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IRAK2 L392V showed intact binding to, but impaired ubiquitination of, tumor necrosis factor (show TNF ELISA Kits) receptor-associated factor 6, a vital step in signal transduction
This for the first time implicates human IRAK2 in a human disease and highlights the R214G IRAK2 variant as a potential novel and broadly applicable biomarker for disease or as a therapeutic intervention point.
Human miR (show MLXIP ELISA Kits)-373 is silenced by histone modification in lung cancer cells and is a negative regulator of the mesenchymal phenotype through downstream IRAK2 and LAMP1 (show LAMP1 ELISA Kits) target genes.
Results suggest that D431E-IRAK2 (interleukin-1 receptor-associated kinase-2) increases NF-kappaB (show NFKB1 ELISA Kits) activation by promoting TRAF6 (show TRAF6 ELISA Kits) ubiquitination by enhancing TNF Receptor-Associated Factor 6 (TRAF6 (show TRAF6 ELISA Kits))-IRAK2 interaction.
These findings demonstrate an unexpected linkage of the innate immunity machinery to unfolded protein response signaling, revealing IRAK2 as a novel amplifier of the IRE1 (show ERN1 ELISA Kits) pathway.
Human interleukin-1 receptor-associated kinase-2 is essential for Toll (show TLR4 ELISA Kits)-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha (show TNF ELISA Kits).
analysis of differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1 (show IRAK1 ELISA Kits)) and IRAK-2 by microRNA-146a and NF-kappaB (show NFKB1 ELISA Kits) in stressed human astroglial cells and in Alzheimer disease
Our data show that interleukin-1R-associated kinase 2 is a novel and critical component of TGFbeta (show TGFB1 ELISA Kits) signaling.
the crystal structure of the MyD88 (show MYD88 ELISA Kits)-IRAK4 (show IRAK4 ELISA Kits)-IRAK2 death domain (DD) complex, which surprisingly reveals a left-handed helical oligomer that consists of 6 MyD88 (show MYD88 ELISA Kits), 4 IRAK4 (show IRAK4 ELISA Kits) and 4 IRAK2 DDs
CTCF (show CTCF ELISA Kits) plays a major role in IRAK2 transcription; EMSA revealed a CTCF (show CTCF ELISA Kits)-binding site within the mouse Irak2 promoter
Our results establish that the IRAK2-TRAF6 (show TRAF6 ELISA Kits) interaction is rate limiting for the late, but not the early phase of cytokine production in bone marrow-derived macrophages and plasmacytoid dendritic cells
IRAK2 plays a key role in the TLR9 (show TLR9 ELISA Kits)-mediated transcriptional regulation of Irak-m (show IRAK3 ELISA Kits) expression by sustaining activation of PKD1 (show PKD1 ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits)
IRAK-2 mediates pathology in a CD4 T cell specific manner by promoting Th17 cell development through enhancement of IL-1beta-induced activation of transcription factors RORgammat and BATF.
the kinase activity of IRAK2 is required for the optimal activation of mitogen-activated protein kinase (show MAPK1 ELISA Kits) signaling, which regulates cytokine and chemokine (show CCL1 ELISA Kits) production at posttranscriptional levels.
IRAK2 is a negative regulator of Toll (show TLR4 ELISA Kits)-like receptor (TLR)9 (show TLR9 ELISA Kits)-induced interferon (show IFNA ELISA Kits) production in plasmacytoid dendritic cells.
Alternative splicing of the Irak2 gene in mice will generate agonistic or antagonistic Irak2 isoforms, which is likely to have consequences for the regulation of Toll (show TLR4 ELISA Kits)-like receptors signaling.
TRAF6 (show TRAF6 ELISA Kits) and interleukin receptor-associated kinase 2 are novel binding partners for PS1 (show PSEN1 ELISA Kits), and IL-1R1 is a new substrate for presenilin-dependent gamma-secretase cleavage
These results reveal that IRAK2 is required for LPS (show TLR4 ELISA Kits)-mediated post-transcriptional control of cytokine and chemokine (show CCL1 ELISA Kits) expression, which plays an essential role in TLR4 (show TLR4 ELISA Kits)-induced septic shock.
Data demonstrate that IRAK-2 is an essential component of the early TLR response in MOLF/Ei mice and show a distinct pathway of p38 (show CRK ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits) activation in this model organism.
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.
interleukin-1 receptor associated kinase-2
, interleukin-1 receptor-associated kinase-like 2
, interleukin-1 receptor-associated kinase 2c