Ambrogio, Hirozane-Kishikawa, Hill, Vidal, Meyerson, Grenier, Hinkle, Root et al.: Integrative genomic approaches identify IKBKE as a breast cancer oncogene. ... in Cell 2007
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Human Monoclonal IKBKE Primary Antibody for ELISA, WB - ABIN966381
Luttjeboer, Harada, Hughes, Johnson, Lilford, Mol: Tubal flushing for subfertility. in Cochrane database of systematic reviews (Online) 2007
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Human Polyclonal IKBKE Primary Antibody for ICC, IF - ABIN4324307
Sun, Sammut, Wang, Kurihara, Windle, Roodman, Galson: TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013
Human Polyclonal IKBKE Primary Antibody for ELISA, IHC - ABIN4324306
Péant, Diallo, Lessard, Delvoye, Le Page, Saad, Mes-Masson: Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer. in Molecular cancer research : MCR 2007
results demonstrate that Sphingosine 1-phosphate lyase (SPL (show SGPL1 Antibodies)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon and SPL (show SGPL1 Antibodies), which provides a mechanistic understanding of the pro-IFN activity of SPL (show SGPL1 Antibodies)
Virus-activated kinase IKKepsilon phosphorylated YAP (show YAP1 Antibodies) at Ser403 and thereby triggered degradation of YAP (show YAP1 Antibodies) in lysosomes and, consequently, relief of YAP (show YAP1 Antibodies)-mediated inhibition of the cellular antiviral response.
We then determined that YAP1 (show YAP1 Antibodies) negatively regulates miR (show MLXIP Antibodies)-let-7b/i by overexpressing and silencing YAP1 (show YAP1 Antibodies) expression. In addition, miR (show MLXIP Antibodies)-let-7b/i feedback decreases the expression of IKBKE and YAP1 (show YAP1 Antibodies) and suppresses the transportation of YAP1 (show YAP1 Antibodies) located in the nucleus. Therefore, the regulatory feedback circuit of IKBKE upward arrow-->YAP1 (show YAP1 Antibodies) upward arrow-->miR (show MLXIP Antibodies)-let-7b/i downward arrow-->IKBKE upward arrow dictates glioblastoma progress...
our findings highlight the functional importance of IKBKE in pancreatic cancer
we define a pathobiologic function for IKKepsilon in reprogramming glucose metabolism and driving progression in pancreatic ductal adenocarcinoma
demonstrate a key role of TBK1 (show TBK1 Antibodies)/IKKepsilon in the survival and proliferation of HTLV-1-transformed T cells
Data suggest that changes in inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKepsilon) and TANK-binding kinase 1 (TBK1 (show TBK1 Antibodies)) expression may be involved in the development of intestinal-type gastric cancer.
Live NiV infection, but not a recombinant NiV lacking the M protein (show MYOM2 Antibodies), reduced the levels of endogenous TRIM6 (show TRIM6 Antibodies) protein expression. To our knowledge, matrix proteins of paramyxoviruses have never been reported to be involved in innate immune antagonism. We report here a novel mechanism of viral innate immune evasion by targeting TRIM6 (show TRIM6 Antibodies), IKKepsilon and unanchored polyubiquitin (show UBB Antibodies) chains.
The adaptor molecule RAIDD (show CRADD Antibodies) coordinates IKKepsilon and IRF7 (show IRF7 Antibodies) interaction to ensure efficient expression of type I interferon (show IFNA Antibodies).
These findings collectively support the conclusion that IKK (show CHUK Antibodies) modulates innate immune signaling cascades via phosphorylating the RIG-I (show DDX58 Antibodies) cytosolic sensor, providing a feedback regulatory mechanism.
REGgamma-mediated control of IkappaBvarepsilon contributes to NFkappaB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury
Suggest that by reducing production of cAMP in adipocytes, PDE3B (show PDE3B Antibodies), IKKepsilon and TBK1 (show TBK1 Antibodies) may contribute to the repression of energy expenditure during obesity.
A role for APPL1 (show APPL1 Antibodies) in TLR3 (show TLR3 Antibodies)/4-dependent TBK1 (show TBK1 Antibodies) and IKKepsilon activation in macrophages.
The results highlight the importance of the C-terminal region in the functional activity of IKKepsilon in innate immune response
tic (show ARNTL Antibodies) ablation of IKBKE resulted in enhanced and prolonged priming of the NLRP3 (show NLRP3 Antibodies) inflammasome in cultured macrophages, in hypertrophic adipose tissue, and in livers of hypercholesterolemic mice.
novel insight into IKKepsilon, which is involved in adipose tissue inflammation during the development of obesity
miR (show MLXIP Antibodies)-339-5p inhibits expression of the pro-inflammatory factors in alcohol-induced brain inflammation through the NF-kappaB (show NFKB1 Antibodies) pathway by abolishing IKK-beta (show IKBKB Antibodies) and IKK-epsilon activity.
IKKepsilon deficiency inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice.
IKKepsilon is expressed in neurons and is upregulated in the hypothalamus of obese mice, contributing to insulin (show INS Antibodies) and leptin (show LEP Antibodies) resistance.
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon-like
, I-kappa-B kinase epsilon
, IKK-related kinase epsilon
, inducible I kappa-B kinase
, inducible IkappaB kinase
, inhibitor of kappaB kinase epsilon
, inducible IKappaB kinase