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Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility.
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Human Polyclonal CDYL Primary Antibody for ELISA, WB - ABIN268636
Lahn, Tang, Zhou, Barndt, Parvinen, Allis, Page: Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. in Proceedings of the National Academy of Sciences of the United States of America 2002
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Human Monoclonal CDYL Primary Antibody for IF, ELISA - ABIN522877
Bantscheff, Hopf, Savitski, Dittmann, Grandi, Michon, Schlegl, Abraham, Becher, Bergamini, Boesche, Delling, Dümpelfeld, Eberhard, Huthmacher, Mathieson, Poeckel, Reader, Strunk, Sweetman, Kruse et al.: Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. ... in Nature biotechnology 2011
Cow (Bovine) Polyclonal CDYL Primary Antibody for IF, WB - ABIN2783639
Nousiainen, Silljé, Sauer, Nigg, Körner: Phosphoproteome analysis of the human mitotic spindle. in Proceedings of the National Academy of Sciences of the United States of America 2006
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These results demonstrate that CDYL is a regulator of neuronal migration and shed light on the pathogenesis of seizure-related neurodevelopmental disorders.
CDYL negatively regulates histone crotonylation by acting as a crotonyl-CoA hydratase to convert crotonyl-CoA to beta-hydroxybutyryl-CoA and suggest role in spermatogenesis.
A combination of H3K9me2 and H3K27me3 recruits Cdyl to the inactivated X chromosome, and this, in turn, may facilitate propagation of the H3K9me2 mark by anchoring G9a (show EHMT2 Antibodies).
The results of this study provided some insight into the molecular function of the Cdyl gene, showing that it inhibited the neuronal differentiation of iPS (show SLC27A4 Antibodies) cells.
Cdyl may participate in the global chromatin remodelling that occurs in spermatogenesis.
CDYL plays an important role in the maintenance of repressive histone marks during replication, providing a mechanism for understanding of the epigenetic inheritance and memory.
The epigenetic regulators CDYL and EZH2 (show EZH2 Antibodies) to dendrite morphogenesis and might shed new light on our understanding of the regulation of the neurodevelopment.
These findings suggest that h-CDYLb and G9a (show EHMT2 Antibodies) are cooperatively involved in hepatocellular carcinomas
CDYL functions as a molecular bridge between PRC2 and the repressive chromatin mark H3K27me3, forming a positive feedback loop to facilitate the establishment and propagation of H3K27me3 modifications along the chromatin
Chromodomain on Y-like (CDYL) is identified as a REST corepressor that physically bridges REST and the histone methylase G9a (show EHMT2 Antibodies) to repress transcription.
Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene.
chromodomain protein, Y chromosome-like
, chromodomain Y-like protein
, CDY-like, autosomal
, testis-specific chromodomain Y-like protein
, chromodomain Y-like protein-like
, chromodomain protein Y-like variant 2
, chromodomain protein Y-like variant 3
, chromodomain protein Y-like variant 4