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anti-Human STK4 Antibodies:
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Human Polyclonal STK4 Primary Antibody for IHC, IP - ABIN258128
Park, Kang, Lee, Zhang, Kim, Beers, Lim, Avruch, Kim, Lee: Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. in The Journal of biological chemistry 2010
Show all 2 Pubmed References
Human Polyclonal STK4 Primary Antibody for ICC, IF - ABIN4356627
Babel, Barderas, Diaz-Uriarte, Moreno, Suarez, Fernandez-Aceñero, Salazar, Capellá, Casal: Identification of MST1/STK4 and SULF1 proteins as autoantibody targets for the diagnosis of colorectal cancer by using phage microarrays. in Molecular & cellular proteomics : MCP 2011
TNFAIP8 (show TNFAIP8 Antibodies) regulates Hippo (MST1 (show MST1 Antibodies)/2) signaling through its interaction with LATS1 (show LATS1 Antibodies).
Data suggest that Hippo (MST1 (show MST1 Antibodies)/2 protein kinases) - Yes associated protein 1 (YAP (show YAP1 Antibodies)) pathway involved in carcinogenesis of pancreatic cancer and in the inhibition effect of stiehopus japonieus acidic mucopolysaccharide (SJAMP) to the proliferation of pancreatic cancer cell.
our results identified that mammalian sterile 20-like kinase 1 is a novel downstream target of pyruvate kinase M2, and knockdown of pyruvate kinase M2 contributes apoptosis via promoting nuclear translocation of mammalian sterile 20-like kinase 1 by enhancing Caspase-3 (show CASP3 Antibodies)-dependent cleavage.
H-ras (show HRAS Antibodies), via an Erk (show EPHB2 Antibodies)-dependent mechanism, downregulates Mst1 (show MST1 Antibodies)/Mst2 (show STK3 Antibodies) activity by inducing the formation of inactive Mst1 (show MST1 Antibodies)/Mst2 (show STK3 Antibodies) heterodimers.
Mst1 (show MST1 Antibodies) as a novel physiological negative regulator of IRF3 (show IRF3 Antibodies) activation provides mechanistic insights into innate antiviral defense and potential antiviral prevention strategies.
Data indicate that two siblings with a serine/threonine kinase 4 (STK4) mutation with features of autosomal recessive (AR) hyperimmunoglobulin E syndrome and autoimmune cytopenias.
STK4 was reduced in macrophages from human hepatoma patients and was inversely associated with the levels of IRAK1, IL-6, and phospho-p65 or phospho-STAT3. Serum STK4 levels were specifically decreased in HCC patients with high levels of IL-6.
The MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis.
the kinase Mst1 (show MST1 Antibodies) controls selective CCR7 (show CCR7 Antibodies)-dependent functions in human mature dendritic cells.
Genetic inactivation of STK4 restores YAP1 (show YAP1 Antibodies) levels, triggering cell death in hematologic malignancies.
Mst1 (show MST1 Antibodies) deficiency promotes post-traumatic spinal motor neuron survival via enhancement of autophagy flux.
mammalian sterile 20-like kinase 1 (Mst1) knockout abolished the protective effects of Luteolin administration in a mouse model of myocardial infarction.
Studies indicate that Hippo (Hpo (show GFER Antibodies); MST1 (show MST1 Antibodies)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Data (including data from studies in knockout/transgenic mice) suggest Mst1 (show MST1 Antibodies) has functional roles in cytotoxic T-lymphocytes and in inhibition of tumor progression/size of T-cell lymphoma; Mst1 (show MST1 Antibodies) may be involved in tumor immunity/immunologic surveillance.
the TLR-Mst1 (show MST1 Antibodies)-Mst2 (show STK3 Antibodies)-Rac (show AKT1 Antibodies) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
Macrophage-specific Stk4 deletion resulted in chronic inflammation, liver fibrosis, and hepatomas in mice exposed to liver insult.
STK4 is a novel candidate biomarker for early stage pancreatic cancer.
Phosphorylation of LC3 (show MAP1LC3A Antibodies) by the STK3 (show PKN1 Antibodies) and STK4 is essential for autophagy.
These results identify MST2 (show STK3 Antibodies), not MST1 (show MST1 Antibodies), as a critical regulator of caspase (show CASP3 Antibodies)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
Mst1 (show MST1 Antibodies)/2 regulate placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and Mst1 (show MST1 Antibodies)/2 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners.
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
, STE20-like kinase MST1
, dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
, kinase responsive to stress 2
, mammalian STE20-like protein kinase 1
, mammalian sterile 20-like 1
, serine/threonine-protein kinase 4
, serine/threonine-protein kinase Krs-2
, Yeast Sps1/Ste20-related kinase 3
, sterile 20-like kinase 1