CTDSP1 antibody (N-Term)

Catalog No. ABIN7184440

Product Details anti-CTDSP1 Antibody

Target: CTDSP1 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 (CTDSP1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTDSP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from N-terminal of Human CTDSP1.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CTDSP1

Target: CTDSP1 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 (CTDSP1))

Alternative Name: CTDSP1 (CTDSP1 Products)

Synonyms: CTDSP1 antibody, NIF3 antibody, NLI-IF antibody, NLIIF antibody, SCP1 antibody, fj83f12 antibody, im:7141428 antibody, wu:fj83f12 antibody, zgc:113169 antibody, GIP antibody, Nif3 antibody, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 antibody, CTD small phosphatase 1 antibody, carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 antibody, CTDSP1 antibody, Ctdsp1 antibody, ctdsp1 antibody, HCAG_04820 antibody, CTRG_06220 antibody

Background:

Background: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

Marquet S., Mamm. Genome 11:755-762(2000).
Yeo M., J. Biol. Chem. 278:26078-26085(2003).
Hillier L.W., Nature 434:724-731(2005)

Aliases: Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 1 antibody, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 antibody, CTD (carboxy terminal domain RNA polymerase II polypeptide A) small phosphatase 1 antibody, CTD small phosphatase 1 antibody, CTDS1_HUMAN antibody, CTDSP1 antibody, NIF3 antibody, NLI IF antibody, NLI interacting factor 3 antibody, NLI-IF antibody, NLI-interacting factor 3 antibody, NLIIF antibody, Nuclear LIM interactor interacting factor 3 antibody, Nuclear LIM interactor-interacting factor 3 antibody, SCP1 antibody, Small C-terminal domain phosphatase 1 antibody, Small CTD phosphatase 1 antibody

UniProt: Q9GZU7