anti-Mouse (Murine) LRP6 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended LRP6 Antibody (supplied by: Log in to see )

Antigen
Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Antibodies
  • lrp6-A
  • Xlrp6
  • adcad2
  • lrp6
  • LRP6
  • ADCAD2
  • C030016K15Rik
  • Cd
  • Gw
  • low density lipoprotein receptor-related protein 6
  • low-density lipoprotein receptor-related protein 6
  • LRP6
  • lrp6-A
  • lrp6-b
  • lrp6
  • Lrp6
Epitope
AA 1470-1520, pSer1490
23
14
14
13
8
8
6
5
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
106
24
8
3
1
1
1
1
1
1
Host
Rabbit
62
28
16
1
Clonality
Polyclonal
Conjugate
This LRP6 antibody is un-conjugated
4
4
4
4
4
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
40
36
33
30
21
13
12
4
3
3
3
1
1
Options
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Catalog No. ABIN743558
$ 317.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN743567 IHC (p) HRP Rabbit IgG AA 1470-1520, pSer1490 Log in to see Polyclonal
1 ABIN743560 IHC (p) Biotin Rabbit IgG AA 1470-1520, pSer1490 Log in to see Polyclonal
1 ABIN1736559 IHC (p) ELISA Goat Internal Region Log in to see Polyclonal

General

Antigen Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Antibodies
Epitope AA 1470-1520, pSer1490
(23), (14), (14), (13), (8), (8), (6), (5), (2), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(106), (24), (8), (3), (1), (1), (1), (1), (1), (1)
Host Rabbit
(62), (28), (16), (1)
Clonality
Polyclonal
Conjugate This LRP6 antibody is un-conjugated
(4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(40), (36), (33), (30), (21), (13), (12), (4), (3), (3), (3), (1), (1)
Pubmed 2 references available
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Product Details anti-LRP6 Antibody

Target Details LRP6 Application Details Handling References for anti-LRP6 antibody (ABIN743558) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490
Isotype IgG

Target Details LRP6

Product Details anti-LRP6 Antibody Application Details Handling References for anti-LRP6 antibody (ABIN743558) Images back to top
Antigen
Alternative Name Lrp6 (LRP6 Antibody Abstract)
Background

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

Subcellular location: Cytoplasm

Synonyms: ADCAD2, Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6

Gene ID 4040
UniProt O75581
Research Area Stem Cells, Wnt
Pathways WNT Signaling, Tube Formation

Application Details

Product Details anti-LRP6 Antibody Target Details LRP6 Handling References for anti-LRP6 antibody (ABIN743558) Images back to top
Application Notes IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-LRP6 Antibody Target Details LRP6 Application Details References for anti-LRP6 antibody (ABIN743558) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-LRP6 antibody (ABIN743558)

Product Details anti-LRP6 Antibody Target Details LRP6 Application Details Handling Images back to top
Product cited in:

Boone, Arend, Johnston, Cooper, Gilchrist, Oelschlager, Grizzle, McGwin, Gangrade, Straughn, Buchsbaum: "Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 96, Issue 2, pp. 249-59, 2016

Chen, Xu, Ye, Li, Gong, Zhang, Wu, Jia, Liu, Chen, Yang, Tang, Zhu, Ge, Zou: "Urotensin II inhibited the proliferation of cardiac side population cells in mice during pressure overload by JNK-LRP6 signalling." in: Journal of cellular and molecular medicine, Vol. 18, Issue 5, pp. 852-62, 2014

Images

Product Details anti-LRP6 Antibody Target Details LRP6 Application Details Handling References for anti-LRP6 antibody (ABIN743558) back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (AA 1470-1520), (pSer1490) antibody (ABIN743558) Paraformaldehyde-fixed, paraffin embedded rat stomach; Antigen retrieval by boiling i...