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Browse our Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Proteins (SLC11A2)

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Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Proteins (SLC11A2)
On www.antibodies-online.com are 3 Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) Proteins from 2 different suppliers available. Additionally we are shipping Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Antibodies (89) and Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Kits (16) and many more products for this protein. A total of 110 Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 products are currently listed.
Synonyms:
ATNRAMP2, cb426, DCT1, Dmt1, F8G22.4, F8G22_4, fa07b10, MGC138014, mk, Nramp2, NRAMP metal ion transporter 2, SLC11A2, van, wu:fa07b10, zgc:136699
list all proteins Gene Name GeneID UniProt
Rat SLC11A2 SLC11A2 25715 O54902
SLC11A2 4891 P49281
SLC11A2 18174 P49282

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Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Proteins (SLC11A2) by Origin

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More Proteins for Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Interaction Partners

Zebrafish Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) interaction partners

  1. The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). Whereas wild-type zebrafish DMT1 protein can transport iron, the truncated protein expressed in cdy mutants is not functional.

Human Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) interaction partners

  1. Divalent metal transporter-1 overexpression in endometriosis patients' endometrium can increase iron influx to endometrial cells, inducing oxidative stress-mediated proinflammatory signaling. In turn, endometriosis-related conditions, as iron overload and inflammation (IL-1beta (show IL1B Proteins)), enhance endometriosis patients endometrial DMT1 (show DMRT1 Proteins) expression, creating a vicious circle on DMT-1 (show DMRT1 Proteins)-modulated pathways.

  2. X-ray crystallographic analysis of a 4-component complex comprising the VPS26 (show VPS26A Proteins) & VPS35 (show vps35 Proteins) subunits of retromer, sorting nexin SNX3 (show SNX3 Proteins), & recycling signal from the divalent cation transporter DMT1 (show DMRT1 Proteins)-II; analysis identifies a binding site for canonical recycling signals at the interface between VPS26 (show VPS26A Proteins) & SNX3 (show SNX3 Proteins); shows cooperative interactions among the VPS subunits, SNX3 (show SNX3 Proteins) & cargo that couple signal-recognition to membrane recruitment.

  3. Gene silencing of either CTR1 (show SLC31A1 Proteins) or DMT1 (show DMRT1 Proteins) did not affect copper accumulation in cells, but deficiency in both CTR1 (show SLC31A1 Proteins) and DMT1 (show DMRT1 Proteins) resulted in a complete inhibition of copper uptake.

  4. These data suggest that iron uptake induces the production of ROS (show ROS1 Proteins), which modify DMT1 (show DMRT1 Proteins) endocytic cycling, thus changing the iron transport activity at the apical membrane.

  5. We propose that DMT1 (show DMRT1 Proteins) deficiency negatively affects metabolism and life span of mature erythrocytes; two other aspects of defective erythropoiesis which contribute to the pathophysiology of the disease

  6. Suggest role for divalent cation transporter DMT1 (show DMRT1 Proteins) in the entry of Hg(II) into the intestinal epithelium.

  7. Six months after RYGB surgery, patients exhibit an increase in DMT1 (show DMRT1 Proteins) expression in the enterocytes of the tips of the villi at the proximal jejunum

  8. In Parkinson's disease, increased iron levels are associated with increased Ndfip1 (show NDFIP1 Proteins) expression for the regulation of DMT1 (show DMRT1 Proteins), including abnormal Ndfip1 (show NDFIP1 Proteins) activation in non-neuronal cell types such as astrocytes.

  9. The DMT1 (show DMRT1 Proteins) IVS4 C(+) allele occurred more frequently in WND (show ATP7B Proteins) than in the healthy controls.

  10. DMT1 (show DMRT1 Proteins) not only exports iron from endosomes, but also serves to import the metal into the mitochondria

Mouse (Murine) Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) interaction partners

  1. Ndfip2 (show NDFIP2 Proteins) controls DMT1 in the liver with female mice showing a greater response to altered dietary iron than the male mice

  2. PrP(C (show PRNP Proteins)) promotes, and possibly regulates, the uptake of iron through DMT1 and Zip14 (show SLC39A14 Proteins) via its ferrireductase activity.

  3. This study reveals a critical function for DMT1 in intestinal nonheme-iron absorption for normal growth and development, and that it is not required for the transport of copper, manganese, or zinc.

  4. We propose that DMT1 deficiency negatively affects metabolism and life span of mature erythrocytes; two other aspects of defective erythropoiesis which contribute to the pathophysiology of the disease

  5. Misregulation of DMT1 is implicated in Parkinson's disease.

  6. Suggest role for divalent cation transporter DMT1 in the entry of Hg(II) into the intestinal epithelium.

  7. The Cu uptake in HEK293 cells that over-expressed the 2/-IRE isoform of DMT1 transporter supports our earlier contention that DMT1 transports Cu as Cu(1+).

  8. Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin (show Tf Proteins)-bound iron uptake in mice.

  9. DMT-1 expression in hypothalamic subregions is cre recombinase (show RAG1 Proteins) sensitive, and that central-peripheral pathways may impact beta cell function in the Dmt1 null mouse.

  10. CD61 (show ITGB3 Proteins) regulates the expression of Slc11a2, which is involved in iron transportation in epithelial tissues.

Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) Protein Profile

Protein Summary

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2)

  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)
  • metal transporter NRAMP2 (NRAMP2)
  • manganese transport protein (NRAMP2)
  • NRAMP2 (ARALYDRAFT_891495)
  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 (slc11a2)
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (slc11a2)
  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 (Slc11a2)
  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 (SLC11A2)
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2)
  • ATNRAMP2 protein
  • cb426 protein
  • DCT1 protein
  • Dmt1 protein
  • F8G22.4 protein
  • F8G22_4 protein
  • fa07b10 protein
  • MGC138014 protein
  • mk protein
  • Nramp2 protein
  • NRAMP metal ion transporter 2 protein
  • SLC11A2 protein
  • van protein
  • wu:fa07b10 protein
  • zgc:136699 protein

Protein level used designations for SLC11A2

divalent metal transporter 1 , natural resistance-associated macrophage protein 2 , manganese transport protein , NRAMP2 , solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 , cdy , chardonnay , nramp , DMT-1 , NRAMP 2 , Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2) , divalent cation transporter 1 , microcytic anemia, viable anaemia

GENE ID SPECIES
733595 Sus scrofa
751817 Gallus gallus
841127 Arabidopsis thaliana
5726598 Chlamydomonas reinhardtii
9327403 Arabidopsis lyrata subsp. lyrata
100144712 Xenopus (Silurana) tropicalis
451897 Pan troglodytes
486543 Canis lupus familiaris
512464 Bos taurus
678623 Danio rerio
693986 Macaca mulatta
25715 Rattus norvegicus
4891 Homo sapiens
18174 Mus musculus
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