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ACVR2A encodes activin A type II receptor. Additionally we are shipping Activin Receptor Type IIA Proteins (37) and Activin Receptor Type IIA Kits (15) and many more products for this protein.
Showing 10 out of 113 products:
TGF-beta (show TGFB1 Antibodies) receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.(
This locus harbors an evolutionary conserved gene-desert region with non-coding intergenic sequences likely involved in regulation of protein-coding flanking genes ZEB2 (show ZEB2 Antibodies) and ACVR2A. This region is intensively studied for mutations causing severe developmental/genetic disorders. Our analyses indicate a promising target region for interventions aimed to reduce risks of many major human diseases and mortality.
Data suggest ALK1 (show ACVRL1 Antibodies) and ACVR2A/ACVR2B (show ACVR2B Antibodies), acting as BMP9 (show GDF2 Antibodies) co-receptors, rearrange pro-domains of BMP9 (show GDF2 Antibodies)--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling.
Activin A (show INHBA Antibodies) inhibited signaling by BMP-6 (show BMP6 Antibodies) and BMP-9 (show GDF2 Antibodies) by competing for type 2 receptors ACVR2A and ACVR2B (show ACVR2B Antibodies).
Data suggest that an SNP in promoter region of ACVR2A (rs1424954, the pre-eclampsia susceptibility allele) down-regulates 1) expression of ACVR2A in trophoblasts and 2) signal transduction in response to excess activin-A (show INHBA Antibodies) (as seen in pre-eclampsia).
Adenomyotic tissues express high levels of myostatin (show MSTN Antibodies), follistatin (show FST Antibodies), and activin (show Actbeta Antibodies) type II receptors.
The gene ACVR2A was associated with the more severe early onset preeclampsia.
For ACVR2A SNPs (rs10497025, rs1128919, rs13430086), no statistically significant difference was found between preeclampsia and control groups in terms of genotype and allele frequencies.
ACVR2A was identified as a subnetwork component in functional association network analysis.
ACVR2A showed statistically significant differential dose-expression relationship.
This genome-wide association study identified variants in the upstream region of ACVR2A, which were associated with female fertility in Japanese Black cattle.
Roles in hindbrain and neural crest cell (NCC) patterning, in NCC derived pharyngeal arch cartilage and joint formation, and in tooth development.
Anti-ActRII blockade is an effective intervention against cancer cachexia providing benefit even in the presence of anti-cancer therapies.
Data, including data from studies using transgenic mice, suggest that osteoblasts deficient in Acvr2A exhibit un-characteristic features; osteoclasts deficient in Acvr2A or Acvr2B (show ACVR2B Antibodies) or both appear normal. Acvr2A-deficient mice exhibit significantly increased femoral trabecular bone volume at 6 weeks of age; Acvr2B (show ACVR2B Antibodies)-deficient mice exhibit no significant change in any bone parameter.
miR (show MLXIP Antibodies)-125b regulated the activin (show Actbeta Antibodies)/Smad2 (show SMAD2 Antibodies) signaling in neonatal mouse ovary by directly targeting the 3'-untranslated region of activin receptor type 2a
Our study shows that a miR (show MLXIP Antibodies)-590/Acvr2a/Rad51b (show Rad51B Antibodies) signaling axis ensures the stabilization of mESCs by balancing DNA damage repair and rapid proliferation during self-renewal.
Bmpr2 (show BMPR2 Antibodies) and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division.
Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1 (show HAND1 Antibodies), Th2, and Treg.
stimulates expression of APRIL via the Smad3 (show SMAD3 Antibodies) and ERK (show EPHB2 Antibodies)/CREB (show CREB1 Antibodies) pathways in macrophages
Results demonstrated that BMPRII (show BMPR2 Antibodies) and ActRII are the functional type II TGF-beta (show TGFB1 Antibodies) receptors in BMP-9 (show GDF2 Antibodies)-induced osteogenic differentiation of C3H10T1/2 cells.
The coordinated activity of ActRIIA and BMPRII (show BMPR2 Antibodies) receptor subunits selectively mediates the chemotactic response to BMP7 (show BMP7 Antibodies).
Activin (show Actbeta Antibodies) type IIB(ActRIIB (show ACVR2B Antibodies)) and its subfamily receptor, Activin (show Actbeta Antibodies) type IIA (ActRIIA), cooperatively mediate the Gdf11 (show GDF11 Antibodies) signal in patterning the axial vertebrae
This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
activin receptor IIA
, activin receptor type-2A
, activin A receptor, type IIA
, activin receptor type IIA
, type II activin receptor
, activin A receptor, type II
, activin receptor, type IIA
, activin receptor type II
, activin type 2 receptor
, activin receptor IIa