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anti-Rat (Rattus) ZNRF3 Antibodies:
anti-Human ZNRF3 Antibodies:
anti-Mouse (Murine) ZNRF3 Antibodies:
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ZnRF3 negatively influences both the Wnt (show WNT2 Antibodies) and Hedgehog (show SHH Antibodies) proliferative pathways, and probably this way it negatively regulates cancer progression.
ZnRF3 negatively influences both the Wnt (show WNT2 Antibodies) and Hedgehog (show SHH Antibodies) proliferative pathways and probably this way it negatively regulates cancer progression
Report shows that miR (show MLXIP Antibodies)-146b participated in migration, invasion and chemoresistance in osteosarcoma via downregulation of ZNRF3.
Data indicate Dishevelled (DVL (show DVL2 Antibodies)) as a dual function adaptor to recruit negative regulators ZNRF3/RNF43 (show RNF43 Antibodies) to Wnt (show WNT2 Antibodies) receptors to ensure proper control of pathway activity.
ZNRF3 binds RSPO1 (show RSPO1 Antibodies) and LGR5 (show LGR5 Antibodies)-RSPO1 (show RSPO1 Antibodies) with micromolar affinity via RSPO1 (show RSPO1 Antibodies) furin (show FURIN Antibodies)-like 1 (Fu1) domain.
Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15 (show TBX15 Antibodies)/WARS2 (show WARS2 Antibodies), STAB1 (show STAB1 Antibodies), PIGC (show PIGC Antibodies), ZNRF3, GRB14 (show GRB14 Antibodies)
Signalling potency of R-spondin proteins depends on their ability to recruit ZNRF3 or RNF43 (show RNF43 Antibodies) via Fu1 into a complex with LGR receptors, which interact with Rspo (show RSPO1 Antibodies) via Fu2
ZNRF3 inhibits gastric cancer cell growth and promotes cell apoptosis by affecting the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)/TCF4 (show TCF4 Antibodies) signalling pathway.
study provides new mechanistic insights (show WNT2 Antibodies)into the regulation of Wnt receptor turnover, and reveals ZNRF3 as a tractable target for therapeutic exploration
Crystal structure confirming that Rspo (show RSPO1 Antibodies) proteins cross-link LGRs and ZNRF3 into a 2:2:2 complex.
data suggest that R-spondin enhances Wnt (show WNT2 Antibodies) signalling by inhibiting ZNRF3
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway.
, E3 ubiquitin-protein ligase ZNRF3
, RING finger protein 203
, novel C3HC4 type Zinc finger (ring finger)
, zinc/RING finger protein 3