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Top single-nucleotide polymorphism rs9590614 in VMA8 is located within genes that function in cell-cell signaling and cell migration.
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein.
ATPase, H+ transporting lysosomal, member M
, ATPase, H+ transporting, lysosomal (vacuolar proton pump)
, H(+)-transporting two-sector ATPase, subunit M
, V-ATPase 28 kDa accessory protein
, V-ATPase D subunit
, V-ATPase subunit D
, V-type proton ATPase subunit D
, vacuolar ATP synthase subunit D
, vacuolar H-ATPase subunit D
, vacuolar proton pump D subunit
, vacuolar proton pump delta polypeptide
, vacuolar proton pump subunit D
, vacuolar proton-ATPase subunit D
, ATPase, H+ transporting lysosomal (vacuolar proton pump)
, ATPase, H+ transporting, V1 subunit D
, ATPase, H+ transporting, lysosomal 34kD, V1 subunit D
, lysosomal 34kDa
, hypothetical protein