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Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Additionally we are shipping Rap Guanine Nucleotide Exchange Factor (GEF) 6 Antibodies (36) and many more products for this protein.
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local accumulation of PDZGEF at the apical membrane during establishment of epithelial polarity is mediated by electrostatic interactions between positively charged side chains in the PDZ domain and negatively charged phosphatidic acid.
BAG3 (show BAG3 Proteins) overexpression increases cell adhesion in Cos7 cells, but not in PDZGEF2 gene knockdown cells indicating that PDZGEF2 is a critical partner for BAG3 (show BAG3 Proteins) in regulating cell adhesion
the second PDZ domain from human phosphatase hPTP1E (show PTPN13 Proteins) in complex with a C-terminal peptide from the guanine nucleotide exchange factor (show RASGRF1 Proteins) RA-GEF-2 has been determined
haplotypes underlying the SPEC2 (show CDC42SE2 Proteins)/PDZ-GEF2/acyl-CoA synthetase long-chain family member 6 (show ACSL6 Proteins) region are associated with schizophrenia
PDZ-GEF2 plays a critical role in the maturation of adherens junctions.
When males and females were analysed separately, SNP4 (rs31251) in PDZ-GEF2 is associated with schizophrenia in females in Han Chinese.
JAM-A (show F11R Proteins) dimerization facilitates formation of a complex with Afadin and PDZ-GEF2 that activates Rap1A (show RAP1A Proteins), which regulates beta1 integrin levels and cell migration.
Rapgef2 (show RAPGEF2 Proteins)-conditional knockout (cKO) mice and Rapgef6-KO mice exhibited hyperlocomotion phenotype and working-memory defect, both of which could be recognized as schizophrenia-like behavior.
Study show that double knockout of Rapgef6 in Rapgef2 (show RAPGEF2 Proteins)-cKO mice (Rapgef2 (show RAPGEF2 Proteins)/6-dKO) results in marked enlargement of the ectopic cortical mass. While Rapgef2 (show RAPGEF2 Proteins)-cKO affects late-born neurons only, Rapgef2 (show RAPGEF2 Proteins)/6-dKO affects both early-born and late-born neurons in the developing brain.
Rapgef6 deletion mice were impaired in hippocampal and amygdalar function and had reduced spine density and primary dendrite number in pyramidal neurons of the CA3 (show CA3 Proteins) hippocampal region.
Data indicate that the testes of RA-GEF-2(-)knockout male mice were significantly smaller than those of wild-type mice and were markedly atrophied as well as hypospermatogenic.
These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras (show MRAS Proteins) and Rap1 (show TERF2IP Proteins), mediated by RA-GEF-2, in adhesion signaling.
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.
Rap guanine nucleotide exchange factor (GEF) 6
, PDZ domain-containing guanine nucleotide exchange factor I
, rap guanine nucleotide exchange factor 6-like
, PDZ domain containing guanine nucleotide exchange factor (GEF) 2
, PDZ domain-containing guanine nucleotide exchange factor 2
, rap guanine nucleotide exchange factor 6
, PDZ domain containing guanine nucleotide exchange factor(GEF)1
, rap guanine nucleotide exchange factor 2