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CTDSP1 encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. Additionally we are shipping CTDSP1 Proteins (7) and CTDSP1 Kits (4) and many more products for this protein.
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Dog (Canine) Polyclonal CTDSP1 Primary Antibody for ELISA - ABIN547899
Zhang, Kim, Genoud, Gao, Kelly, Pfaff, Gill, Dixon, Noel: Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. in Molecular cell 2006
Our results provide a novel mechanistic insight into the activation of Myc (show MYC Antibodies) by 27-HC via transcriptional repression of PP2A (show PPP2R4 Antibodies), SCP1 (show SYCP1 Antibodies) and FBW7 (show FBXW7 Antibodies) to increase Myc (show MYC Antibodies) protein stability in breast cancer cells.
SCP1 (show SYCP1 Antibodies) is the phosphatase that counterregulates the MAPK (show MAPK1 Antibodies)-mediated phosphorylation of Ser (show SIGLEC1 Antibodies)(68)-Twist1 (show TWIST1 Antibodies).
SCP1 (show SYCP1 Antibodies) regulates c-Myc (show MYC Antibodies) stability and functions through dephosphorylating c-Myc (show MYC Antibodies) Serine-62.
hSCP1 (show SCPEP1 Antibodies) may be an beta-O-linked N-acetylglucosamine modified protein in vivo.
CTDSP1 activity stabilizes REST in stem cells and ERK (show EPHB2 Antibodies)-dependent phosphorylation combined with Pin1 (show PIN1 Antibodies) activity promotes REST degradation in neural progenitors.
SCP1 (show SYCP1 Antibodies) phosphatase substrate specificity: CdcA3 (show CDCA3 Antibodies) could be an enzymatic substrate for SCP1 (show SYCP1 Antibodies).
SCP1 (show SYCP1 Antibodies) may play a role in the regulation of gene expression, possibly by controlling the transition from initiation/capping to processive transcript elongation
results show that REST/NRSF (show REST Antibodies) recruits SCPs to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells
SCP1 (show SYCP1 Antibodies) acts as a phosphatase for regulatory phosphorylations in the linker region of Smad1 (show GARS Antibodies) and Smad2 (show SMAD2 Antibodies).
Consistently, the authors observed increased AKT (show AKT1 Antibodies) phosphorylation and angiogenesis followed by enhanced tumorigenesis in Ctdsp1 (which encodes SCP1 (show CRISP1 Antibodies)) gene - knockout mice. Importantly, they discovered that the membrane localization of SCP1 (show CRISP1 Antibodies) is crucial for impeding angiogenesis and tumor growth, and this localization depends on palmitoylation of a conserved cysteine motif within its NH2 terminus.
Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas PKCalpha (show PKCa Antibodies)-phosphorylated BG21 inhibited its activity, suggesting a potential role of BG21 as a molecular switch ("quick-brake mechanism") on SCP1/GIP.
Findings suggest that SCP1 (show CRISP1 Antibodies) may inhibit the osteoblastic differentiation induced by the BMP-Smad (show SMAD1 Antibodies) axis via Runx2 (show RUNX2 Antibodies) by suppressing downstream effector(s).
This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
, NLI-interacting factor 3
, nuclear LIM interactor-interacting factor 3
, small C-terminal domain phosphatase 1
, golli-interacting protein
, small CTD phosphatase 1