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Metallothioneins may have a protective role against post-burn inflammation and inflammatory organ damage, at least partly through inhibiting the p38 MAPK (show MAPK14 Proteins) signaling.
Enhanced senescence due to absence of metallothionein (show MT Proteins) genes may shorten lifespan.
The MT2 receptor activates Akt (show AKT1 Proteins)/GSK-3beta/CRMP-2 (show DPYSL2 Proteins) signaling and is necessary and sufficient to mediate functional axonogenesis and synaptic formation in central neurons.
MT1 (show MT1 Proteins)/2 deficiency aggravated depleted uruanium-induced nephrotoxicity, and the molecular mechanisms appeared to be related to the increased oxidative stress and apoptosis, and decreased SGLT expression.
Zinc-binding MT1 (show MT1 Proteins) and MT2 are key modulators of Fc epsilonRI-induced basophil production of IL-4 (show IL4 Proteins).
Metallothionein (show MT Proteins) blocks oxidative DNA damage induced by acute inorganic arsenic exposure
the metal binding abilities of mouse MT2 (mMT2) with divalent (Zn(II) and Cd(II)) and monovalent (Cu(I)) ions were analyzed and compared to those of the mouse MT1 (show MT1 Proteins) (mMT1) isoform.
The results of this study suggest that metallothioneins may play a key role in protecting the kidney against high glucose-induced ROS (show ROS1 Proteins) and subsequent inflammation in diabetic nephropathy.
these results demonstrate that MT-I (show MT1 Proteins)/II knockout mice are more vulnerable to cadmium-induced fetal growth retardation.
Metallothioneins act as negative regulators for IL-27-induced Tr1 cells.
Underexpression of MT2A (show MT2 Proteins) is associated with HPV-positive head and neck cancers.
The present study was undertaken to explore further the interrelationship between p53 (show TP53 Proteins) and metallothioneins.
HMBOX1 (show HMBOX1 Proteins) regulates intracellular free zinc level by interacting with MT2A (show MT2 Proteins) to inhibit apoptosis and promote autophagy in vascular endothelial cells.
Polymorphism of Metallothionein 2A (show MT2 Proteins) modifies Lead Body Burden in workers chronically exposed to the metal.
The findings suggest that MT2A (show MT2 Proteins) gene variation rs28366003 may be implicated in the etiology of sinonasal inverted papilloma in a Polish population
Metallothionein 2A affects the cell respiration by suppressing the expression of mitochondrial protein cytochrome c oxidase subunit II.
MT2A (show MT2 Proteins) was down-regulated in renal cell carcinogenesis.
In the Han population of China, the gene polymorphism of MT2A (show MT2 Proteins)-838G/C is correlated to coronary heart disease.
Electrospray ionization ion mobility mass spectrometry and molecular dynamics simulations reveal new insights into metal-induced conformational changes and the mechanism for metalation of human metallothionein-2A (show MT2 Proteins).
MT2A (show MT2 Proteins) mRNA expression has a significant inverse correlation with Cd and Cu levels in dry inverted papilloma tissue. Inverted papilloma cases with lower average cadmium and copper content were observed to be the most frequent positive MT2A (show MT2 Proteins) mRNA expression.
Expression of MT-1a (show MT1A Proteins), MT-2b and MT-3 (show MT3 Proteins) were significantly higher in high zinc fed pigs.
Metallothioneins have a high content of cysteine residues that bind various heavy metals\; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
, metallothionein 2A