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Human SFRP5 ELISA Kit for Sandwich ELISA - ABIN457072
Qu, Wang, Deng, Wei, Deng: Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population. in PLoS ONE 2014
Show all 3 references for ABIN457072
Mouse (Murine) SFRP5 ELISA Kit for Sandwich ELISA - ABIN426019
Hu, Li, Yang, Luo, Ran, Liu, Xiong, Liu, Yang: Circulating Sfrp5 is a signature of obesity-related metabolic disorders and is regulated by glucose and liraglutide in humans. in The Journal of clinical endocrinology and metabolism 2013
Show all 2 references for ABIN426019
note an increase in BMP ligand expression in Sfrp1a/5 depleted embryos, a phenotype similar to that seen in embryos with inhibited BMP signaling
Sfrp5 inhibits both canonical and non-canonical Wnt (show WNT2 ELISA Kits) signaling during embryonic and endodermal development
propose that XsFRP5 exerts an early regulatory function in the specification of the ventral pancreas, as well as a late function in controlling stomach size via inhibition of Wnt (show WNT2 ELISA Kits) signalling
Report reduced hepatic SFRP5 expression in morbidly women with NAFLD (show TSC2 ELISA Kits).
Data suggest that serum SFRP5 levels are up-regulated in subjects with newly diagnosed type 2 diabetes as compared to prediabetic or control subjects; subjects were matched for obesity/overweight/body mass index.
Serum WISP2 (show WISP2 ELISA Kits) correlated directly with fatty acid binding protein 4. Serum SFRP5 did not differ between obese (n=32) vs. nonobese (n=25) PCOS women, but reference women had lower SFRP5 (p<5x10(-6) as compared to both PCOS groups).
Sfrp5 represents a candidate for a mature adipocyte marker gene.
The wnt5a (show WNT5A ELISA Kits)/sFRP5 system is altered in human sepsis and might therefore be of interest for future studies on molecular pathophysiology of this common human disease.
Serum SFRP5 is regulated by weight status and seems to be correlated with metabolic disorders in children.
We were able to show a significant association of sFRP5 with both total abdominal and subcutaneous fat. The association signal was only seen in obese males in which the minor allele of rs7072751 explains 1.8 % of variance in total abdominal fat.
Aberrant methylation of APC (show APC ELISA Kits) gene was statistically significant associated with age over 50, DDK3 with male, SFRP4 (show SFRP4 ELISA Kits), WIF1 (show WIF1 ELISA Kits), and WNT5a (show WNT5A ELISA Kits) with increasing tumor stage SFRP4 (show SFRP4 ELISA Kits) and WIF1 (show WIF1 ELISA Kits) with tumor differentiation and SFRP2 (show SFRP2 ELISA Kits) and SFRP5 with histological type
SFRP5 and WNT5A (show WNT5A ELISA Kits) comprise a balanced duo (show KALRN ELISA Kits) that may regulate metabolic homeostasis in prepubertal children.
Secreted frizzled-related protein 5 suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through down-regulation of c-Jun N-terminal kinase.
MicroRNA-124 regulates cell specification in the cochlea through modulation of Sfrp4 (show SFRP4 ELISA Kits) and Sfrp5.
although high sFRP5 expression inhibits B-lymphopoiesis in vivo, physiologically, it contributes to the preservation of very primitive lymphopoietic progenitors, including hematopoietic stem cells, under high estrogen levels
A role for SFRP5 in glucose metabolism and pancreatic beta-cell function indicates that the use of an anti-SFRP5 mAb as a potential approach to treat type 2 diabetes.
Sfrp5 mRNA expression and protein secretion depend on the differentiation of adipocytes. The dysregulation of Sfrp5 expression and secretion is directly correlated with insulin (show INS ELISA Kits) resistance.
We propose that Ift88 (show IFT88 ELISA Kits) and primary cilia regulate expression of Sfrp5 and Wnt (show WNT2 ELISA Kits) signaling pathways in growth plate via regulation of Ihh (show IHH ELISA Kits) signaling.
early progeny of Sox2 (show SOX2 ELISA Kits)-positive stem cells transiently expressed the Wnt (show WNT2 ELISA Kits) inhibitor Sfrp5
SFRP5 inhibits WNT (show WNT2 ELISA Kits) signaling to suppress oxidative metabolism and stimulate adipocyte growth during obesity.
data show Sfrp5 is an anti-inflammatory adipokine whose expression is perturbed in models of obesity and type 2 diabetes; in obesity, Sfrp5 secretion exerts salutary effects on metabolic dysfunction by controlling adipose tissue inflammatory cells
Here we report that the Secreted frizzled-related protein 5 (Sfrp5) gene, which encodes a secreted factor that can antagonize Wnt (show WNT2 ELISA Kits) signaling, is expressed in the AVE and foregut endoderm during early mouse development
Data show that expression of both Sfrp2 (show SFRP2 ELISA Kits) and Sfrp5 during development of the Mullerian duct in male (XY) and female (XX) mouse embryos is dynamic and sexually dimorphic.
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.
, secreted frizzled-related sequence protein 5
, frizzled-related protein 1b
, secreted apoptosis related protein 3
, secreted apoptosis-related protein 3
, secreted frizzled-related protein 5