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YPEL5 silencing enhanced the induction of IFNB1 (show IFNB1 ELISA Kits) by pattern recognition receptors and phosphorylation of TBK1 (show TBK1 ELISA Kits)/IKBKE kinases, whereas co-immunoprecipitation experiments revealed that YPEL5 interacted physically with IKBKE.
results demonstrate that Sphingosine 1-phosphate lyase (SPL (show SGPL1 ELISA Kits)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon and SPL (show SGPL1 ELISA Kits), which provides a mechanistic understanding of the pro-IFN activity of SPL (show SGPL1 ELISA Kits)
Virus-activated kinase IKKepsilon phosphorylated YAP (show YAP1 ELISA Kits) at Ser403 and thereby triggered degradation of YAP (show YAP1 ELISA Kits) in lysosomes and, consequently, relief of YAP (show YAP1 ELISA Kits)-mediated inhibition of the cellular antiviral response.
We then determined that YAP1 (show YAP1 ELISA Kits) negatively regulates miR (show MLXIP ELISA Kits)-let-7b/i by overexpressing and silencing YAP1 (show YAP1 ELISA Kits) expression. In addition, miR (show MLXIP ELISA Kits)-let-7b/i feedback decreases the expression of IKBKE and YAP1 (show YAP1 ELISA Kits) and suppresses the transportation of YAP1 (show YAP1 ELISA Kits) located in the nucleus. Therefore, the regulatory feedback circuit of IKBKE upward arrow-->YAP1 (show YAP1 ELISA Kits) upward arrow-->miR (show MLXIP ELISA Kits)-let-7b/i downward arrow-->IKBKE upward arrow dictates glioblastoma progress...
our findings highlight the functional importance of IKBKE in pancreatic cancer
we define a pathobiologic function for IKKepsilon in reprogramming glucose metabolism and driving progression in pancreatic ductal adenocarcinoma
demonstrate a key role of TBK1 (show TBK1 ELISA Kits)/IKKepsilon in the survival and proliferation of HTLV-1-transformed T cells
Data suggest that changes in inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKepsilon) and TANK-binding kinase 1 (TBK1 (show TBK1 ELISA Kits)) expression may be involved in the development of intestinal-type gastric cancer.
Live NiV infection, but not a recombinant NiV lacking the M protein (show MYOM2 ELISA Kits), reduced the levels of endogenous TRIM6 (show TRIM6 ELISA Kits) protein expression. To our knowledge, matrix proteins of paramyxoviruses have never been reported to be involved in innate immune antagonism. We report here a novel mechanism of viral innate immune evasion by targeting TRIM6 (show TRIM6 ELISA Kits), IKKepsilon and unanchored polyubiquitin (show UBB ELISA Kits) chains.
The adaptor molecule RAIDD (show CRADD ELISA Kits) coordinates IKKepsilon and IRF7 (show IRF7 ELISA Kits) interaction to ensure efficient expression of type I interferon (show IFNA ELISA Kits).
IKKepsilon promotes NFATc1 (show NFATC1 ELISA Kits) phosphorylation and inhibits T cell responses, identifying IKKepsilon as a crucial negative regulator of T cell activation and a potential target for immunotherapy.
REGgamma-mediated control of IkappaBvarepsilon contributes to NFkappaB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury
Suggest that by reducing production of cAMP in adipocytes, PDE3B, IKKepsilon and TBK1 (show TBK1 ELISA Kits) may contribute to the repression of energy expenditure during obesity.
A role for APPL1 (show APPL1 ELISA Kits) in TLR3 (show TLR3 ELISA Kits)/4-dependent TBK1 (show TBK1 ELISA Kits) and IKKepsilon activation in macrophages.
The results highlight the importance of the C-terminal region in the functional activity of IKKepsilon in innate immune response
tic (show ARNTL ELISA Kits) ablation of IKBKE resulted in enhanced and prolonged priming of the NLRP3 (show NLRP3 ELISA Kits) inflammasome in cultured macrophages, in hypertrophic adipose tissue, and in livers of hypercholesterolemic mice.
novel insight into IKKepsilon, which is involved in adipose tissue inflammation during the development of obesity
miR (show MLXIP ELISA Kits)-339-5p inhibits expression of the pro-inflammatory factors in alcohol-induced brain inflammation through the NF-kappaB (show NFKB1 ELISA Kits) pathway by abolishing IKK-beta (show IKBKB ELISA Kits) and IKK-epsilon activity.
IKKepsilon deficiency inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice.
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon-like
, I-kappa-B kinase epsilon
, IKK-related kinase epsilon
, inducible I kappa-B kinase
, inducible IkappaB kinase
, inhibitor of kappaB kinase epsilon
, inducible IKappaB kinase