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Browse our IRAK3 Proteins (IRAK3)

Full name:
Interleukin-1 Receptor-Associated Kinase 3 Proteins (IRAK3)
On are 8 Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) Proteins from 6 different suppliers available. Additionally we are shipping IRAK3 Antibodies (147) and IRAK3 Kits (12) and many more products for this protein. A total of 181 IRAK3 products are currently listed.
4833428C18Rik, AI563835, ASRT5, IRAK-M, IRAK3, IrakM, si:dkey-150i15.2
list all proteins Gene Name GeneID UniProt
IRAK3 11213 Q9Y616
IRAK3 73914 Q8K4B2
Rat IRAK3 IRAK3 314870  

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IRAK3 Proteins (IRAK3) by Origin

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More Proteins for IRAK3 Interaction Partners

Human Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) interaction partners

  1. Alpha-Melanocyte-Stimulating Hormone (show POMC Proteins) Suppresses TLR2-Mediated Functional Responses through IRAK-M in Normal Human Keratinocytes

  2. IRAK3 methylation was associated with tumor stage and poor prognosis of hepatocellular carcinoma patients.

  3. The structure function of the death domain of human IRAK-M

  4. HIF1alpha (show HIF1A Proteins) is a regulator of monocyte functional re-programming in sepsis via regulating IRAKM expression.

  5. IRAK-M expression is upregulated in peripheral blood cells from idiopathic pulmonary fibrosis patients

  6. our study demonstrates that patients carrying IRAK-M+22148 G haplotype are more susceptible to sepsis than patients carrying IRAK-M+22148 A haplotype, suggesting that IRAK-M+22148 G haplotype might be a risk factor for sepsis.

  7. These data indicate the enhancing effect of IRAK-M on epithelial human rhinovirus-16 infection, which is partly through the autophagic pathway.

  8. IRAK-M mediates TLR7 (show TLR7 Proteins)-induced MEKK3 (show MAP3K3 Proteins)-dependent second wave NFjB activation to produce inhibitory molecules

  9. the tested variations of IRAK-M and SIGIRR (show SIGIRR Proteins) genes do not confer a relevant role in the susceptibility to systemic lupus erythematosus in European-descent populations

  10. these data identify an important signaling regulator in human macrophages that is used by surfactant to control the long-term alveolar inflammatory response, i.e., enhanced IRAK-M activity.

Mouse (Murine) Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) interaction partners

  1. IRAK-M may also contribute to myofibroblast conversion.

  2. These data demonstrate LTi cells are present in the stomach and promote lymphoid follicle formation in response to infection, but are limited by IRAK-M expression.

  3. IL-7 (show IL7 Proteins) reduced IRAK-M expression and attenuated immune tolerance induced by either LPS (show TLR4 Proteins) or CpGA

  4. the results suggest that IRAK-M may be targeted by L. donovani to inhibit TLR-mediated proinflammatory response late during in vitro infection.

  5. These data indicate expression of IRAK-M skews lung macrophages toward an alternatively activated profibrotic phenotype, which promotes collagen production, leading to the progression of experimental pulmonary fibrosis.

  6. Our study identifies the DAP12 (show TYROBP Proteins)/IRAK-M/IL-10 (show IL10 Proteins) to be a novel molecular pathway in APCs (show APCS Proteins) exploited by mycobacterial pathogens, allowing infection a foothold in the lung.

  7. This study illustrates how the modulation of innate immune pathways through IRAK-M influences the development of autoimmune diabetes.

  8. novel findings provide new insights into the understanding of negative regulatory mechanisms of the TLR4 (show TLR4 Proteins) signaling pathway.

  9. Altered gut (show GUSB Proteins) microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice.

  10. IRAK-M plays an important role in alcohol-induced liver injury and IRAK-M negatively regulates the innate and possibly the adaptive immune response in the liver reacting to acute insult by alcohol.

IRAK3 Protein Profile

Protein Summary

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with IRAK3

  • interleukin-1 receptor-associated kinase 3 (IRAK3)
  • interleukin-1 receptor-associated kinase 3 (irak3)
  • interleukin-1 receptor-associated kinase 3 (Irak3)
  • 4833428C18Rik protein
  • AI563835 protein
  • ASRT5 protein
  • IRAK-M protein
  • IRAK3 protein
  • IrakM protein
  • si:dkey-150i15.2 protein

Protein level used designations for IRAK3

interleukin-1 receptor-associated kinase 3 , interleukin-1 receptor-associated kinase 3-like , IL-1 receptor-associated kinase M , interleukin-1 receptor-associated kinase M , IRAK-3

100441850 Pongo abelii
100483119 Ailuropoda melanoleuca
467058 Pan troglodytes
481150 Canis lupus familiaris
567444 Danio rerio
717845 Macaca mulatta
100024979 Monodelphis domestica
100583020 Nomascus leucogenys
11213 Homo sapiens
510342 Bos taurus
73914 Mus musculus
314870 Rattus norvegicus
100514645 Sus scrofa
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