anti-Activin A Receptor, Type IB (ACVR1B) Antibodies

ACVR1B encodes an activin A type IB receptor. Additionally we are shipping Activin A Receptor Type IB Proteins (29) and Activin A Receptor Type IB Kits (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACVR1B 11479 Q61271
ACVR1B 91 P36896
ACVR1B 29381 P80202
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Top anti-Activin A Receptor Type IB Antibodies at antibodies-online.com

Showing 10 out of 162 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, WB The anti-ACVR1B Pab (ABIN392231) is used in Western blot to detect ACVR1B in mouse kidney tissue lysate. Flow cytometric analysis of 293 cells using Activin A Receptor Type IB (ACVR1B) Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of ACVR1B staining in human lymph node formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of ACVR1B expression in HeLa (A), Jurkat (B), SP2/0 (C), H9C2 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from 293/mouse liver cells, using ACV1B Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using ACV1B Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated WB ACVR1B  western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the ACVR1B antibody detected the ACVR1B protein (arrow).(1?1000) 0.1 mL Log in to see 10 to 11 Days
$385.00
Details
Mouse Mouse Un-conjugated WB ACVR1B Antibody  western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the ACVR1B antibody detected the ACVR1B protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated FACS, WB The anti-ACVR1B Pab (ABIN392232) is used in Western blot to detect ACVR1B in Jurkat (1) and mouse kidney (2) tissue lysates. Flow cytometric analysis of 293 cells using Activin A Receptor Type IB (ACVR1B) Antibody (Center) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (50 ug of whole cell lysate) A: mouse brain 7.5% SDS PAGE antibody diluted at 1:1000 WB Image Sample (30 ug of whole cell lysate) A: SK-N-SH 7.5% SDS PAGE antibody diluted at 1:3000 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Log in to see Available
$181.73
Details

Top referenced anti-Activin A Receptor Type IB Antibodies

  1. Human Polyclonal Activin A Receptor Type IB Primary Antibody for ELISA, WB - ABIN544425 : Danila, Zhang, Zhou, Haidar, Klibanski: Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells. in The Journal of clinical endocrinology and metabolism 2002 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal Activin A Receptor Type IB Primary Antibody for ELISA, WB - ABIN544423 : Mukasa, Nomura, Tanaka, Tanaka, Nishi, Okabe, Goto, Yanase, Nawata: Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells. in Endocrinology 2003 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal Activin A Receptor Type IB Primary Antibody for PLA, ELISA - ABIN559768 : Zhu, Xu, Cuascut, Hall, Oxford: Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)

  4. Human Polyclonal Activin A Receptor Type IB Primary Antibody for WB - ABIN6136505 : Dong, Liu, Meng, Liu, Bi, Wu, Jin, Yao, Tang, Wang, Li, Zhang, Yu, Zhan, Chen, Ge, Yang, Li: Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination. in Scientific reports 2018 (PubMed)

  5. Human Polyclonal Activin A Receptor Type IB Primary Antibody for IF, IHC - ABIN6712409 : Yan, Zhang, Fang, Zhang, Wu, Jiang, Sun, Hu: MicroRNA-145 suppresses mouse granulosa cell proliferation by targeting activin receptor IB. in FEBS letters 2012 (PubMed)

  6. Human Monoclonal Activin A Receptor Type IB Primary Antibody for CyTOF, FACS - ABIN4899783 : Tengroth, Arebro, Larsson, Bachert, Georén, Cardell: Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps. in Scientific reports 2018 (PubMed)

More Antibodies against Activin A Receptor Type IB Interaction Partners

Mouse (Murine) Activin A Receptor, Type IB (ACVR1B) interaction partners

  1. Our study provided experimental and clinical evidence for the involvement of activin A and ALK4 in the pathophysiology of atrial fibrosis and atrial fibrillation

  2. Our results demonstrate that ALK4 haploinsufficiency ameliorates cardiac fibrosis and dysfunction in a mouse pressure-overload model associated with inhibition of cardiac fibroblast activation and cardiomyocyte apoptosis through the suppression of Smad2/3 activity.

  3. ALK4 is an important profibrotic signaling molecule in the post-MI CF. Haplodeficiency of ALK4 significantly improved LV function and survival rate by attenuating CF in vivo, ameliorated

  4. Uterine Activin-Like Kinase 4 Regulates Trophoblast Development During Mouse Placentation

  5. These results indicate that an appropriate level of activin signaling may be required for GSIS in pancreatic beta cells, and that activin signaling involves modulation of KATP channel activity.

  6. Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.

  7. identified ACVRIB as a direct target of miR-145. The ectopic expression of miR-145 reduced the levels of both ACVRIB mRNA and protein and also interfered with activin-induced Smad2 phosphorylation.

  8. Results identify a molecular mechanism that explains the cell-type specific aspects of signaling by myostatin, ALK4, ALK5, and other TGF-beta family members.

  9. Inhibin alpha-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.

  10. Knockdown or pharmacological inhibition of the Nodal/Activin receptor Alk4/7 in cancer stem cells virtually abrogated their self-renewal capacity and in vivo tumorigenicity

  11. Our analysis of this Acvr1b knockout mouse line provides direct genetic evidence that Acvr1b signaling is required for both hair follicle development and cycling.

  12. analysis of expression and cellular compartmentalization of the activin receptors ActRIIA, ActRIIB and ActRIB, the inhibin co-receptor (betaglycan), and activin signaling proteins Smads 2, 3 and 4, and growth regulatory role during lactation

  13. Alk4 is expressed in the early development of thymocytes.

  14. activin receptor signaling is essential to optimize the performance of neuronal circuits in the mature brain under physiological conditions

  15. ALK5 is required in endothelial cells and vascular smooth muscle cells for yolk sac vasculogenesis; in the absence of ALK5, ALK4 mediates SMAD2 phosphorylation and consequently SMAalpha expression.

Human Activin A Receptor, Type IB (ACVR1B) interaction partners

  1. Overexpression of ALK4 suppressed glioma cell proliferation, migration and invasion through the inactivation of JAK/STAT3 signaling pathway.

  2. Results showed that ACVR1B expression is upregulated during latent infection with a miR-UL148D deletion virus. Data indicates miR-UL148D inhibits ACVR1B expression in latently infected cells to limit proinflammatory cytokine secretion.

  3. Our study provided experimental and clinical evidence for the involvement of activin A and ALK4 in the pathophysiology of atrial fibrosis and atrial fibrillation

  4. It was concluded that ALK4 inhibition increases myogenesis but also regulates the tight balance of protein synthesis and degradation.

  5. in a relatively large cohort of athletes from Europe and South America we have shown that the ACVR1B rs2854464 A allele is associated with sprint/power performance in Caucasians but not in Brazilian athletes.

  6. ALK4 is an important profibrotic signaling molecule in the post-MI CF. Haplodeficiency of ALK4 significantly improved LV function and survival rate by attenuating CF in vivo, ameliorated

  7. ALK4 is expressed in male germ cells and Sertoli cells.

  8. This study demonstrated positive regulation of monocyte/macrophage differentiation by lnc-MC and uncovered an elaborate regulation mechanism composed of PU.1, lnc-MC, miR-199a-5p, and ACVR1B.

  9. Data suggest that activin A up-regulates SNAIL expression via ALK4/ACVR1B-induced SMAD signaling in trophoblast cells; elevated SNAIL contributes to up-regulation of MMP2 expression which plays key role in promoting trophoblast cell invasion.

  10. ACVR1B functions as a positive regulator of monocyte/macrophage differentiation. ACVR1B knockdown promoted THP-1 proliferation by increasing Rb phosphorylation. Down-regulation reduced p-Smad2/3 and C/EBPalpha, inhibiting monocyte/macrophage differentiation.

  11. The deletion of the ACVR1B gene may mediate an aggressive cancer phenotype in pancreatic cancer.

  12. Findings define a regulatory role of miR-98 in tumor angiogenesis and invasion through repressed ALK4 and MMP11 expression.

  13. ActRIBCA signaling can promote cell migration in prostate cancer cells via a network of signaling molecules that work together to trigger the process of EMT, and thereby aid in the aggressiveness and progression of prostate cancers.

  14. Act A protein levels were significantly higher in NTM tissues compared to GTM tissues.

  15. Inhibin alpha-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.

  16. Activin A-ACVRIB/ALK4-Smad-dependent collagen production was augmented in SSc fibroblasts, suggesting the involvement of this signaling mechanism in systemic sclerosis.

  17. We applied a two-stage fine mapping approach, and are the first to identify and partially replicate genetic variants in the ACVR1B gene that account for genetic variation in human muscle strength.

  18. activin A signal is transduced through the activin A type 1 receptor, ALK4, and transactivates several TGF-beta target genes in a SMAD-independent manner.

  19. distribution in gestational tissues across human pregnancy and during labour

  20. data indicate that truncated Alk4 isoforms interfere with activin signaling pathways and thereby may contribute to uncontrolled cell growth

Activin A Receptor Type IB (ACVR1B) Antigen Profile

Protein Summary

This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with ACVR1B

  • activin A receptor type 1B (ACVR1B) antibody
  • activin A receptor type 1B (acvr1b) antibody
  • Activin receptor type-1B (acv1b) antibody
  • activin A receptor, type IB (ACVR1B) antibody
  • activin A receptor, type 1B (Acvr1b) antibody
  • activin A receptor type 1B (Acvr1b) antibody
  • activin A receptor type 1Ba (acvr1ba) antibody
  • 6820432J04 antibody
  • ActR-IB antibody
  • ACTRIB antibody
  • ACVR1B antibody
  • ACVRLK4 antibody
  • alk-4 antibody
  • ALK4 antibody
  • axis antibody
  • DKFZp469A1614 antibody
  • Skr2 antibody
  • taram-a antibody
  • tarama antibody
  • wu:fb75f01 antibody
  • xalk4 antibody

Protein level used designations for ACVR1B

activin A receptor, type IB , activin A receptor, type 1B , activin type IB receptor , activin receptor type-1B-like , Activin receptor type-1B , activin receptor IB , ALK-4 , activin receptor type IB , activin receptor type-1B , activin receptor-like kinase 4 , serine/threonine-protein kinase receptor R2 , activin A receptor, type II-like kinase 4 , ACTR-IB , Serine/threonine-protein kinase receptor R2

GENE ID SPECIES
100062619 Equus caballus
451911 Pan troglodytes
733849 Xenopus (Silurana) tropicalis
768878 Gallus gallus
100391614 Callithrix jacchus
100482103 Ailuropoda melanoleuca
100195539 Salmo salar
443254 Ovis aries
100173725 Pongo abelii
11479 Mus musculus
91 Homo sapiens
29381 Rattus norvegicus
30183 Danio rerio
486537 Canis lupus familiaris
100152462 Sus scrofa
539315 Bos taurus
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