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Sk1 and Sk2 (show KCNN2 ELISA Kits) are not redundant in biological function and are essential for diverse physiological functions in Drosophila
SPHK/phyto-S1P (show MBTPS1 ELISA Kits) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.
Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.
Melatonin administration significantly inhibited those changes and induced a decreased immunoreactivity for rabbit hemorrhagic disease virus VP60 antigen in the liver. Results obtained indicate that the SphK1/S1P (show MBTPS1 ELISA Kits) system activates in parallel to viral replication and the inflammatory process induced by the virus.
SK1 (show KCNN1 ELISA Kits) activation is renoprotective via induction of autophagy in the fibrotic process
High SPHK1 expression is associated with ovarian Cancer.
Sphingosine kinase 1 is involved in papillary thyroid carcinoma development and progression and can serve as a potential biomarker predictive of lymph node metastasis.
High SPHK1 expression is associated with hepatocellular carcinoma.
we identified sphingosine kinase 1 (SPHK1) as a novel target of miR (show MLXIP ELISA Kits)-506, the expression of which inhibited the SPHK1/Akt (show AKT1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) signaling pathway, which is activated in pancreatic cancer. High SPHK1 expression was significantly associated with poor survival in a large cohort of pancreatic cancer specimens.
Inhibition of SPHK1 in human acute myeloid leukemia (show BCL11A ELISA Kits) cells induces MCL1 (show MCL1 ELISA Kits) degradation and caspase (show CASP3 ELISA Kits)-dependent cell death.
The analysis suggests that the catalytic function and regulation of SPHK1 and SPHK2 (show SPHK2 ELISA Kits) might be dependent on their conformational mobility. (Review)
our data suggest that SphK1 modulates the expression of EMT (show ITK ELISA Kits)-related markers and cell migration by regulating the expression of p-FAK (show PTK2 ELISA Kits) in CRC (show CALR ELISA Kits) cells. Thus, SphK1 may play a functional role in mediating the EMT (show ITK ELISA Kits) process in CRC (show CALR ELISA Kits).
These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.
By simulating therapeutic strategies that target multiple nodes of the pathway such as Raf and SphK1, we conclude that combination therapy should be much more effective in blocking VEGF signaling to EKR1/2. The model has important implications for interventions that target signaling pathways in angiogenesis relevant to cancer, vascular diseases, and wound healing.
SK1 activation is renoprotective via induction of autophagy in the fibrotic process
donor islets from mice deficient in Sphk1 KO contain a reduced number of resident intraislet vascular endothelial cells. The main product of Sphk1, sphingosine-1-phosphate, controls the migration of intraislet endothelial cells in vitro. In vivo, Sphk1 knockout islets have an impaired ability to cure diabetes compared with wild-type controls.
Sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis by stimulation of proliferation of cancer cells.
Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (show S1PR1 ELISA Kits) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.
These findings suggest that the inhibitory effect of these plant extracts on the activation of AGEs/RAGE (show AGER ELISA Kits)/SphK1 signaling pathway in db/db (show LEPR ELISA Kits) diabetic mice kidney is a novel mechanism by which they exert renoprotective effects in diabetic nephropathy.
Keratinocyte-specific deletion of Traf2 (show TRAF2 ELISA Kits), but not Sphk1 deficiency, disrupted TNF (show TNF ELISA Kits) mediated NF-kappaB (show NFKB1 ELISA Kits) and MAP kinase (show MAPK1 ELISA Kits) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.
SphK1 dependent PKC-delta (show PKCd ELISA Kits) activation plays an important role in promoting NF-kappaB (show NFKB1 ELISA Kits) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (show PKCd ELISA Kits) activation might be a potential therapeutic strategy for this disease.
Inhibition of SphK1 ameliorates drug-induced acute liver failure by reducing HMGB1 (show HMGB1 ELISA Kits) cytoplasmic translocation in liver cells.
Collectively, our results demonstrate that PF-543 exerts potent anti-CRC (show SCRIB ELISA Kits) activity in vitro and in vivo.
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, sphingosine kinase 1
, sphingosine kinase I
, SK 1
, SPK 1