This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This CTDSP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 16-50 amino acids from the N-terminal region of human CTDSP1.
CTDSP1 antibody, NIF3 antibody, NLI-IF antibody, NLIIF antibody, SCP1 antibody, fj83f12 antibody, im:7141428 antibody, wu:fj83f12 antibody, zgc:113169 antibody, GIP antibody, Nif3 antibody, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 antibody, CTD small phosphatase 1 antibody, carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 antibody, CTDSP1 antibody, Ctdsp1 antibody, ctdsp1 antibody, HCAG_04820 antibody, CTRG_06220 antibody
Background
Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.