anti-NLR Family, CARD Domain Containing 5 (NLRC5) Antibodies

NLRC5 encodes a member of the caspase recruitment domain-containing NLR family.

list all antibodies Gene Name GeneID UniProt
NLRC5 84166 Q86WI3
NLRC5 434341 C3VPR6
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Top anti-NLRC5 Antibodies at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 0.05 mg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.1 mg 11 Days
$539.00
Details
Human Rabbit Un-conjugated ELISA, FM, WB Immunofluorescence of NOD4 Antibody Immunofluorescence Microscopy of NOD4 antibody. Tissue: HeLa cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: NOD4 antibody at 20 µg/mL for 1 h at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: NOD4 is cytoplasmic. Staining: NOD4 as red fluorescent signal. Immunocytochemistry of NOD4 Antibody Immunocytochemistry of NOD4 antibody. Tissue: HeLa cells. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: NOD4 antibody at 10 µg/mL for 1 h at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: NOD4 is cytoplasmic. Staining: NOD4 as precipitated blue signal with brown counterstain. 100 μg 1 to 2 Days
$405.90
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB 50 μg 12 to 14 Days
$670.26
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 6 to 8 Days
$511.50
Details
Human Rabbit Un-conjugated ICC, IF, ELISA, WB   100 μg 15 to 19 Days
$513.04
Details
Human Rabbit Un-conjugated ELISA, ICC, WB Western blot analysis of NLRC5 in EL4 cell lysate with NLRC5 polyclonal antibody  at 1 ug/mL. Immunocytochemical staining of HeLa cells with NLRC5 polyclonal antibody  at 10 ug/mL. 100 μg 11 to 12 Days
$460.00
Details
Human Rabbit Un-conjugated ICC, ELISA, WB 0.1 mg 2 to 3 Days
$370.00
Details
Human Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$581.17
Details

More Antibodies against NLRC5 Interaction Partners

Pig (Porcine) NLR Family, CARD Domain Containing 5 (NLRC5) interaction partners

  1. The NLRC5 transcript in pigs is relatively conservative among mammals and may play a vital role in immune reaction, which provides a basis for further studies on the NLRC5 function in the pig immune system and the role in comparative immunity.

Human NLR Family, CARD Domain Containing 5 (NLRC5) interaction partners

  1. Study in human hepatic stellate cell line LX-2 revealed that NLRC5 may participate in the process of hepatic stellate cells activation and extracellular matrix synthesis through the NF-kappaB signaling pathway and may play a key role in the development and reversal of hepatic fibrosis.

  2. High NLRC5 expression is associated with clear cell renal cell carcinoma.

  3. frameshift mutations in DTX1 and NLRC5, two genes involved in immune regulation, were identified in a family with familial pityriasis rubra pilaris.

  4. This study evaluated the effect of Orientia tsutsugamushi on the internal immunological systems of HeLa and aortic endothelial cells.

  5. NLRC5 could potentially be a diagnostic index and represents a prognostic factor in IgA nephritis patients.

  6. the methylation profile combination of HKR1, ROD1, and NLRC5 could be a promising biomarker for aging in Hainan centenarians

  7. The expression of NLRC5 in the ectopic and eutopic endometrium of endometriosis groups was significantly higher than that in the endometrium of leiomyoma group.

  8. NLRC5 performed a crucial role in the process of cardiac fibrosis

  9. Genetic polymorphisms in NLRC5 may be used as prognostic markers of survival of colorectal cancer patients, as well as for survival in response to 5-FU treatment.

  10. knockdown of NLRC5 attenuates renal ischemia/reperfusion injury in vitro through the activation of PI3K/Akt signaling pathway.

  11. NLRC5 may act as a key mediator in renal fibroblast activation and fibrogenesis

  12. obtained 18 pair-wise interactions within and between the NLRC5 ad PD-L1 genes and 6 more when IFNGR variants were added

  13. Our study, for the first time, identified the possible involvement of a polymorphism within NLRC5 gene as a possible biomarker for periodontitis condition susceptibility among Italian individuals from genetic isolates.

  14. NLRC5 interacts with miR-34a.NLRC5 role in HPV16 persistence.

  15. These results demonstrate that NLRC5 promotes hepatocellular carcinoma progression via the AKT/VEGF-A signaling pathway

  16. NLRC5 not only positively correlates with the increase of beta-catenin but also coordinates the activation of downstream Wnt/beta-catenin signaling pathway, regulating cell proliferation, migration and invasion in hepatocellular carcinoma.

  17. silencing NLRC5 reduced extracellular matrix expression in keloid fibroblasts through inhibiting the TGF-beta1/Smad signaling pathway.

  18. CITA/NLRC5 and CIITA are transcriptional regulators that orchestrate the concerted expression of critical components in the MHC class I and class II pathways, respectively. [review]

  19. NLRC5 expression was significantly associated with the activation of CD8(+) cytotoxic T cells and patient survival in multiple cancer types. Thus, NLRC5 constitutes a novel prognostic biomarker and potential therapeutic target of cancers.

  20. NLRC5 regulates TGFB1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis.

Mouse (Murine) NLR Family, CARD Domain Containing 5 (NLRC5) interaction partners

  1. Compared with the normal mice, the expression level of Nlrc5 increased significantly in the fibrosis group but decreased significantly in the recovery group. Nlrc5 may play a key role in the development and reversal of hepatic fibrosis through the NF-kappaB signaling pathway.

  2. Study using NLRC5 deficient mice found that NLRC5 exacerbated renal injury by the development of postischemic renal inflammation and the induction of tubular epithelial cell apoptosis that was associated with, at least in part, the negative regulation of CEACAM1. This suggests that NLRC5 signaling in renal parenchymal cells plays the dominant role in mediating renal damage.

  3. Taken together, NLRC5 promotes inflammation and fibrosis during diabetic nephropathy progression partly through the effects on NF-kappaB and TGF-beta/Smad pathways.

  4. NLRC5 knockout mice fed with high fat showed accelerated fibrosis and inflammation response by promoting alpha-SMA, Collagen I, Collagen III, TLR4/MyD88, phosphorylated IKKalpha, IkappaBalpha and NF-kappaB expression.

  5. NLRC5 knockout in mice exhibited greater hepatic injury after hepatic ischemia/reperfusion (I/R) injury.

  6. The observed increases in viral titers in NLRC5-deficient mice correlated with impaired effector CD8(+) T cell responses. Although NLRC5-deficient mice were defective at clearing the virus, they did not show an increase in morbidity or mortality following influenza virus infection because of other compensatory immune mechanisms.

  7. NLRC5 regulates TGFB1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis.

  8. NLRC5 is differentially expressed in hepatic tissues and hepatic stellate cells during hepatic fibrosis and its reversal

  9. NLRC5 expression in T cells is required to protect them from NK-cell-mediated elimination upon inflammation.

  10. NLRC5 and CIITA thus emerge as paradigms for a novel class of transcriptional regulators dedicated for transactivating extremely few, phylogenetically related genes.

  11. Unusual structural features revealed by the solution NMR structure of the NLRC5 caspase recruitment domain.

  12. Data conclude that Nlrc5 is important in the regulation of MHC-I expression by reducing H3K27me3 on MHC-I promoter and joins CIITA as an NLR subfamily that controls MHC gene transcription.

  13. NLRC5 is required for both constitutive and inducible histocompatibility class I gene expression and host defense.

  14. NLRC5 ablation reduces MHC class I expression, and enhances IKK and IRF3 phosphorylation in response to TLR stimulation or viral infection.

  15. NLRC5-deficient mice showed a profound defect in the expression of MHC class I genes and a concomitant failure to activate L. monocytogenes-specific CD8(+) T cell responses, including activation, proliferation and cytotoxicity.

  16. NLRC5 overexpression promotes interleukin (IL)-1beta production via caspase-1 and is dispensable for cytokine induction in virus and bacterial infections under physiologic conditions.

  17. NLRC5 expression is critical for lipopolysaccharide-induced interleukin (IL)-10 production in RAW264.7 macrophages.

  18. Study identifies NLRC5 as a negative regulator that blocks two central components of the NF-kappaB and type I interferon signaling pathways and suggest an important role for NLRC5 in homeostatic control of innate immunity.

NLRC5 Antigen Profile

Protein Summary

This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways.

Gene names and symbols associated with NLRC5

  • NLR family CARD domain containing 5 (NLRC5) antibody
  • NLR family, CARD domain containing 5 (NLRC5) antibody
  • NLR family CARD domain containing 5 (nlrc5) antibody
  • NLR family, CARD domain containing 5 (Nlrc5) antibody
  • AI451557 antibody
  • AK220210 antibody
  • CLR16.1 antibody
  • NOD4 antibody
  • NOD27 antibody

Protein level used designations for NLRC5

NLR family, CARD domain containing 5 , protein NLRC5 , NOD-like receptor C5 , caterpiller protein 16.1 , nucleotide-binding oligomerization domain protein 4 , nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5 , nucleotide-binding oligomerization domains 27

GENE ID SPECIES
487268 Canis lupus familiaris
703437 Macaca mulatta
782441 Bos taurus
100021163 Monodelphis domestica
100052017 Equus caballus
100135667 Sus scrofa
100303710 Ictalurus punctatus
100476937 Ailuropoda melanoleuca
84166 Homo sapiens
434341 Mus musculus
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