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Cow (Bovine) Monoclonal ARF1 Primary Antibody for ICC, FACS - ABIN152664
Lu, Horstmann, Ng, Hong: Regulation of Golgi structure and function by ARF-like protein 1 (Arl1). in Journal of cell science 2002
Show all 11 Pubmed References
Arabidopsis thaliana Polyclonal ARF1 Primary Antibody for IF, WB - ABIN2688655
Pimpl, Movafeghi, Coughlan, Denecke, Hillmer, Robinson: In situ localization and in vitro induction of plant COPI-coated vesicles. in The Plant cell 2001
Show all 8 Pubmed References
Identification of Sec71 as a guanine nucleotide exchange factor (show ARHGEF12 Antibodies) for Arf1 that preferentially interacts with its GDP-bound form. Like Arf1, Sec71 is also important for dendrite pruning, but not for apoptosis of sensory neurons.
Suggest a model in which Arf1/COPI machinery acts to control endoplasmic reticulum-lipid droplet connections for localization of key enzymes of triglyceride storage and catabolism.
ARF1-Asrij endocytic axis modulates signals that govern hematopoietic development.
Sata indicate that the Class I Arf GTPase (show ARL8A Antibodies) is a central component in WRC-driven lamellipodium formation.
Results suggest that N-cadherin (show CDH2 Antibodies) is regulated in a Schizo/Loner- and d-Arf1-dependent manner.
Experiments using a mutant form of ARF1 affecting GTP (show AK3 Antibodies) hydrolysis suggest that ARF1[GTP (show AK3 Antibodies)] is functionally required for the tubules to form.
ARNO-ARF1 regulates formation of podosomes by inhibition of RhoA/myosin-II and promotion of actin core assembly.
Activation of ARF1 dissociates ADRP (show PLIN2 Antibodies) from lipid droplets. A constitute active form of ARF1 (ARF1Q71I) promotes HCV assembly. ADRP (show PLIN2 Antibodies) played a positive role in Hepatitis C virus replication and negative role in Hepatitis C virus assembly.
ARF1 may reverse CAM (show CALM1 Antibodies)-DR by regulating phosphorylation of p27 (show PAK2 Antibodies) at T157 in MM. our data shed new light on the molecular mechanism of CAM (show CALM1 Antibodies)-DR in MM, and targeting ARF1 may be a novel therapeutic approach for improving the effectiveness of chemotherapy in MM.
We report here that 2-methylcoprophilinamide (M-COPA (show COPA Antibodies)), a compound that induces disassembly of the Golgi apparatus by inactivating ADP-ribosylation factor 1 (Arf1), suppresses Stx (show ST8SIA2 Antibodies)-induced apoptosis. M-COPA (show COPA Antibodies) inhibited transport of Stx (show ST8SIA2 Antibodies) from the plasma membrane to the Golgi apparatus and suppressed degradation of anti-apoptotic proteins and the activation of caspases
observations indicate that Arf1 and Arf3 (show ARF3 Antibodies) as well as Arf6 (show ARF6 Antibodies) play important roles in cytokinesis.
ARF1 activates the MAPK (show MAPK1 Antibodies) pathway likely using the Golgi as a main platform, which in turn activates the cytoplasmic RSK1 (show RPS6KA1 Antibodies), leading to cell proliferation.
Data indicate that ADP-ribosylation factor 1 (Arf1) colocalizes with chromogranin A (show CHGA Antibodies) and regulates secretion of insulin like growth factor 1 (IGF-1 (show IGF1 Antibodies)) and is required for anchorage dependent growth.
this study reports the cryo-electron microscopy structures of the Nef- and Arf1-bound AP-1 (show FOSB Antibodies) trimer in the active and inactive states.
ARF1A1C is essential for recycling of PIN (show DYNLL1 Antibodies) auxin transporters and for various auxin-dependent developmental processes.[BEX1 (show BEX1 Antibodies)][ARF1A1C]
Study shows that ARF (show CDKN2A Antibodies) DNA-binding domains ahomodimerize to generate cooperative DNA binding, which is critical for in vivo ARF5 (show ARF5 Antibodies)/MP function. Strikingly, DNA-contacting residues are conserved between ARFs, and found that monomers have the same intrinsic specificity; ARF1 and ARF5 (show ARF5 Antibodies) homodimers, however, differ in spacing tolerated between binding sites.
Data indicate that ArfGAP domain8 (AGD8) and ARF (show CDKN2A Antibodies)-GAP domain 9 (AGD9), are involved in the recruitment of Arf1-GDP to the Golgi apparatus .
Data show that IAA8 is involved in lateral root formation, and that this process is regulated through the interaction with the TIR1 auxin receptor and ARF (show CDKN2A Antibodies) transcription factors in the nucleus.
The authors showed that Arf1 interacted with the viral p27 (show CDKN1B Antibodies) replication protein within the virus-induced large punctate structures of the endoplasmic reticulum membrane.
unlike arf2 (show ARF4 Antibodies) mutations, an arf1 mutation increased transcription of Aux/IAA genes in Arabidopsis flowers, supporting previous biochemical studies that indicated that ARF1 is a transcriptional repressor
The half-life of degradation of ARF1, and its role in auxin metabolism, are reported.
ARF1 may be a plausible inter-player that mediates the transition to osteoclast fusion at multiple steps during osteoclast differentiation.
Increased gene dosage of Ink4a (show CDKN2A Antibodies), Arf1 and p53 (show TP53 Antibodies) delays age-associated central nervous system functional decline.
ARF1/TBCE (show TBCE Antibodies)-mediated cross-talk that coordinates COPI formation and tubulin (show TUBB Antibodies) polymerization at the Golgi.
These data establish for the first time that the Arf1 gene is indispensable for mouse embryonic development after implantation.
Arf (show CDKN2A Antibodies) modulates LRP6 (show LRP6 Antibodies) phosphorylation for the transduction of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
Down-regulation of ADP-ribosylation factor results in corneal neovascularization regression.
ARF1-dependent trafficking of procathepsin B and the maturation of autophagosomes results in cathepsin B-mediated trypsinogen activation induced by caerulein.
Egr1 (show EGR1 Antibodies) mediates p53 (show TP53 Antibodies)-independent c-Myc (show MYC Antibodies)-induced apoptosis via a noncanonical ARF (show CDKN2A Antibodies)-dependent transcriptional mechanism
A senescence rescue screen identifies BCL6 (show BCL6 Antibodies) as an inhibitor of anti-proliferative p19(ARF (show CDKN2A Antibodies))-p53 (show TP53 Antibodies) signaling
termination of Arf1 signals mediated through GGA require that Arf1.GTP (show AK3 Antibodies) dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP (show AK3 Antibodies)
Vascular endothelial growth factor receptor-2 (show KDR Antibodies) activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase (show NOS3 Antibodies) activation and nitric oxide release from endothelial cells
Data show that AP-1 (show JUN Antibodies) recruitment to the cell membrane was found to be dependent on myristoylated ADP-ribosylation factor (ARF1), GTP (show AK3 Antibodies) or nonhydrolyzable GTP (show AK3 Antibodies)-analogs, tyrosine signals, and small amounts of phosphoinositides.
NCS-1 (show NCS1 Antibodies)-ARF1 interaction provides evidence for functional cross-talk between Ca(2 (show CA2 Antibodies)+)-dependent and ARF (show CDKN2A Antibodies)-dependent pathways in TGN (show TG Antibodies) to plasma membrane traffic
The ARF1 machinery also might produce movement- and fission-promoting forces through actin polymerization.
Binding of cargo signal peptides to AP-1 (show JUN Antibodies) induces a conformational change in its core domain that greatly enhances its interaction with Arf-1-GTP (show AK3 Antibodies).
findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (show NCS1 Antibodies) in mitochondrial function via its association with several mitochondrial proteins.
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
ADP ribosylation factor at 79F
, ADP-ribosylation factor 1
, tripartite motif-containing 23
, ADP-ribosylation factor domain protein 1
, adp-ribosylation factor 1
, ADP-ribosylation factor 6
, ADP-ribosylation factor GTPase activating protein 3
, ADP-ribosylation factor GTPase activating protein 1