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Browse our HYAL2 Proteins (HYAL2)

Full name:
Hyaluronidase-2 Proteins (HYAL2)
On are 11 Hyaluronidase-2 (HYAL2) Proteins from 6 different suppliers available. Additionally we are shipping HYAL2 Antibodies (97) and HYAL2 Kits (11) and many more products for this protein. A total of 122 HYAL2 products are currently listed.
AI256841, AU020858, AW555733, hyal2, hyal2a, hyal2b, luca-2, LUCA2, oHyal2, si:dkey-42i9.14, xhyal2
list all proteins Gene Name GeneID UniProt
HYAL2 8692 Q12891
HYAL2 15587 O35632
Rat HYAL2 HYAL2 64468  

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HYAL2 Proteins (HYAL2) by Origin

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Rabbit Hyaluronidase-2 (HYAL2) interaction partners

Human Hyaluronidase-2 (HYAL2) interaction partners

  1. Data show that DNA methylation (show HELLS Proteins) at CpG island of hyaluronoglucosaminidase 2 (HYLA2) could be used to identify stage II and III colon cancer patients who are most likely to benefit from 5-flourouracil chemotherapy with respect to progression-free survival.

  2. CD44 (show CD44 Proteins) knock-down in bovine and human chondrocytes results in release of bound HYAL2.

  3. High expression of S100P (show S100P Proteins) and HYAL2 is significantly associated with advanced disease and shorter survival of triple-negative breast cancer and S100P (show S100P Proteins) and HYAL2 could be potential prognostic markers of TNBC.

  4. HYAL2 plays a redundant role in the catalysis of megadalton HA to its 20 kDa intermediate during fertilization.

  5. Lower platelet HYAL2 levels and activity are associated with inflammatory bowel disease.

  6. A strong association between decreased HYAL2 methylation in peripheral blood and BC.

  7. Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.

  8. HAS2 (show HAS2 Proteins)-HYAL2/CD44 (show CD44 Proteins) system may support spontaneous chemokinesis of human cancer cells through self-degradation of HMW-HA to produce LMW-HA by an autocrine mechanism.

  9. Hyaluronan synthases (HAS1 (show HAS1 Proteins)-3) and hyaluronidases (HYAL1 (show HYAL1 Proteins)-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

  10. Overexpression of HYAL2 is associated with colorectal cancer.

Mouse (Murine) Hyaluronidase-2 (HYAL2) interaction partners

  1. Removal of Hyal2 activity resulted in increased levels of hyaluronan creating a risk for cor triatriatum sinister.

  2. hyaluronidase 2 deficiency induces chronic thrombotic microangiopathy with hemolytic anemia in mice.

  3. HYAL1 (show HYAL1 Proteins) is necessary for the breakdown of intracellular HA in the cortex, whereas HYAL2 is essential for the degradation of extracellular HA in all kidney regions

  4. HYAL2 plays a redundant role in the catalysis of megadalton HA to its 20 kDa intermediate during fertilization.

  5. Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction

  6. Hyal-2 enhancement of tumor necrosis factor-alpha (show TNF Proteins)-stimulated cytotoxicity in fibroblasts is blocked by Transforming growth factor-beta1.

  7. Hyaluronidase (show HAase Proteins) induces ovarian granulosa cell apoptosis and is involved in follicular atresia.

  8. murine HYAL2 has a physiological activity in vivo that is relevant for craniovertebral bone formation, maintenance of plasma hyaluronan concentrations, and erythrocyte and platelet homeostasis.

  9. platelets and megakaryocytes contain only hyaluronidase 2 (HYAL2) but not HYAL1 (show HYAL1 Proteins)

Cow (Bovine) Hyaluronidase-2 (HYAL2) interaction partners

  1. CD44 (show CD44 Proteins) knock-down in bovine and human chondrocytes results in release of bound HYAL2.

  2. HYAL2 expression improves the blastocyst rate and embryo quality, an effect which requires CD44 (show CD44 Proteins) activity and MAPK (show MAPK1 Proteins) signaling.

  3. May degrade hyaluronan by analogy to human HYAL2, which is a weak acid-active hyaluronidase (show HAase Proteins). Serves as an entry receptor for jaagsiekte sheep retrovirus in sheep and bovine as well as for enzootic nasal tumor virus in sheep.

HYAL2 Protein Profile

Protein Summary

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.

Alternative names and synonyms associated with HYAL2

  • hyaluronoglucosaminidase 2 (hyal2-b)
  • hyaluronoglucosaminidase 2 (HYAL2)
  • hyaluronoglucosaminidase 2 (hyal2)
  • hyaluronoglucosaminidase 2 (hyal2-a)
  • hyaluronoglucosaminidase 2 (Hyal2)
  • AI256841 protein
  • AU020858 protein
  • AW555733 protein
  • hyal2 protein
  • hyal2a protein
  • hyal2b protein
  • luca-2 protein
  • LUCA2 protein
  • oHyal2 protein
  • si:dkey-42i9.14 protein
  • xhyal2 protein

Protein level used designations for Hyaluronidase-2 Proteins (HYAL2)

hyaluronidase 2 b , hyaluronoglucosaminidase 2 , hyaluronidase-2 , hyaluronidase 2 , hyaluronidase 2 a , hyaluronidase-2-like , PH-20 homolog , PH20 homolog , hyal-2 , hyaluronoglucosaminidase-2 , lung carcinoma protein 2 , lysosomal hyaluronidase , GPI-anchored surface protein , JSRV envelope protein receptor

380470 Xenopus laevis
415908 Gallus gallus
460391 Pan troglodytes
484760 Canis lupus familiaris
559228 Danio rerio
702484 Macaca mulatta
100009375 Oryctolagus cuniculus
100144942 Xenopus (Silurana) tropicalis
100337508 Xenopus laevis
100407141 Callithrix jacchus
100453650 Pongo abelii
8692 Homo sapiens
15587 Mus musculus
64468 Rattus norvegicus
443154 Ovis aries
281838 Bos taurus
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