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p53/TP53-regulated repressor of Akt/AKT1 signaling. Additionally we are shipping PHLDA3 Proteins (6) and PHLDA3 Kits (1) and many more products for this protein.
Showing 10 out of 45 products:
Human Monoclonal PHLDA3 Primary Antibody for WB - ABIN2452076
Kawase, Ohki, Shibata, Tsutsumi, Kamimura, Inazawa, Ohta, Ichikawa, Aburatani, Tashiro, Taya: PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. in Cell 2009
Show all 2 Pubmed References
Human Polyclonal PHLDA3 Primary Antibody for ELISA - ABIN547194
Frank, Mendelsohn, Ciccone, Svensson, Ohlsson, Tycko: A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. in Mammalian genome : official journal of the International Mammalian Genome Society 2000
although iPSCs and ESCs share lots of common features, we did not find that PHLDA3 is important to ES cell differentiation.
Low PHLDA3 expression in ESCC may be predictive of tumor recurrence suggesting that Akt activation may be a therapeutic target in ESCCs
Results indicate that tumor suppressor PHLDA3-mediated pathway is important in the development of pancreatic neuroendocrine tumors (PanNETs).
findings indicate somatic mutation of PHLDA3 is rare in common cancer types; PHLDA3 expression was lost in 22% of prostate cancers; these results indicate that PHLDA3 are altered in prostate cancers by loss of expression
Study identifies PHLDA3 as a p53 target gene that encodes a PH domain-only protein and finds that PHLDA3 competes with the PH domain of Akt for binding of membrane lipids, inhibiting Akt translocation to the cellular membrane and activation.
Phlda3 may cause p53 accumulation through a feedforward pathway, facilitating tubular injury and its urine excretion.
Data indicate that tumor suppressor PHLDA3-deficient mice develop islet hyperplasia.
Ipl and Tih1 are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs.
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor (By similarity).
pleckstrin homology-like domain, family A, member 3
, TDAG51/Ipl homolog 1
, pleckstrin homology-like domain family A member 3
, pleckstrin homology-like domain, family A, member 2
, TDAG/lpl homolog 1