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WNT Signaling

Wnts are a class of evolutionarily-conserved, lipid-modified glycoproteins that play a pivotal role in development and homeostasis through a number of different paracrine and autocrine signal-transduction pathways. During early development, Wnt signaling plays a major role in axon guidance, cell polarity, and body axis specification.

Extracellular Wnts bind a variety of different receptors, and initiate signaling in several distinct pathways. Receptors include seven-pass transmembrane Frizzleds and receptor tyrosine kinases ROR and Ryk.

Wnt signaling pathways can result in changes to gene transcription. For example, in the canonical β-catenin signaling pathway Wnt signaling prevents destruction of the transcriptional regulator β-catenin. Wnt signaling can also prompt morphological changes to cellular structure e.g., the non-canonical planar cell polarity pathway induces a kinase cascade that results in reorganization of actin, a core component of the cytoskeleton.

Antagonists

DKK1 (Dickkopf Homolog 1 (Xenopus Laevis)):

The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010].   More...
Antigens in this category:
DKK4 (Dickkopf Homolog 4 (Xenopus Laevis)): DKK4 antibodies DKK4 ELISA Kits DKK4 Proteins
KREMEN1 (Kringle Containing Transmembrane Protein 1): KREMEN1 antibodies KREMEN1 ELISA Kits KREMEN1 Proteins
KREMEN2 (Kringle Containing Transmembrane Protein 2): KREMEN2 antibodies KREMEN2 ELISA Kits KREMEN2 Proteins
DKK2 (Dickkopf 2 Homolog (Xenopus Laevis)): DKK2 antibodies DKK2 ELISA Kits DKK2 Proteins
FRZB (Frizzled-Related Protein): FRZB antibodies FRZB ELISA Kits FRZB Proteins
IGFBP4 (Insulin-Like Growth Factor Binding Protein 4): IGFBP4 antibodies IGFBP4 ELISA Kits IGFBP4 Proteins
IGFBP5 (Insulin-Like Growth Factor Binding Protein 5): IGFBP5 antibodies IGFBP5 ELISA Kits IGFBP5 Proteins
IGFBP6 (Insulin-Like Growth Factor Binding Protein 6): IGFBP6 antibodies IGFBP6 ELISA Kits IGFBP6 Proteins
SFRP1 (Secreted Frizzled-Related Protein 1): SFRP1 antibodies SFRP1 ELISA Kits SFRP1 Proteins
SFRP2 (Secreted Frizzled-Related Protein 2): SFRP2 antibodies SFRP2 ELISA Kits SFRP2 Proteins
SFRP4 (Secreted Frizzled-Related Protein 4): SFRP4 antibodies SFRP4 ELISA Kits SFRP4 Proteins
SFRP5 (Secreted Frizzled-Related Protein 5): SFRP5 antibodies SFRP5 ELISA Kits SFRP5 Proteins
WIF1 (WNT Inhibitory Factor 1): WIF1 antibodies WIF1 ELISA Kits WIF1 Proteins
ZNRF3 (Zinc and Ring Finger Protein 3): ZNRF3 antibodies   ZNRF3 Proteins

beta-Catenin Pathway

APC - Adenomatous Polyposis Coli

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated...   More...

CSNK1A1 (Casein Kinase 1, alpha 1):

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member...   More...

TCF7L1 (Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box)):

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell...   More...

TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box)):

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq,...   More...
Antigens in this category:
AES (Amino-terminal Enhancer of Split): AES antibodies AES ELISA Kits AES Proteins
AXIN1 (Axin 1): AXIN1 antibodies AXIN1 ELISA Kits AXIN1 Proteins
CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa): CTNNB1 antibodies CTNNB1 ELISA Kits CTNNB1 Proteins
DVL1 (Dishevelled, Dsh Homolog 1 (Drosophila)): DVL1 antibodies DVL1 ELISA Kits DVL1 Proteins
GSK3a - GSK3 alpha: GSK3a antibodies GSK3a ELISA Kits GSK3a Proteins
GSK3b - GSK3 beta: GSK3b antibodies    
LLGL1 (Lethal Giant Larvae Homolog 1 (Drosophila)): LLGL1 antibodies LLGL1 ELISA Kits LLGL1 Proteins
LLGL2 (Lethal Giant Larvae Homolog 2 (Drosophila)): LLGL2 antibodies LLGL2 ELISA Kits LLGL2 Proteins
LEF1 (Lymphoid Enhancer-Binding Factor 1): LEF1 antibodies LEF1 ELISA Kits LEF1 Proteins
PYGO1 (Pygopus Homolog 1 (Drosophila)): PYGO1 antibodies   PYGO1 Proteins
PYGO2 (Pygopus Homolog 2 (Drosophila)): PYGO2 antibodies   PYGO2 Proteins
TCF3 (Transcription Factor 3): TCF3 antibodies    
TCF4 (Transcription Factor 4): TCF4 antibodies TCF4 ELISA Kits TCF4 Proteins
TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box)): TCF7 antibodies TCF7 ELISA Kits TCF7 Proteins
TLE1 (Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila)): TLE1 antibodies   TLE1 Proteins
TLE2 (Transducin-Like Enhancer of Split 2 (E(sp1) Homolog, Drosophila)): TLE2 antibodies   TLE2 Proteins
TLE4 (Transducin-Like Enhancer of Split 4 (E(sp1) Homolog, Drosophila)): TLE4 antibodies    
TLE6 (Transducin-Like Enhancer of Split 6 (E(sp1) Homolog, Drosophila)): TLE6 antibodies   TLE6 Proteins

Calcium Pathway

CAMK2B (Calcium/calmodulin-Dependent Protein Kinase (CaM Kinase) II beta):

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that...   More...

CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha):

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is...   More...

CDC42 - Cell Division Cycle 42 (GTP Binding Protein, 25kDa)

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to...   More...

PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isozyme):

catalytic subunit of Calcineurin (CaN), ubiquitously expressed Ca2+/CaM-dependent protein phosphatase\; mediates activities of transcription factors and ion channels\; involved in regulation of T-cell activation [RGD, Feb 2006].   More...
Antigens in this category:
CAMK2D (Calcium/calmodulin-Dependent Protein Kinase II delta): CAMK2D antibodies CAMK2D ELISA Kits CAMK2D Proteins
CAMK2G (Calcium/calmodulin-Dependent Protein Kinase II gamma): CAMK2G antibodies CAMK2G ELISA Kits CAMK2G Proteins
CALM1 - Calmodulin 1 (Phosphorylase Kinase, Delta): CALM1 antibodies CALM1 ELISA Kits CALM1 Proteins
PLCb2 - Phospholipase C beta 2: PLCb2 antibodies PLCb2 ELISA Kits PLCb2 Proteins
PLCb4 - Phospholipase C beta 4: PLCb4 antibodies PLCb4 ELISA Kits  
PLCd3 - Phospholipase C delta 3: PLCd3 antibodies PLCd3 ELISA Kits PLCd3 Proteins
PLCG2 - Phospholipase C gamma 2: PLCG2 antibodies PLCG2 ELISA Kits PLCG2 Proteins
PLCB1 - Phospholipase C beta 1: PLCB1 antibodies PLCB1 ELISA Kits PLCB1 Proteins
PLCB3 (phospholipase C, beta 3 (Phosphatidylinositol-Specific)): PLCB3 antibodies PLCB3 ELISA Kits  
PLCD1 (phospholipase C, delta 1): PLCD1 antibodies PLCD1 ELISA Kits PLCD1 Proteins
PLCG1 - Phospholipase C gamma 1: PLCG1 antibodies PLCG1 ELISA Kits PLCG1 Proteins
PKCa - PKC alpha: PKCa antibodies PKCa ELISA Kits PKCa Proteins
PRKCB - PKC beta: PRKCB antibodies PRKCB ELISA Kits PRKCB Proteins
PRKCG - PKC gamma: PRKCG antibodies PRKCG ELISA Kits PRKCG Proteins
PPP3CB (Protein Phosphatase 3, Catalytic Subunit, beta Isozyme): PPP3CB antibodies PPP3CB ELISA Kits PPP3CB Proteins
PPP3CC (Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme): PPP3CC antibodies PPP3CC ELISA Kits PPP3CC Proteins
PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha): PPP3R1 antibodies PPP3R1 ELISA Kits PPP3R1 Proteins

Co-Receptors

LRP5 (Low Density Lipoprotein Receptor-Related Protein 5):

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role...   More...

LRP6 (Low Density Lipoprotein Receptor-Related Protein 6):

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through...   More...

Frizzleds

Fzd1 - FZD1

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if...   More...

FZD2 - Frizzled Family Receptor 2

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and...   More...
Antigens in this category:
LOC100313610 - Frizzled 5/8 Protein Receptor: LOC100313610 antibodies    
FZD10 (Frizzled Family Receptor 10): FZD10 antibodies FZD10 ELISA Kits FZD10 Proteins
FZD3 (Frizzled Family Receptor 3): FZD3 antibodies FZD3 ELISA Kits FZD3 Proteins
FZD4 (Frizzled Family Receptor 4): FZD4 antibodies FZD4 ELISA Kits FZD4 Proteins
FZD6 (Frizzled Family Receptor 6): FZD6 antibodies FZD6 ELISA Kits FZD6 Proteins
FZD7 (Frizzled Family Receptor 7): FZD7 antibodies    
FZD8 (Frizzled Family Receptor 8): FZD8 antibodies FZD8 ELISA Kits FZD8 Proteins
GPBAR1 (G Protein-Coupled Bile Acid Receptor 1): GPBAR1 antibodies GPBAR1 ELISA Kits GPBAR1 Proteins

PCP Pathway

DAAM1 (Dishevelled Associated Activator of Morphogenesis 1):

Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture,...   More...

JUN - C-JUN

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul...   More...

RHO - Rhodopsin

Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein...   More...
Antigens in this category:
MAPK10 (Mitogen-Activated Protein Kinase 10): MAPK10 antibodies MAPK10 ELISA Kits MAPK10 Proteins
MAPK8 - JNK: MAPK8 antibodies MAPK8 ELISA Kits MAPK8 Proteins
MAPK9 (Mitogen-Activated Protein Kinase 9): MAPK9 antibodies MAPK9 ELISA Kits MAPK9 Proteins
NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive): NFAT5 antibodies NFAT5 ELISA Kits NFAT5 Proteins
NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1): NFATC1 antibodies NFATC1 ELISA Kits NFATC1 Proteins
NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2): NFAT1 antibodies NFAT1 ELISA Kits NFAT1 Proteins
NFATC3 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3): NFATC3 antibodies NFATC3 ELISA Kits NFATC3 Proteins
NFATC4 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4): NFATC4 antibodies NFATC4 ELISA Kits NFATC4 Proteins
RHOA (Ras Homolog Gene Family, Member A): RHOA antibodies RHOA ELISA Kits RHOA Proteins
RHOC (Ras Homolog Gene Family, Member C): RHOC antibodies RHOC ELISA Kits RHOC Proteins
RHO (rho): RHO antibodies RHO ELISA Kits  
ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1): ROCK1 antibodies ROCK1 ELISA Kits ROCK1 Proteins
ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2): ROCK2 antibodies ROCK2 ELISA Kits ROCK2 Proteins

Receptor Tyrosine Kinases

ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1):

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed...   More...

ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2):

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by...   More...

RYK (RYK Receptor-Like Tyrosine Kinase):

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that...   More...

WNTs

WNT2 (Wingless-Type MMTV Integration Site Family Member 2):

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided...   More...

WNT1 (Wingless-Type MMTV Integration Site Family, Member 1):

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be...   More...
Antigens in this category:
WNT3A - Wingless-Related MMTV Integration Site 3A: WNT3A antibodies   WNT3A Proteins
WNT10A (Wingless-Type MMTV Integration Site Family, Member 10A): WNT10A antibodies WNT10A ELISA Kits WNT10A Proteins
WNT10B (Wingless-Type MMTV Integration Site Family, Member 10B): WNT10B antibodies WNT10B ELISA Kits WNT10B Proteins
WNT16 (Wingless-Type MMTV Integration Site Family, Member 16): WNT16 antibodies WNT16 ELISA Kits WNT16 Proteins
WNT2B (Wingless-Type MMTV Integration Site Family, Member 2B): WNT2B antibodies WNT2B ELISA Kits WNT2B Proteins
WNT3 (Wingless-Type MMTV Integration Site Family, Member 3): WNT3 antibodies WNT3 ELISA Kits WNT3 Proteins
WNT3A (Wingless-Type MMTV Integration Site Family, Member 3A): WNT3A antibodies WNT3A ELISA Kits WNT3A Proteins
WNT4 (Wingless-Type MMTV Integration Site Family, Member 4): WNT4 antibodies WNT4 ELISA Kits WNT4 Proteins
WNT5A (Wingless-Type MMTV Integration Site Family, Member 5A): WNT5A antibodies WNT5A ELISA Kits WNT5A Proteins
WNT6 (Wingless-Type MMTV Integration Site Family, Member 6): WNT6 antibodies WNT6 ELISA Kits WNT6 Proteins
WNT7A (Wingless-Type MMTV Integration Site Family, Member 7A): WNT7A antibodies WNT7A ELISA Kits WNT7A Proteins
WNT7B (Wingless-Type MMTV Integration Site Family, Member 7B): WNT7B antibodies WNT7B ELISA Kits WNT7B Proteins
WNT8A (Wingless-Type MMTV Integration Site Family, Member 8A): WNT8A antibodies WNT8A ELISA Kits WNT8A Proteins
WNT8B - Wingless-Type MMTV Integration Site Family, Member 8B: WNT8B antibodies    
WNT9A (Wingless-Type MMTV Integration Site Family, Member 9A): WNT9A antibodies WNT9A ELISA Kits WNT9A Proteins
WNT9B (Wingless-Type MMTV Integration Site Family, Member 9B): WNT9B antibodies WNT9B ELISA Kits WNT9B Proteins