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Data demonstrate the physiological significance of the interaction between the E and H subunits of V-ATPase (show ATP6V1H Proteins) and extend previous studies on the arrangement of subunits on the peripheral stalk of V-ATPase (show ATP6V1H Proteins).
there is an important role for physical association between aldolase and the A, B and E subunits of V-ATPase (show ATP6V1H Proteins) in the regulation of the proton pump
A cDNA encoding a novel putative neuron-specific isoform of vacuolar proton-translocating ATPase (V-ATPase), NM9.2, was isolated from rat and mouse.
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3.
H(+)-transporting two-sector ATPase, subunit H
, V-ATPase 9.2 kDa membrane accessory protein
, V-ATPase H subunit
, V-ATPase M9.2 subunit
, V-ATPase subunit e 1
, V-type proton ATPase subunit e 1
, vacuolar ATP synthase subunit H
, vacuolar proton pump H subunit
, vacuolar proton pump subunit e 1
, vacuolar proton-ATPase subunit M9.2
, ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e
, Vacuolar ATP synthase subunit e 1
, vacuolar proton-ATPase subunit ATP6H
, ATPase, H+ transporting lysosomal (vacuolar proton pump), 9.2 kDa
, ATPase, H+ transporting, V0 subunit e
, ATPase, H+ transporting, lysosomal 9kD V0 subunit E
, lysosomal 9kDa
, ATPase, H+ transporting, V0 subunit E
, ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
, ATPase, H+ transporting, lysosomal V0 subunit E1
, D-serine-regulated transcript 1 protein