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Human WNT3 Protein expressed in Wheat germ - ABIN1325359
Kraushar, Viljetic, Wijeratne, Thompson, Jiao, Pike, Medvedeva, Groszer, Kiledjian, Hart, Rasin: Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Data suggest that Wnt3 (show WNT3A Proteins), Wnt3a (show WNT3A Proteins), and Wnt8a (show WNT8A Proteins) bind to their respective receptors (Fz8 (show FZD2 Proteins), Lrp6 (show LRP5 Proteins), and Lypd6 (show LYPD6 Proteins)) in ordered plasma membrane environments; ordered plasma membrane environments appear to be essential for binding of Wnt (show WNT2 Proteins) proteins to their receptor complexes and stimulation of downstream signaling activity.
Wnt3 (show WNT3A Proteins) is associated with cholesterol-dependent domains
WNT3 (show WNT3A Proteins) involvement in human bladder exstrophy and cloaca development in zebrafish
Study demonstrates that Wnt3 (show WNT3A Proteins) regulates cerebellum development during embryogenesis using zebrafish wnt3 (show WNT3A Proteins) transgenics with either tissue-specific expression of an EGFP reporter or a functionally active fusion protein, Wnt3EGFP.
We have identified canonical Wnt (show WNT2 Proteins) signaling as a novel pathway, that is required for proper formation of the mid-diencephalic organizer and consequently for the development of the major relay station of the brain - the thalamus.
Wnt3 (show WNT3A Proteins) participates in processes such as forebrain compartmentalization and regulation of tectal wiring topography by retinal ganglia axons.
Study indicates essential roles for Wnt2 (show WNT2 Proteins) and Wnt3 in chronic restraint stress-induced depression-like behaviors and antidepressant.
these results therefore highlight an unanticipated role for p53 (show TP53 Proteins) family proteins in a regulatory network that integrates essential Wnt (show WNT2 Proteins)-Tcf (show HNF4A Proteins) and nodal-Smad (show SMAD1 Proteins) inputs.
stem-cell membranes constitute a reservoir for Wnt (show WNT2 Proteins) proteins, while Frizzled receptor turnover and 'plasma membrane dilution' through cell division shape the epithelial Wnt3 gradient
timed secretion of wnt3 by ingrowing axons from the thalamus regulates the combinatorial composition of ribosomal proteins in developing neocortex. WNT3 further regulates the specificity of mRNA translation and development of neurons and oligodendrocytes.
this article shows that absence of Wnt3 in the posterior visceral endoderm leads to delayed formation of the primitive streak and that interplay between anterior and posterior visceral endoderm restricts the position of the primitive streak
Data indicate that functional Wnt3/beta-Catenin (show CTNNB1 Proteins) signaling is localized to the dorsal subventricular zone (SVZ) microdomain.
Wnt3 is part of a signaling loop that affects homeostasis of intestinal stem and Paneth cells in mice.
Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice
canonical Wnt (show WNT2 Proteins) signaling regulates CXCL12 (show CXCL12 Proteins) gene expression at the transcriptional level
Wnt-3a (show WNT3A Proteins) and Wnt-3 factors signal through the canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway to regulate different aspects of spinal cord neural progenitor development.
Wnt3 is associated with cholesterol-dependent domains
analysis of WNT3 expression in CLL patients demonstrated that (i) untreated patients with more aggressive disease (with a notable exception of patients with 11q deletion) express less WNT3, (ii) WNT3 declines with disease progression in a significant proportion of patients and (iii) low WNT3 was identified as a strong independent marker indicating shorter treatment-free survival in CLL patients with IGHV mutation.
PRKX (show PRKX Proteins), WNT3 and WNT16 (show WNT16 Proteins) genes, belonging to the WNT (show WNT2 Proteins) signaling pathway, are involved in the tumorigenic process of nodular basal cell carcinoma
Two SNPs (rs3809857 and rs9890413) in the WNT3 gene were subjected to case-control and case-parent analysis
WNT3 and membrane-associated beta-catenin (show CTNNB1 Proteins) regulate trophectoderm lineage differentiation in human blastocysts.
WNT3 involvement in human bladder exstrophy and cloaca development in zebrafish
Genome association study shows a highly conserved 32 kb intergenic region containing regulatory elements between WNT3 and WNT9B (show WNT9B Proteins) in patients with classic bladder exstrophy.
mRNA level of WNT3 in hESCs correlates with their definitive ectoderm differentiation efficiency.
Data show that the WNT (show WNT2 Proteins)/beta-CATENIN (show CTNNB1 Proteins) signaling cascade components, including WNT (show WNT2 Proteins) ligands WNT3 and WNT5A (show WNT5A Proteins), is crucial for early odontogenesis.
WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK (show MAPK1 Proteins) activation.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.
, wingless-type MMTV integration site family member 3
, wingless-type MMTV integration site family, member 3
, wingless-related MMTV integration site 3A
, proto-oncogene Wnt-3-like
, proto-oncogene Int-4
, proto-oncogene protein Wnt-3
, WNT-3 proto-oncogene protein
, proto-oncogene Int-4 homolog
, Wingless-type MMTV integration site 3, homolog
, wingless-related MMTV integration site 3
, Xwnt-3 region near C-terminus