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Functional impact of mammalian ferroportin mutations studied in zebrafish.
role of ABCG37, IRT1 and FRO2 in root Fe2+ transport systems
role of IRT1 (show PARP3 ELISA Kits) in iron uptake
these results suggest that the His-loop of MTP1 acts as a sensor of cytosolic zinc to maintain an essential level in the cytosol and that the dysfunction of the loop results in an uncontrolled accumulation of zinc in the vacuoles of root cells.
Our results reveal a role of SNX1 (show SNX1 ELISA Kits) for the correct trafficking of IRT1 (show PARP3 ELISA Kits) and, thus, for modulating the activity of the iron uptake machinery
This work establishes a functional link between the dynamics and the lateral polarity of IRT1 (show PARP3 ELISA Kits) and the transport of its substrates, and identifies a molecular mechanism driving polar localization of a cell surface protein (show CD28 ELISA Kits) in plants.
IDF1 directly regulates IRT1 (show PARP3 ELISA Kits) degradation through its RING-type E3 ligase activity.
Data indicate that steady-state mRNA abundance for three representative Fe homeostasis genes, IRT1 (show PARP3 ELISA Kits), bHLH39, and FER1 (show FTH1 ELISA Kits), oscillated in light/dark (LD) cycles or warm/cold environmental cycles.
AtIRT1 transports nicekl (Ni(2 (show VMP1 ELISA Kits)+)) in roots, and strongly suggest that Ni accumulation is further accelerated by AtIRT1 that is expressed in response to excess Ni.
These data suggest a model in which monoubiquitin-dependent internalization/sorting and turnover keep the plasma membrane pool of IRT1 (show PARP3 ELISA Kits) low to ensure proper iron uptake and to prevent metal toxicity.
IRT1 and FRO2 genes are upregulated under iron starvation.
Reduced expression of ferroportin mRNA identifies a subset of infertile women and may constitute a target for therapy.
FPN1 cycles as a monomer within the endocytic/plasma membrane compartment and responds to its physiological inhibitor, Hepc (show HAMP ELISA Kits), in both control and ferroportin disease (FD) cells. However, in FD, FPN1 fails to reach the cell surface when cells undergo high iron turnover.
These results suggest that FPN1 exports iron received from the iron chaperone PCBP2 (show PCBP2 ELISA Kits). Therefore, it was found that PCBP2 (show PCBP2 ELISA Kits) modulates cellular iron export, which is an important physiological process.
All these findings suggest that in erythroid cells FPN1 could be part of the signaling pathway through which the erythron communicates iron needs to expand the erythroid compartment regardless of systemic iron level.
Mir (show MLXIP ELISA Kits)-20a controls expression of the iron exporter ferroportin (FPN1) by binding to highly conserved target sites in its 3'-untranslated region. Expression of miR (show MLXIP ELISA Kits)-20a is inversely correlated to FPN1 in lung cancer.
The concentration of functional membrane-associated ferroportin is controlled by its ligand, the iron-regulatory hormone hepcidin (show HAMP ELISA Kits), and fine-tuned by regulatory mechanisms serving iron homeostasis, oxygen utilization, host defense, and erythropoiesis.
Low hepcidin (show HAMP ELISA Kits) and high ferroportin expression by erythroblasts and macrophages were seen in iron deficiency anemia, while the opposite was true in anemia of chronic disorders.
Erythroblasts from Beta-thalassemia patients showed a significantly reduced expression of total MTP1 protein.
Several family members had hemochromatosis (show HFE ELISA Kits) and hyperferritinemia associated with a SLC40A1 deletion in exon 5(485_487delTTG) resulting in the deletion of a valine residue (p.V162del). This is the 1st Spanish family reported with this European mutation.
TLR4 (show TLR4 ELISA Kits) dependent macrophage signaling is controlled via hepcidin (show HAMP ELISA Kits)-ferroportin1 axis by influencing TLR4 (show TLR4 ELISA Kits)-lipid raft interactions
Fasting upregulates Fpn1 expression in spleen and peritoneal macrophages, probably via a ghrelin (show GHRL ELISA Kits)/GHSR1a/MAPK (show MAPK1 ELISA Kits) signaling pathway.
Expression of Hepcidin (show HAMP ELISA Kits) and Ferroportin in the Placenta, and Ferritin (show FTL ELISA Kits) and Transferrin Receptor 1 (show TFR ELISA Kits) Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes
findings show that ferroportin expression by macrophages at the site of injury represents a requirement for appropriate activation of myogenic precursors and eventual healing of injured skeletal muscle
The results suggest that physiologic hepcidin (show HAMP ELISA Kits) levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells.
In Angiotensin II treated mice, duodenal divalent metal transporter-1 (show SLC11A2 ELISA Kits) and ferroportin expression levels were increased and hepatic hepcidin (show HAMP ELISA Kits) mRNA expression and serum hepcidin (show HAMP ELISA Kits) concentration were reduced.
Mice infected with Salmonella typhimurium have increased duodenal expression of the iron exporter ferroportin-1, consistent with increased uptake of dietary iron.
Results suggest that reduction in ferroportin levels in Alzheimer's disease brains are likely associated with cerebral ischaemia, inflammation, loss of neurons due to protein misfolding, senile plaque formation and possibly ageing process itself
Oral iron failed to be utilized by Fpn-KO mice and was retained in enterocytes, irrespective of the iron source. Ferroportin-dependent efflux from enterocytes controls duodenal iron absorption.
Genetic interactions between Cp, Mon1a (show MON1A ELISA Kits), and the Slc40a1 locus are involved in iron metabolism.
Hypoxia signal, stimulated erythropoietin (show EPO ELISA Kits), which affected iron absorption by stabilizing duodenal ferroportin.
The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).
, iron-regulated transporter
, solute carrier family 39 (iron-regulated transporter), member 1
, solute carrier family 40 member 1
, solute carrier family 40 (iron-regulated transporter), member 1
, solute carrier family 40 member 1-like
, iron regulated gene 1
, putative ferroportin 1 variant IIIB
, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
, SLC11A3 iron transporter
, ferroportin 1
, iron-regulated transporter 1
, metal transporter protein 1
, metal transporting protein 1
, cell adhesion regulator