anti-Endoglin (ENG) Antibodies

ENG encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. Additionally we are shipping Endoglin Kits (73) and Endoglin Proteins (53) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ENG 2022 P17813
ENG 13805 Q63961
ENG 497010  
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Top anti-Endoglin Antibodies at antibodies-online.com

Showing 10 out of 763 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of CD105 using anti- CD105 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat lung tissue lysates,   Lane 2: mouse lung tissue lysates,   Lane 3: HELA whole Cell lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti- CD105 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for CD105 at approximately 95KD. The expected band size for CD105 is at 81KD. 100 μg Log in to see 4 to 6 Days
$240.00
Details
Mouse Rabbit Un-conjugated ELISA, IHC (p), WB Western blot analysis of CD105 using anti-CD105 antibody . Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.  Lane 1: mouse lung tissue lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CD105 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 ug/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for CD105 at approximately 95-105KD. The expected band size for CD105 is at 71KD. IHC analysis of CD105 using anti-CD105 antibody .CD105 was detected in paraffin-embedded section of mouse kidney tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1ug/ml rabbit anti-CD105 Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-CD105 antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue Anti-CD105 antibody, Western blotting Lane 1: Recombinant Human CD105 Protein 10ng Lane 2: Recombinant Human CD105 Protein 5ng Lane 3: Recombinant Human CD105 Protein 2.5ng 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Goat Un-conjugated CyTOF, FACS, ICC, IHC, WB Endoglin/CD105 in U937 Human Cell Line. Endoglin/CD105 was detected in immersion fixed U937 human histiocytic lymphoma cell line using Goat Anti-Human Endoglin/CD105 Antigen Affinity-purified Polyclonal Antibody. Endoglin/CD105 in Human Prostate. Endoglin/CD105 was detected in immersion fixed paraffin-embedded sections of human prostate using Goat Anti-Human Endoglin/CD105 Antigen Affinity-purified Polyclonal Antibody. 100 μg Log in to see 8 to 9 Days
$464.43
Details
Mouse Goat Un-conjugated CyTOF, FACS, ICC, IHC, SimWes, WB Endoglin/CD105 in Rat Mesenchymal Stem Cells. Endoglin/CD105 was detected in immersion fixed rat mesenchymal stem cells using Goat Anti-Mouse Endoglin/CD105 Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to cytoplasm. Endoglin/CD105 in Mouse Embryo. Endoglin/CD105 was detected in immersion fixed frozen sections of mouse embryo (E13-15) using Goat Anti-Mouse Endoglin/CD105 Antigen Affinity-purified Polyclonal Antibody. Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. 100 μg Log in to see 8 to 9 Days
$435.05
Details
Human Rabbit Un-conjugated FACS, IF (cc), IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat pancreas tissue labeled with Anti-CD105 Polyclonal Antibody, unconjugated(ABIN707561) at 1: 200 followed by incubation with conjugated secondary antibody and DAB staining L1 rat brain, L2 rat heart lysates probed (ABIN707561) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted and observed band size: 70kDa. 100 μL Log in to see 3 to 7 Days
$329.45
Details
Human Mouse PE FACS Detection of Endoglin/CD105 in U937 Human Cell Line by Flow Cytometry. U937 human histiocytic lymphoma cell line was stained with Mouse Anti-Human Endoglin/CD105 PE-conjugated Mono-clonal Antibody. 100 Tests Log in to see 8 to 9 Days
$309.62
Details
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-CD105 Polyclonal Antibody (ABIN670401), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human placenta tissue labeled with Anti-CD105 Polyclonal Antibody, Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$329.45
Details
Guinea Pig Rabbit Un-conjugated IHC, WB WB Suggested Anti-ENG Antibody Titration:  2.0ug/ml  Positive Control:  HepG2 cell lysate Human Lung 100 μL Log in to see 2 to 3 Days
$249.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of CD105 expression in Hela (A), A549 (B), NIH3T3 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details

Top referenced anti-Endoglin Antibodies

  1. Human Polyclonal ENG Primary Antibody for CyTOF, FACS - ABIN4899973 : Glavaski-Joksimovic, Virag, Mangatu, McGrogan, Wang, Bohn: Glial cell line-derived neurotrophic factor-secreting genetically modified human bone marrow-derived mesenchymal stem cells promote recovery in a rat model of Parkinson's disease. in Journal of neuroscience research 2010 (PubMed)
    Show all 13 Pubmed References

  2. Mouse (Murine) Polyclonal ENG Primary Antibody for CyTOF, FACS - ABIN4900042 : Dolinsek, Markelc, Sersa, Coer, Stimac, Lavrencak, Brozic, Kranjc, Cemazar: Multiple delivery of siRNA against endoglin into murine mammary adenocarcinoma prevents angiogenesis and delays tumor growth. in PLoS ONE 2013 (PubMed)
    Show all 12 Pubmed References

  3. Human Monoclonal ENG Primary Antibody for FACS - ABIN4896997 : Choi, Shin, Lee, Park, Park, Nam, Kim, Woo, Yoon, Kang, Ra, Youn, Hong: Transplantation of CTLA4Ig gene-transduced adipose tissue-derived mesenchymal stem cells reduces inflammatory immune response and improves Th1/Th2 balance in experimental autoimmune thyroiditis. in The journal of gene medicine 2011 (PubMed)
    Show all 10 Pubmed References

  4. Human Polyclonal ENG Primary Antibody for IHC (p), WB - ABIN3042719 : Li, Zeng, Qi, Tang, Zhang, Wu, Liang, Shi, Liu, Zhang: Xenotransplantation of human adipose-derived stem cells in zebrafish embryos. in PLoS ONE 2015 (PubMed)
    Show all 9 Pubmed References

  5. Human Polyclonal ENG Primary Antibody for WB - ABIN5518816 : Gracza: [Molecular pharmacological investigation of medicinal plant substances. II. Inhibition of acetylcholinesterase by monoterpene derivatives in vitro]. in Zeitschrift fur Naturforschung. Section C, Biosciences 1985 (PubMed)
    Show all 8 Pubmed References

  6. Human Polyclonal ENG Primary Antibody for FACS, IF (cc) - ABIN707561 : Zhao, Yin, Guo, Wang, Wang, Chen: Placental expression of VEGF is increased in pregnancies with hydatidiform mole: possible association with developing very early onset preeclampsia. in Early human development 2013 (PubMed)
    Show all 8 Pubmed References

  7. Human Monoclonal ENG Primary Antibody for FACS - ABIN4896993 : Narcisi, Cleary, Brama, Hoogduijn, Tüysüz, ten Berge, van Osch: Long-term expansion, enhanced chondrogenic potential, and suppression of endochondral ossification of adult human MSCs via WNT signaling modulation. in Stem cell reports 2015 (PubMed)
    Show all 7 Pubmed References

  8. Mouse (Murine) Polyclonal ENG Primary Antibody for ELISA, IHC (p) - ABIN5518982 : Ren, Ren, Zhao, Wang, Zuo, Yu: Antitumor activity of endogenous mFlt4 displayed on a T4 phage nanoparticle surface. in Acta pharmacologica Sinica 2009 (PubMed)
    Show all 7 Pubmed References

  9. Human Polyclonal ENG Primary Antibody for FACS, ELISA - ABIN1003125 : Cheifetz, Bellón, Calés, Vera, Bernabeu, Massagué, Letarte: Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. in The Journal of biological chemistry 1992 (PubMed)
    Show all 6 Pubmed References

  10. Mouse (Murine) Monoclonal ENG Primary Antibody for IHC (f), FACS - ABIN1981859 : Dassler, Roohi, Lohrke, Ide, Remmele, Hütter, Pietsch, Pison, Schütz: Current limitations of molecular magnetic resonance imaging for tumors as evaluated with high-relaxivity CD105-specific iron oxide nanoparticles. in Investigative radiology 2012 (PubMed)
    Show all 5 Pubmed References

More Antibodies against Endoglin Interaction Partners

Human Endoglin (ENG) interaction partners

  1. The ratio of sFlt-1/sEGFR could be used as a novel candidate biochemical marker in monitoring the severity of preterm preeclampsia. sEndoglin and sEGFR may be involved in the pathogenesis of small for gestational age in preterm preelampsia.

  2. Increased cord blood soluble endoglin is associated with the development of severe or moderate bronchopulmonary dysplasia in preterm infants with maternal preeclampsia.

  3. ENG, ACVRL1, and SMAD4 mutations result in different phenotypes in hereditary hemorrhagic telangiectasia

  4. High expression of CD105 is associated with Oral Invasive Carcinomas.

  5. The role of CD34 in determining the premalignant nature of ral submucous fibrosis (OSF) could not be ascertained, since all endothelial cells were positive for CD34, whereas CD105 appeared to be more specific as it is associated with hypoxia-induced angiogenesis which is occurring in OSF due to hyalinization suggesting, CD105 to be more specific marker to determine neoangiogenesis in OSF

  6. Data show that the extracellular domain of endoglin promotes specific platelet adhesion.

  7. ENG mutation carriers were more likely than ACVRL1 mutation carriers to have pAVMs (P < 0.001) or multiple lesions (P = 0.03), and to undergo procedural intervention (P = 0.02). The HHT severity score was significantly higher in ENG than in ACVRL1 (P = 0.02).

  8. Increased CD105 expression is associated with disease progression in phyllodes tumors

  9. levels of the angiogenesis mediators endoglin, HB-EGF, BMP-9 and FGF-2 in patients with severe sepsis and septic shock; endoglin and HB-EGF could be involved in the host response of sepsis; additional studies are warrant to investigate their role as biomarker or therapeutic targets in sepsis

  10. A heterozygous genetic variant, c.704dupC; p.Val236Glyfs*98, was identified in the ENG gene. The variant c.704dupC was not previously described in the HHT Mutations Database

  11. Endoglin levels are changed after stroke.

  12. we found significant correlation with CD105 and survival rate of the patient. Similar correlation was found between histological grades and TNM staging in CD105. High expression was associated with low survival; whereas no significant correlation was found with expression of VEGF with survival, also with TNM staging and histological grading.

  13. CD105 expression was associated with more aggressive tumor behavior, more advanced disease, and worse prognosis in clear cell renal cell carcinoma

  14. Data indicate that in pancreatic cancer cells, the expression of ENG may be controlled by a pathway mediated by SMAD4. In addition, ENG was found to be related to the spheroid-forming ability of cells and to be involved in the invasive capacity of pancreatic cancer cells.

  15. CD105 is expressed on endothelial cells of rhabdomyosarcoma and represent a useful tool to quantify neovascularization in this tumor. If confirmed by further studies, these results will indicate that CD105 is a potential target for combined therapies in rhabdomyosarcoma.

  16. The increase in TGF-beta3 found in inflammatory wound healing (WF) highlights its negative effect on wound healing, while the increased levels of sEng in granulating WF affects the leukocyte adhesion/transmigration through the endothelium, reducing the inflammatory response and favoring the wound healing.

  17. Soluble endoglin level could serve as a determinant of walking abilities change after supervised treadmill training program in patients with peripheral artery disease.

  18. serum level elevated in pre-eclampsia, not significantly affected by HIV status

  19. high serum level at 26-31 weeks of gestational was a risk factor for a small-for-gestational-age infant at 35-41 weeks

  20. In primary hip OA, angiogenesis may be induced by a combined mechanism: hypoxia-related VEGF-dependent vasculogenesis and endothelial differentiation of the activated pluripotent cells, which are released from the hyperplastic synovial cells layer. An endothelial mesenchymal transition is assumed to be involved in the fibrotic process

Mouse (Murine) Endoglin (ENG) interaction partners

  1. Transplantation of mesenchymal stem cells, when combined with endothelial progenitor cells, accelerate muscle recovery in a mouse model of hind limb ischemia, through an endoglin-dependent mechanism.

  2. we cannot rule out a possibility that a long-term chronic exposure (9 months and more) to soluble endoglin alone or combined with other cardiovascular risk factors may contribute to alterations of heart function and structure in Sol-Eng+ mice, which is the topic in our lab in ongoing experiments

  3. Data show that concomitant activin receptor-like kinase 1 (Acvrl1) and endoglin (Eng) deficiency synergistically decreases pancreatic neuroendocrine tumor volume.

  4. Endoglin is necessary for the pro-angiogenic properties of the cardiosphere-derived cells secretome.

  5. systemic DPP4 inhibition restores the impaired mononuclear cell homing in Eng+/- animals post-myocardial infarction, and enhances cardiac repair, which might be explained by restoring the balance between the inflammatory and regenerative macrophages present in the heart

  6. results suggest that soluble endoglin modulates inflammatory-related diseases and open new perspectives leading to the development of novel and targeted approaches for the prevention and treatment of cardiovascular diseases

  7. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.

  8. Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling.

  9. Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes

  10. Endoglin has an important role in VSMC recruitment and blood vessel maturation during angiogenesis.

  11. the TGFbeta1 coreceptor Eng selectively regulates expression of multiple transient receptor potential channels in the setting of left or right ventricular pressure overload

  12. Endothelial cell-specific endoglin expression in islets of Langerhans is sensitive to VEGF and plays partial roles in driving islet vascular development, however such regulation appears to be distinct to mechanisms required to modulate islet viability and size.

  13. Study provides evidence that the expression of endoglin is required for the establishment of uterine receptivity and the decidualization process, which mediate embryo adhesion or the attachment reaction.

  14. The changes in CD90 and CD105 expression in the testis and ovary of mice are reported.

  15. the altered immune activity of endoglin deficient macrophages could help to explain the higher rate of infectious diseases seen in HHT1 patients.

  16. These results demonstrate a requirement for endoglin in descendants of Pax3-expressing vascular cell precursors.

  17. The similarities in Eng-/- and Mlc2a-/- embryos suggest that Eng-/- mice may suffer from a primary heart developmental defect and secondary defects in vessel patterning.

  18. results of our study provide evidence of endoglin as a valid target for cancer therapy and support further development of plasmid shRNA delivery, which have prolonged antitumor effect, especially in combined schedules

  19. ENG deficiency leads to EC hyperpermeability through constitutive activation of RhoA and destabilization of endothelial barrier function.

  20. endoglin is not localized with cell adhesion molecules involved in atherosclerosis, suggesting it might not participate in leukocyte accumulation in aorta of apoE-deficient mice during atherogenesis

Endoglin (ENG) Antigen Profile

Protein Summary

This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Endoglin (ENG) Antibodies

  • endoglin (ENG) antibody
  • endoglin (Eng) antibody
  • AI528660 antibody
  • AI662476 antibody
  • CD105 antibody
  • DKFZp469D0419 antibody
  • END antibody
  • ENG antibody
  • HHT1 antibody
  • MGC137842 antibody
  • ORW1 antibody
  • S-endoglin antibody

Protein level used designations for anti-Endoglin (ENG) Antibodies

endoglin (Osler-Rendu-Weber syndrome 1) , endoglin , endoglin-like , CD105 antigen , cell surface MJ7/18 antigen , transmembrane glycoprotein

GENE ID SPECIES
609166 Canis lupus familiaris
615844 Bos taurus
741046 Pan troglodytes
771557 Gallus gallus
100173392 Pongo abelii
100226246 Taeniopygia guttata
100357448 Oryctolagus cuniculus
100387791 Callithrix jacchus
397096 Sus scrofa
2022 Homo sapiens
13805 Mus musculus
497010 Rattus norvegicus
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