anti-Activin Receptor Type I (ACRV1) Antibodies

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins.

list all antibodies Gene Name GeneID UniProt
Anti-Human ACRV1 ACRV1 90 Q04771
Anti-Rat ACRV1 ACRV1 79558 P80201
Anti-Mouse ACRV1 ACRV1 11477 P37172
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Top anti-Activin Receptor Type I Antibodies at antibodies-online.com

Showing 10 out of 175 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  ACVR1  Sample Type:  Human Fetal Heart  Antibody Dilution:  1.0ug/ml Host:  Rabbit  Target Name:  ACVR1  Sample Type:  Human Fetal Lung  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-ACVR1 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate Human Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody (Center) (ABIN657777). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ACVR1 gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-ACVR1 Pab (ABIN392240) is used in Western blot to detect ACVR1 in HeLa cell lysate (Lane 1) and mouse liver tissue lysate (Lane 2). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN238620 (0.3µg/ml) staining of Human Umbilical Cord lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Goat Un-conjugated CyTOF, FACS, IHC, WB Detection of Activin RIA/ALK-2 in PC-3 Human Cell Line by Flow Cytometry. Activin RIA/ALK-2 in Human Astrocytoma. 100 μg Log in to see 8 to 9 Days
$433.55
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Western blot analysis of anti-ACVR1 Pab in mouse brain tissue lysate.ACVR1(arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-ACVR1 Pab in mouse brain tissue lysate. ACVR1(arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Mouse Rabbit Un-conjugated IHC, IHC (fro), WB Immunohistochemistry: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33500] - NCIN87 xenograft Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33500] - H1299 lysates. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details

Top referenced anti-Activin Receptor Type I Antibodies

  1. Human Polyclonal ACRV1 Primary Antibody for CyTOF, FACS - ABIN4899715 : Fujimoto, Ohte, Shin, Yoneyama, Osawa, Miyamoto, Tsukamoto, Mizuta, Kokabu, Machiya, Okuda, Suda, Katagiri: Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2. in Biochemical and biophysical research communications 2014 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal ACRV1 Primary Antibody for IHC (p), WB - ABIN392240 : ten Dijke, Ichijo, Franzén, Schulz, Saras, Toyoshima, Heldin, Miyazono: Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. in Oncogene 1993 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal ACRV1 Primary Antibody for IHC (p), IHC - ABIN256737 : Shore, Xu, Feldman, Fenstermacher, Cho, Choi, Connor, Delai, Glaser, LeMerrer, Morhart, Rogers, Smith, Triffitt, Urtizberea, Zasloff, Brown, Kaplan: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. in Nature genetics 2006 (PubMed)

More Antibodies against Activin Receptor Type I Interaction Partners

Human Activin Receptor Type I (ACRV1) interaction partners

  1. The role of an ALK2 mutation (R258S) in IRIDA (show TMPRSS6 Antibodies) development in a patient also bearing compound heterozygous mutations in TMPRSS6 (show TMPRSS6 Antibodies) was demonstrated by reconstructing in vitro the proband's genotype, expressing mutants TMPRSS6 (show TMPRSS6 Antibodies) and ACVR1 in the presence of hemojuvelin (show HFE2 Antibodies) and assessing hepcidin (show HAMP Antibodies) activation. ALK2(R258S) maintained high hepcidin (show HAMP Antibodies) expression in the presence of MT2 (show MT2 Antibodies)(I212T).

  2. activation of AMPK (show PRKAA1 Antibodies) upregulated Smad6 (show SMAD6 Antibodies) and Smurf1 (show SMURF1 Antibodies) and thereby enhanced their interactions, resulting in its proteosome-dependent degradation of ALK2.

  3. the Fibrodysplasia Ossificans Progressiva mutation ACVR1(R206H) is more sensitive to a number of natural ligands.

  4. both bone morphogenetic protein 2 (BMP2 (show BMP2 Antibodies)) and BMP6 (show BMP6 Antibodies) are proangiogenic in vitro and ex vivo and that the BMP type I receptors, activin receptor-like kinase 3 (ALK3 (show BMPR1A Antibodies)) and ALK2, play crucial and distinct roles in this process.

  5. Fibrodysplasia ossificans progressiva (FOP) syndrome is caused by mutation of the gene ACVR1. Developed is a simplified one-step procedure by simultaneously introducing reprogramming and gene-editing components into human fibroblasts derived from patient with FOP. The one-step-mediated ALK2 gene-corrected induced pluripotent stem cells restored global gene expression pattern.

  6. The ACVR1 R206H mutation may not directly increase the formation of mature chondrogenic or osteogenic cells.

  7. Authors demonstrated that the BMP type I receptor ALK-2 (encoded by the ACVR1 gene) has crucial roles in apoptosis induction of patient-derived glioma-initiating cells (GICs), TGS (show LIN9 Antibodies)-01 and TGS (show LIN9 Antibodies)-04.

  8. Data suggest BMP9/GDF2 (show GDF2 Antibodies) and BMP10 (show BMP10 Antibodies) synergize with TNFA (show TNF Antibodies) to increase monocyte recruitment to vascular endothelial cells; process appears to be mediated mainly via ALK2/ACVR1 (which exhibits protein kinase (show CDK7 Antibodies) activity). These studies used in vitro flow monocyte adhesion assay. (BMP9 (show GDF2 Antibodies) = growth differentiation factor 2 (show GDF2 Antibodies); BMP10 (show BMP10 Antibodies) = bone morphogenetic protein 10 (show BMP10 Antibodies); TNFA (show TNF Antibodies) = tumor necrosis factor alpha (show TNF Antibodies); ALK2/ACVR1 = activin A receptor type 1)

  9. The effects of ACVR1/ALK2 mutations causing fibrodysplasia ossificans progressiva are extended to the central nervous system. Brainstem hamartomatous lesions and dysmorphisms, variably associated with dentate nucleus and basal ganglia signal abnormalities and/or calcifications, may represent useful disease hallmarks.

  10. Low ALK2 expression is associated with invasiveness of breast cancer.

Mouse (Murine) Activin Receptor Type I (ACRV1) interaction partners

  1. NODAL/Activin (show Actbeta Antibodies) signaling induces dramatic chromatin landscape changes, and a dynamic transcriptional network regulated by SMAD2 (show SMAD2 Antibodies), acting via multiple mechanisms.

  2. Acute tacrolimus treatment transiently increases hepcidin (show HAMP Antibodies) in wild-type mice. FKBP12 (show FKBP1A Antibodies) preferentially targets the BMP receptor (show BMPR1A Antibodies) ALK2. ALK2 mutants defective in binding FKBP12 (show FKBP1A Antibodies) increase hepcidin (show HAMP Antibodies) expression in a ligand-independent manner, through BMP-SMAD (show SMAD1 Antibodies) signaling.

  3. The authors demonstrated that ubiquitin-specific protease (USP) 4 (show USP4 Antibodies) strongly induces activin (show Actbeta Antibodies)/BMP signaling by removing the inhibitory monoubiquitination from SMAD4 (show SMAD4 Antibodies).

  4. Enhanced SMAD (show SMAD1 Antibodies)-dependent BMP signaling through constitutively active ACVR1 in palatal epithelium causes submucous cleft palate in mice, via medial-edge-epithelium persistence presumably due to the up regulation of DeltaNp63 andresultingreductionofcaspase-3 activation. 2.

  5. BMP signaling mediated by coordination of ALK2/ACVR1, ALK3/BMPR1A (show BMPR1A Antibodies), and BMPR2 (show BMPR2 Antibodies) is an essential proangiogenic cue for retinal vessels.

  6. This study showed that Gja1 (show GJA1 Antibodies) may act downstream of cAMP-PKA signal to mediate the effects of Acvr1 on the differentiation of uterine stromal cells through targeting Hand2 (show HAND2 Antibodies).

  7. Results showed activin (show Actbeta Antibodies)-C and follistatin (show FST Antibodies) are differentially expressed during prostate development and suggested that the antagonistic property of follistatin (show FST Antibodies) is secondary to the action of activin (show Actbeta Antibodies)-C. Study provides evidence to support a role of activin (show Actbeta Antibodies)-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development.

  8. BMPR1B plays distinct roles from BMPR1A and ACVR1 in maintaining bone mass and transducing BMP signaling

  9. Suggest that BMP signaling upregulates the calcineurin/nuclear factor of activated T cell (show NFATC3 Antibodies) pathway via BMP type I receptor ALK2, contributing to cardiac hypertrophy and fibrosis.

  10. results suggest that ACVR1(R206H) causes FOP (show CHTOP Antibodies) by gaining responsiveness to the normally antagonistic ligand activin A (show INHBA Antibodies), demonstrating that this ligand is necessary and sufficient for driving HO in a genetically accurate model of FOP (show CHTOP Antibodies)

Horse (Equine) Activin Receptor Type I (ACRV1) interaction partners

  1. Data suggest that ACVR1 mRNA and protein are present in granulosa cells of ovarian follicles at mid-estrous and pre-ovulatory stages; ACVR1 mRNA and protein are also present in exosomes isolated from mid-estrous and preovulatory follicles.

Activin Receptor Type I (ACRV1) Antigen Profile

Protein Summary

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Gene names and symbols associated with ACRV1

  • activin A receptor type 1 (ACVR1) antibody
  • activin A receptor type 1 (Acvr1) antibody
  • activin A receptor, type 1 (Acvr1) antibody
  • activin A receptor type 1 S homeolog (acvr1.S) antibody
  • ActR-I antibody
  • ActR-IA antibody
  • actri antibody
  • ActRIA antibody
  • Acvr antibody
  • acvr1 antibody
  • acvr1-a antibody
  • acvr1-b antibody
  • acvr1a antibody
  • acvrlk2 antibody
  • alk-2 antibody
  • alk2 antibody
  • alk8 antibody
  • D330013D15Rik antibody
  • fop antibody
  • sax antibody
  • skr1 antibody
  • Tsk7L antibody
  • tsri antibody
  • xALK-2 antibody

Protein level used designations for ACRV1

TGF-B superfamily receptor type I , activin A receptor, type II-like kinase 2 , activin receptor type I , activin receptor type-1 , activin receptor-like kinase 2 , hydroxyalkyl-protein kinase , serine/threonine-protein kinase receptor R1 , ACTR-I , SKR1 , TSR-I , activin A receptor, type 1 , activin type I receptor , type I TGF B receptor , activin A receptor, type I , activin receptor type IA , TSK-7L , activin A receptor type 1 S homeolog , activin A receptor type I S homeolog , activin receptor like kinase-2

GENE ID SPECIES
90 Homo sapiens
79558 Rattus norvegicus
338068 Bos taurus
395246 Gallus gallus
443161 Ovis aries
11477 Mus musculus
478757 Canis lupus familiaris
100724428 Cavia porcellus
399083 Xenopus laevis
100050899 Equus caballus
697935 Macaca mulatta
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